Nuclear β-catenin expression and Wnt signalling: In defence of the dogma

Journal of Pathology

Volumn 221, Issue 3, 2010, Pages 239-241

  Fodde, Riccardo ^a   Tomlinson, Ian ^b  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

catenin (CTNNB1); Adenomatous polyposis coli (APC); Colon cancer; KRAS; Wnt signalling

Indexed keywords

APC PROTEIN; B RAF KINASE; BETA CATENIN; T CELL FACTOR PROTEIN; WNT PROTEIN;

APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; COLORECTAL CANCER; FAMILIAL COLON POLYPOSIS; GENE MUTATION; GENETIC STABILITY; HUMAN; LOSS OF FUNCTION MUTATION; NONHUMAN; NOTE; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENOMATOUS POLYPOSIS COLI; BETA CATENIN; CELL NUCLEUS; GENES, APC; HUMANS; MUTATION; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 77953492385     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2718     Document Type: Note

References (15)

1. Phelps RA, Chidester S, Dehghanizadeh S, et al . A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 2009; 137: 623-634.
2. Obrador-Hevia A, Suet-Feung C, Gonzales S, et al . Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas. J Pathol 2010; 221: 57-67.
3. Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 2001; 1: 55-67. (Pubitemid 33741881)
4. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434: 843-850. (Pubitemid 40558990)
5. Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear β-catenin from TCF. Dev Cell 2004; 7: 677-685. (Pubitemid 39462688)
6. Bos JL, Fearon ER, Hamilton SR, et al . Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293-297.
7. Forrester K, Almoguera C, Han K, et al . Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 1987; 327: 298-303. (Pubitemid 17075080)
8. Barker N, van den Born M. Detection of β-catenin localization by immunohistochemistry. Methods Mol Biol 2008; 468: 91-98.
9. Molenaar M, van de Wetering M, Oosterwegel M, et al . XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 1996; 86: 391-399. (Pubitemid 26272079)
10. Yan D, Wiesmann M, Rohan M, et al . Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors. Proc Natl Acad Sci USA 2001; 98: 14973-14978.
11. Janssen KP, Alberici P, Fsihi H, et al . APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 2006; 131: 1096-1109.
12. Brabletz T, Jung A, Hermann K, et al . Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998; 194: 701-704. (Pubitemid 28523944)
13. Fodde R, Brabletz T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007; 19: 150-158. (Pubitemid 46386404)
14. Segditsas S, Rowan AJ, Howarth K, et al . APC and the three-hit hypothesis. Oncogene 2009; 28: 146-155.
15. Anderson CB, Neufeld KL, White RL. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci USA 2002; 99: 8683-8688.