Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice

Alzheimer's Research and Therapy

Volumn 3, Issue 2, 2011, Pages

  Li, Bin ^a   Gonzalez Toledo, Maria E ^a   Piao, Chun Shu ^a   Gu, Allen ^b   Kelley, Roger E ^a,c   Zhao, Li Ru ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b RICE UNIVERSITY   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; HEMOPOIETIC GROWTH FACTOR; PROTEIN; STEM CELL FACTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; BRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLOW CYTOMETRY; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL MOBILIZATION; TRANSGENIC MOUSE; TREATMENT DURATION;

EID: 79952562384     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/alzrt67     Document Type: Article

References (30)

1. Xu J, Kochanek KD, Murphy SL, Tejada-Vera B, Division of Vital Statistics: Deaths: final data for 2007. National Vital Statistics Reports 2010, 58:19.
2. Yankner BA, Lu T: Amyloid β-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 2009, 284:4755-4759.
3. McGeer PL, McGeer EG: Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 2001, 22:799-809. (Pubitemid 34066546)
4. Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S: Powerful beneficial effects of macrophage colony-stimulating factor on β-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain 2009, 132:1078-1092.
5. Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, Suzumura A: Microglia activated with the tolllike receptor 9 ligand CpG attenuate oligomeric amyloid β neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol 2009, 175:2121-2132.
6. Simard AR, Soulet D, Gowing G, Julien JP, Rivest S: Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006, 49:489-502. (Pubitemid 43221886)
7. Galli SJ, Zsebo KM, Geissler EN: The kit ligand, stem cell factor. Adv Immunol 1994, 55:1-96.
8. Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G: Filgrastim (rmetHuG-CSF): the first 10 years. Blood 1996, 88:1907-1929.
9. Zhao LR, Singhal S, Duan WM, Mehta J, Kessler JA: Brain repair by hematopoietic growth factors in a rat model of stroke. Stroke 2007, 38:2584-2591. (Pubitemid 47329641)
10. Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab S: Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 2003, 34:745-751. (Pubitemid 36307405)
11. Shyu WC, Lin SZ, Yang HI, Tzeng YS, Pang CY, Yen PS, Li H: Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 2004, 110:1847-1854.
12. Zhao LR, Berra HH, Duan WM, Singhal S, Mehta J, Apkarian AV, Kessler JA: Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats. Stroke 2007, 38:2804-2811. (Pubitemid 47494021)
13. Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW: Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience 2009, 163:55-72.
14. Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR: Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 2001, 17:157-165. (Pubitemid 32409891)
15. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR: Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 2004, 13:159-170. (Pubitemid 38111354)
16. ImageJ Software. [http://imagej.nih.gov/ij/download.html].
17. Imai Y, Kohsaka S: Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002, 40:164-174. (Pubitemid 35337374)
18. Edling CE, Hallberg B: c-Kit - a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol 2007, 39:1995-1998. (Pubitemid 47376824)
19. Guth S, Miltenyi S, Schmitz J: Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood [abstract]. Immunol Today 1995, 16 Suppl:s305-s362.
20. de Revel T, Appelbaum FR, Storb R, Schuening F, Nash R, Deeg J, McNiece I, Andrews R, Graham T: Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs. Blood 1994, 83:3795-3799. (Pubitemid 24175571)
21. Hess DA, Levac KD, Karanu FN, Rosu-Myles M, White MJ, Gallacher L, Murdoch B, Keeney M, Ottowski P, Foley R, Chin-Yee I, Bhatia M: Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell factor. Blood 2002, 100:869-878. (Pubitemid 34832612)
22. Piao CS, Gonzalez-Toledo ME, Xue YQ, Duan WM, Terao S, Granger DN, Kelley RE, Zhao LR: The role of stem cell factor and granulocyte-colony stimulating factor in brain repair during chronic stroke. J Cereb Blood Flow Metab 2009, 29:759-770.
23. Simard AR, Rivest S: Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J 2004, 18:998-1000. (Pubitemid 39561504)
24. Corti S, Locatelli F, Strazzer S, Salani S, Del Bo R, Soligo D, Bossolasco P, Bresolin N, Scarlato G, Comi GP: Modulated generation of neuronal cells from bone marrow by expansion and mobilization of circulating stem cells with in vivo cytokine treatment. Exp Neurol 2002, 177:443-452. (Pubitemid 35366133)
25. Chan WY, Kohsaka S, Rezaie P: The origin and cell lineage of microglia: new concepts. Brain Res Rev 2007, 53:344-354. (Pubitemid 46177241)
26. Cameron B, Landreth GE: Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis 2010, 37:503-509.
27. Combs CK: Inflammation and microglia actions in Alzheimer's disease. J Neuroimmune Pharmacol 2009, 4:380-388.
28. Leung E, Guo L, Bu J, Maloof M, Khoury JE, Geula C: Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex. Neurobiol Aging 2009, 32:387-397.
29. Laske C, Stellos K, Stransky E, Seizer P, Akcay O, Eschweiler GW, Leyhe T, Gawaz M: Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease. J Alzheimers Dis 2008, 15:451-460.
30. Laske C, Stellos K, Stransky E, Leyhe T, Gawaz M: Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease. J Alzheimers Dis 2009, 17:115-123.