Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5161-5164

  Gerspacher, Marc ^a   Altmann, Eva ^a   Beerli, René ^a   Buhl, Thomas ^a   Endres, Ralf ^a   Gamse, Rainer ^a   Kameni Tcheudji, Jacques ^a   Kneissel, Michaela ^a   Krawinkler, Karl Heinz ^a   Missbach, Martin ^a   Schmidt, Alfred ^a   Seuwen, Klaus ^a   Weiler, Sven ^a   Widler, Leo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Benzimidazoles; Bone formation; Calcium sensing receptor (CaSR); CaSR antagonist; Osteoporosis; Parathyroid hormone (PTH)

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CALCIUM SENSING RECEPTOR;

ARTICLE; DRUG MECHANISM; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; MODELS, MOLECULAR; RECEPTORS, CALCIUM-SENSING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955656602     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.016     Document Type: Article

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