Tepoxalin inhibits inflammation and microvascular dysfunction induced by abdominal irradiation in rats

Alimentary Pharmacology and Therapeutics

Volumn 14, Issue 6, 2000, Pages 841-850

  Panes J ^a,e   Molla M ^b   Casadevall, M ^a   Salas, A ^a   Sans, M ^a   Conill, C ^b   Anderson, D C ^c   Rosello Catafau J ^b   Granger, D N ^d   Pique J M ^a  

^a Institut Clinic de Malalties Digestives i Metaboliques   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c PFIZER INC   (United States)

^d LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^e HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALBUMIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4; TEPOXALIN; ZILEUTON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL ADHESION; ELECTROPHORETIC MOBILITY; INFLAMMATION; MALE; MESENTERIC VEIN; NONHUMAN; PRIORITY JOURNAL; RADIOTHERAPY; RAT;

ABDOMEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL ADHESION; DIGESTIVE SYSTEM; INFLAMMATION; LEUKOCYTES; LEUKOTRIENE B4; MALE; PERMEABILITY; PYRAZOLES; RADIOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034078926     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.00771.x     Document Type: Article

References (32)

1. 1 Buell MG, Harding RK. Proinflammatory effects of local abdominal irradiation on rat gastrointestinal tract. Dig Dis Sci 1989; 34: 390-9.
2. 2 Narayan K, Cliff WJ. Morphology of irradiated microvasculature: a combined in vivo and electron-microscopic study. Am J Pathol 1982; 106: 47-62.
3. 3 Panès J, Anderson DC, Miyasaka M, Granger DN. Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats. Gastroenterology 1995; 108: 1761-9.
4. 4 Panès J, Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 1998; 114: 1066-90.
5. 5 Asako H, Kubes P, Wallace J, Gaginella T, Wolf RE, Granger DN. Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Am J Physiol 1992; 262: G903-8.
6. 6 Zimmerman BJ, Guillory DJ, Grisham MB, Gaginella TS, Granger DN. Role of leukotriene B4 in granuloeyte infiltration into the postischemic feline intestine. Gastroenterology 1990; 99: 1358-63.
7. 7 Hallahan DE, Virudachalam S. Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation. Proc Natl Acad Sci USA 1997; 94: 6432-7.
8. 8 Behrends U, Peter RU, Hintermeier-Knabe R, et al. Ionizing radiation induces human intercellular adhesion molecule-1 in vitro. J Invest Dermatol 1994; 103: 726-30.
9. 9 Baeuml H, Behrends U, Peter RU, et al. Ionizing radiation induces, via generation of reactive oxygen intermediates, intercellular adhesion molecule-1 (ICAM-1) gene transcription and NF kappa B-like binding activity in the ICAM-1 transcriptional regulatory region. Free Radic Res 1997; 27: 127-42.
10. 10 Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J-Immunol 1996; 157: 1630-7.
11. 11 House SD, Lipowsky H. Leukocyte-endothelium adhesion: microdynamics in mesentery of the cat. Microvasc Res 1987; 34: 363-79.
12. 12 Panes J, Granger DN. Neutrophils generate oxygen free radicals in mesenteric microcirculation after abdominal irradiation. Gastroenterology 1996; 111: 981-9.
13. 13 Tamatani T, Miyasaka M. Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int Immunol 1990; 2: 165-71.
14. 14 Ma L, Raycroft L, Asa D, Anderson DC, Geng JG. A sialoglycoprotein from human leukocytes functions as a ligand for P-selectin. J Biol Chem 1994; 269: 27 739-46.
15. 15 Panés J, Perry MA, Anderson DC, et al. Regional differences in constitutive and induced ICAM-1 expression in vivo. Am J Physiol 1995; 269: H1995-64.
16. 16 Marui N, Offermann MK, Swerlick R, et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993; 92: 1866-74.
17. 17 Carty TJ, Sweeney FJ, Griffiths RJ. et al. Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. Inflamm Res 1997; 46: 168-79.
18. 18 Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78: 206-9.
19. 19 Kirchner T, Aparicio B, Argentieri DC, Lau CY, Ritchie DM. Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygcnase, on events associated with NSAID-induced gastrointestinal inflammation. Prostaglandins Leukotr Essent Fatty Acids 1997; 56: 417-23.
20. 20 Kazmi SM, Plante RK, Visconti V, Taylor GR, Zhou L, Lau CY. Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase. J Cell Biochem 1995; 57: 299-310.
21. 21 Willburger RE, Wittenberg RH, Schmidt K, Kleemeyer KS, Peskar BA. Antiinflammatory effect of tepoxalin: blood and synovial tissue studied in patients with knee arthrosis. Acta Orthop Scand 1998; 69: 295-300.
22. 22 Carter GW, Young PR, Albert DH. et al. 5-lipoxygenase inhibitory activity of Zileuton. J Pharmacol Exp Ther 1991; 256: 929-37.
23. 23 Dunn MM, Drab EA, Rubin DB. Effects of irradiation on endothelial cell-polymorphonuclear leukocyte interactions. J Appl Physiol 1986; 60: 1932-7.
24. 24 Hallahan D, Kuchibhotla J, Wyble C. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res 1996; 56: 5150-5.
25. 25 Zhou L, Pope BL, Chourmouzis E, Fung Leung WP, Lau CY. Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression. Eur J Immunol 1996; 26: 120-9.
26. 4-induced hyperadhesiveness of endothelial cells for neutrophils: relation to CD54. Clin Exp Immunol 1992; 90: 300-4.
27. 27 Zimmerman BJ, Holt JW, Paulson JC, et al. Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. Am J Physiol 1994; 266: H847-53.
28. 28 MacNaughton WK, Prud'homme-Lalonde L. Exposure to ionizing radiation alters vasoreactivity in rat jejunum ex vivo. Can J Physiol Pharmacol 1995; 73: 699-705.
29. 29 Cole AT, Slater K, Sokal M, Hawkey CJ. In vivo rectal inflammatory mediator changes with radiotherapy to the pelvis. Gut 1993; 34: 1210-4.
30. 30 Gross NJ, Holloway NO, Narine KR. Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis. Radiat Res 1991; 127: 317-24.
31. 31 Barendsen GW. Dose fractionation, dose rate, and isoeffect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 1982; 8: 1981-97.
32. 32 Langberg CW, Sauer T, Reitan JB, Hauer JM. Tolerance of rat small intestine to localized single dose and fractionated irradiation. Acta Oncol 1992; 31: 781-7.