Islet xenotransplantation: The pig-to-non-human primate model

Xenotransplantation

Volumn 15, Issue 2, 2008, Pages 104-106

  Bottino, Rita ^a   Cooper, David K C ^b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CD40 LIGAND MONOCLONAL ANTIBODY; COBROTOXIN; DEXTRAN SULFATE; GLUCOSE; HEPARIN; IMMUNOSUPPRESSIVE AGENT; INSULIN;

CONFERENCE PAPER; DIABETES MELLITUS; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INSTANT BLOOD MEDIATED INFLAMMATORY REACTION; NONHUMAN; OUTCOME ASSESSMENT; PANCREAS ISLET TRANSPLANTATION; PRIMATE; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

ANIMALS; BLOOD GLUCOSE; C-PEPTIDE; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MODELS, ANIMAL; PRIMATES; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 42649143792     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2008.00463.x     Document Type: Conference Paper

References (7)

1. Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006 12 : 301 304.
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3. Rood PPM, Bottino R, Balamurugan AN et al. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007 83 : 202 210.
4. Phelps CJ, Koike C, Vaught TD et al. Production of α1,3- galactosyltransferase-deficient pigs. Science 2003 299 : 411 414.
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6. Casu A, Bottino R, Balamurugan AN et al. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice American Diabetes Association's 67th Scientific Sessions, June 22-26, 2007, Chicago, IL, poster # 2064-P. Abstract published in Diabetes, 2007;56(6) Supplement 1:A522). Diabetologia 2008 51 : 120 129.
7. Buhler L, Awwad M, Basker M et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation 2000 69 : 2296 2304.