Bioactive metabolite production and stress-related hormones in Devil's claw cell suspension cultures grown in bioreactors

Applied Microbiology and Biotechnology

Volumn 89, Issue 6, 2011, Pages 1683-1691

  Georgiev, Milen ^a,b   Ludwig Müller, Jutta ^c   Weber, Jost ^c   Stancheva, Nina ^d   Bley, Thomas ^c  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b LEIDEN UNIVERSITY   (Netherlands)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d AGRICULTURAL UNIVERSITY   (Bulgaria)

Author keywords

Harpagophytum procumbens; Indole 3 acetic acid; Phenylethanoid glycosides; Pulse aerated column bioreactor; Stress related hormones

Indexed keywords

ANTI-INFLAMMATORIES; CELL SUSPENSION CULTURES; COLUMN BIOREACTORS; COLUMN REACTORS; HARPAGOPHYTUM PROCUMBENS; HORMONE LEVELS; INDOLE-3-ACETIC ACID; METABOLITE PRODUCTION; PHENYLETHANOID GLYCOSIDES; PHYSIOLOGICAL STATUS; PULSE-AERATED COLUMN BIOREACTOR; SALICYLIC ACIDS; SHAKE-FLASK CULTURES; STEPWISE INCREASE; STIRRED TANK REACTORS; STRESS LEVELS; VERBASCOSIDE;

ACETIC ACID; BIOCONVERSION; BIOREACTORS; BOTTLES; ENDOCRINOLOGY; HORMONES; METAL ANALYSIS; PH; SUGARS; TANKS (CONTAINERS); TISSUE;

CELL CULTURE;

ABSCISIC ACID; ACTEOSIDE; BETA HYDROXY VERBASCOSIDE; INDOLEACETIC ACID; JASMONIC ACID; LEUCOSCEPTOSIDE A; PHYTOHORMONE; SALICYLIC ACID; UNCLASSIFIED DRUG;

BIOREACTOR; CULTIVATION; HORMONE; MEDICINAL PLANT; METABOLITE;

ARTICLE; BIOMASS; BIOREACTOR; HARPAGOPHYTUM PROCUMBENS; HORMONE DETERMINATION; METABOLITE; PEDALIACEAE; PLANT CELL; PLANT GROWTH; PULSE AERATED COLUMN BIOREACTOR; SHEAR STRESS; STIRRED REACTOR;

BIOLOGICAL FACTORS; BIOREACTORS; CELLS, CULTURED; GLUCOSIDES; HARPAGOPHYTUM; PHENOLS;

HARPAGOPHYTUM PROCUMBENS;

EID: 79952575862     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-3008-2     Document Type: Article

References (33)

1. Balbi V, Devoto A (2008) Jasmonate signalling network in Arabidopsis thaliana: crucial regulatory nodes and new physiological scenarios. New Phytol 177:301-318 (Pubitemid 350295787)
2. Cheong J-J (2000) Phytoalexin biosynthesis as a model system for biochemistry of plant-microbe interaction. Plant Pathol J 16:70-78
3. Cohen JD (1984) Convenient apparatus for the generation of small amounts of diazomethane. J Chromatogr 303:193-196
4. Cohen JD, Baldi BG, Slovin JP (1986) 13 C6-[benzene ring] - Indole-3-acetic acid. Plant Physiol 80:14-19
5. D'Onofrio C, Cox A, Davies C, Boss PK (2009) Induction of secondary metabolism in grape cell cultures by jasmonates. Funct Plant Biol 36:323-338
6. Davies PJ (ed) (2010) Plant hormones: biosynthesis, signal transduction, action!, revised 3rd ed. Springer, Dordrecht
7. Eibl R, Eibl D (2008) Design of bioreactors suitable for plant cell and tissue culture. Phytochem Rev 7:593-598
8. Eibl R, Kaiser S, Lombriser R, Eibl D (2010) Disposable bioreactors: the current state-of-art and the recommended applications in biotechnology. Appl Microbiol Biotechnol 86:41-49
9. Estrada-Zuniga ME, Cruz-Sosa F, Rodriguez-Monroy M, Verde-Calvo JR, Vernon-Carter EJ (2009) Phenylpropanoid production in callus and cell suspension cultures of Buddleja cordata Kunth. Plant Cell Tissue Organ Cult 97:39-47
10. Gagné S, Cluzet S, Mérillon J-M, Gény L (2010) ABA initiates anthocyanin production in grape cell cultures. J Plant Growth Regul. doi:10.1007/s00344-010-9165-9
11. Georgiev M, Weber J, Maciuk A (2009) Bioprocessing of plant cell cultures for mass production of targeted compounds. Appl Microbiol Biotechnol 83:809-823
12. Georgiev M, Alipieva K, Pashova S, Denev P, Angelova M, Kerns G, Bley T (2010) Antioxidant activity of Devil's claw cell biomass and its active constituents. Food Chem 121:967-972
13. Gyurkovska V, Alipieva K, Maciuk A, Dimitrova P, Ivanovska N, Haas C, Bley T, Georgiev M (2010) Anti-inflammatory activity of devil's claw in vitro systems and their active constituents. Food Chem 125:171-178
14. Haas C, Weber J, Ludwig-Müller J, Deponte S, Bley T, Georgiev M (2008) Flow cytometry and phytochemical analysis of a sunflower cell suspension culture in a 5-L bioreactor. Z Naturforsch 63c:699-705
15. Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of recombinant proteins. Nat Biotechnol 22:1415-1422 (Pubitemid 39482861)
16. Linsmayer EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18:100-127
17. Loake G, Grant M (2007) Salicylic acid in plant defence - the players and protagonists. Curr Opin Plant Biol 10:466-472 (Pubitemid 47520606)
18. Lu C-T, Mei X-G (2003) Improvement of phenylethanoid glycosides production by a fungal elicitor in cell suspension culture of Cistanche deserticola. Biotechnol Lett 25:1437-1439 (Pubitemid 37065294)
19. Ludwig-Müller J, Schubert B, Pieper K, Ihmig S, Hilgenberg W (1997) Glucosinolate content in susceptible and tolerant Chinese cabbage varieties during the development of the clubroot disease. Phytochemistry 44:407-414 (Pubitemid 27100298)
20. Ludwig-Müller J, Georgiev M, Bley T (2008) Metabolite and hormonal status of hairy root cultures of Devil's claw (Harpagophytum procumbens) in flasks and in a bubble column bioreactor. Process Biochem 43:15-23 (Pubitemid 350257022)
21. Nitzsche A, Tokalov SV, Gutzeit HO, Ludwig-Müller J (2004) Chemical and biological characterization of cinnamic acid derivatives from cell cultures of lavender (Lavandula officinalis) induced by stress and jasmonic acid. J Agric Food Chem 52:2915-2923
22. Perez JAS, Porcel EMR, Lopez JLC, Sevilla JMF, Chisti Y (2006) Shear rate in stirred tank and bubble column bioreactors. Chem Eng J 124:1-5
23. Smith JL, De Moraes CM, Mescher MC (2009) Jasmonate- and salicylate-mediated plant defense responses to insect herbivores, pathogens and parasitic plants. Pest Manag Sci 65:497-503
24. Stancheva N, Weber J, Schulze J, Alipieva K, Ludwig-Müller J, Haas C, Georgiev V, Bley T, Georgiev M (2010) Phytochemical and flow cytometric analyses of devil's claw cell cultures. Plant Cell Tissue Organ Cult. doi:10.1007/s11240-010-9844-z
25. Terrier B, Courtois D, Henault N, Cuvier A, Bastin M, Aknin A, Dubreuil J, Petiard V (2007) Two new disposable bioreactors for plant cell culture: the wave and undertow bioreactor and the slug bubble bioreactor. Biotechnol Bioeng 96:914-923 (Pubitemid 46479554)
26. Thaler JS, Owen B, Higgins VJ (2004) The role of the jasmonate response in plant susceptibility to diverse pathogens with a range of lifestyles. Plant Physiol 135:530-538 (Pubitemid 38653697)
27. Tuteja N (2007) Abscisic acid and abiotic stress signaling. Plant Signal Behav 2:135-138
28. Verpoorte R, Contin A, Memelink J (2002) Biotechnology for the production of plant secondary metabolites. Phytochem Rev 1:13-25 (Pubitemid 41400498)
29. Wasternack C, Hause B (2002) Jasmonates and octadecanoids: signals in plant stress responses and development. Prog Nucleic Acid Res Mol Biol 72:165-221
30. Wells G, Huston C (1995) High-resolution selected ion monitoring in a quadrupole ion trap mass spectrometer. Anal Chem 67:3650-3655
31. Werner S, Eibl R, Lettenbauer C, Röll M, Eibl D, De Jesus M, Zhang X, Stettler M, Tissot S, Bürki C, Broccard G, Kühner M, Tanner R, Hacker D, Wurm FM (2010) Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers - a Swiss contribution. Chimia (in press)
32. Zhong J-J (2001) Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures. In: Scheper T, Zhong JJ (eds) Advances in biochemical engineering/biotechnology, vol 72, plant cells. Springer, Berlin, pp 1-26
33. Zhou T-C, Zhou W-W, Hu W, Zhong J-J (2010) Bioreactors, cell culture, commercial production. In: Flickinger MC (ed) Encyclopedia of industrial biotechnology: bioprocess, bioseparation, and cell technology. Wiley, New York, pp 3883-3912