Gene-modified pigs

Xenotransplantation

Volumn 15, Issue 2, 2008, Pages 87-90

  D'Apice, Anthony J F ^a   Cowan, Peter J ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CALCINEURIN INHIBITOR; CD39 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD59 ANTIGEN; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; STEROID; TISSUE FACTOR PATHWAY INHIBITOR;

CLONING; COMPLEMENT ACTIVATION; CONFERENCE PAPER; DIABETES MELLITUS; DNA MODIFICATION; FOOT AND MOUTH DISEASE VIRUS; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; INFLAMMATION; INNATE IMMUNITY; MONKEY; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIMATE; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; GENETIC ENGINEERING; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 42649134134     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2008.00457.x     Document Type: Conference Paper

References (12)

1. Cardona K, Korbutt GS, Milas Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006 12 : 304 306.
2. Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006 12 : 301 303.
3. Bennet W, Groth CG, Larsson R, Nilsson B, Korsgren O. Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes. Ups J Med Sci 2000 105 : 125 133.
4. Ozmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B. Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 2002 51 : 1779 1784.
5. Hering BJ, Kandaswamy R, Harmon JV et al. Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant 2004 4 : 390 401.
6. Ryan EA, Lakey JR, Rajotte RV et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001 50 : 710 719.
7. Sutherland RM, Brady JL, Georgiou FM, Thomas HE, Lew AM. Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts. Transplantation 2000 69 : 1806 1812.
8. Zhan YF, Martin RM, Sutherland RM, Brady JL, Lew AM. Local production of anti-CD4 antibody by transgenic allogeneic grafts affords partial protection. Transplantation 2000 70 : 947 954.
9. Harrison S, Boquest A, Grupen C et al. An efficient method for producing alpha(1,3)-galactosyltransferase gene knockout pigs. Cloning Stem Cells 2004 6 : 327 331.
10. de FP, Ryan MD. Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences. Traffic 2004 5 : 616 626.
11. Fang J, Qian JJ, Yi S et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol 2005 23 : 584 590.
12. Szymczak AL, Workman CJ, Wang Y et al. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol 2004 22 : 589 594.