메뉴 건너뛰기




Volumn 2, Issue 2, 2010, Pages 207-216

Study of valproic acid-induced endogenous and exogenous metabolite alterations using LC-MS-based metabolomics

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; VALPROIC ACID; VALPROIC ACID DERIVATIVE; AMINO ACID; ANTICONVULSIVE AGENT;

EID: 79952514795     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.09.173     Document Type: Article
Times cited : (22)

References (41)
  • 2
    • 0028906843 scopus 로고
    • A clinically significant interaction between clozapine and valproate
    • Costello LE, Suppes T. A clinically significant interaction between clozapine and valproate. J. Clin. Psychopharmacol. 15, 139-41 (1995).
    • (1995) J. Clin. Psychopharmacol. , vol.15 , pp. 139-41
    • Costello, L.E.1    Suppes, T.2
  • 4
    • 0029925182 scopus 로고    scopus 로고
    • Valproic acid hepatic fatalities. III. U.S. experience since 1986
    • Bryant AE 3rd, Dreifuss FE. Valproic acid hepatic fatalities. III. US experience since 1986. Neurology 46, 465-469 (1996). (Pubitemid 26081333)
    • (1996) Neurology , vol.46 , Issue.2 , pp. 465-469
    • Bryant III, A.E.1    Dreifuss, F.E.2
  • 5
    • 0018379006 scopus 로고
    • Reye-like syndrome associated with valproic acid therapy
    • DOI 10.1016/S0022-3476(79)80110-9
    • Gerber N, Dickinson RG, Harland RC, et al. Reye-like syndrome associated with valproic acid therapy. J. Pediatr. 95, 142-144 (1979). (Pubitemid 9183702)
    • (1979) Journal of Pediatrics , vol.95 , Issue.1 , pp. 142-144
    • Gerber, N.1    Dickinson, R.G.2    Harland, R.C.3
  • 6
    • 0141758494 scopus 로고    scopus 로고
    • 2002 annual report of the American association of poison control centers toxic exposure surveillance system
    • Watson WA, Litovitz TL, Rodgers GCJ, et al. 2002 annual report of the American association of poison control centers toxic exposure surveillance system. Am. J. Emerg. Med. 21, 353-421 (2003).
    • (2003) Am. J. Emerg. Med. , vol.21 , pp. 353-421
    • Watson, W.A.1    Litovitz, T.L.2    Gcj, R.3
  • 7
    • 0027942318 scopus 로고
    • Renal tubular dysfunction following treatment with anti-epileptic drugs
    • DOI 10.1007/s004310050230
    • Korinthenberg R, Wehrle L, Zimmerhackl LB. Renal tubular dysfunction following treatment with anti-epileptic drugs. Eur. J. Pediatr. 153, 855-858 (1994). (Pubitemid 24314760)
    • (1994) European Journal of Pediatrics , vol.153 , Issue.11 , pp. 855-858
    • Korinthenberg, R.1    Wehrle, L.2    Zimmerhackl, L.B.3
  • 8
    • 33845667452 scopus 로고    scopus 로고
    • Evaluation of renal tubular function in children taking anti-epileptic treatment
    • DOI 10.1111/j.1440-1797.2006.00699.x
    • Unay B, Akin R, Sarici SU, Gok F, Kurt I, Gokcay E. Evaluation of renal tubular function in children taking anti-epileptic treatment. Nephrology (Carlton) 11, 485-488 (2006). (Pubitemid 44951226)
    • (2006) Nephrology , vol.11 , Issue.6 , pp. 485-488
    • Unay, B.1    Akin, R.2    Sarici, S.U.3    Gok, F.4    Kurt, I.5    Gokcay, E.6
  • 9
    • 14844310922 scopus 로고    scopus 로고
    • Extracorporeal management of valproic acid toxicity: A case report and review of the literature
    • Al Aly Z, Yalamanchili P, Gonzalez E. Extracorporeal management of valproic acid toxicity: a case report and review of the literature. Semin Dial. 18, 62-626 (2005).
    • (2005) Semin Dial. , vol.18 , pp. 62-626
    • Al Aly, Z.1    Yalamanchili, P.2    Gonzalez, E.3
  • 10
    • 0020420283 scopus 로고
    • Valproate induced hepatic injury: Analyses of 23 fatal cases
    • Zimmerman HJ, Ishak KG. Valproate-induced hepatic injury: analyses of 23 fatal cases. Hepatology 2, 591-597 (1982). (Pubitemid 13173942)
    • (1982) Hepatology , vol.2 , Issue.5 , pp. 591-597
    • Zimmerman, H.J.1    Ishak, K.G.2
  • 11
    • 0008463096 scopus 로고    scopus 로고
    • Chemistry and biotransformation. Valproate. Milestones in Drug Therapy
    • Verlag, Basel, Switzerland
    • Abbott FS, Anari MR. Chemistry and biotransformation. In: Valproate. Milestones in Drug Therapy. Birkhäuser Verlag, Basel, Switzerland. 47-75 (1999).
    • (1999) Birkhäuser , pp. 47-75
    • Abbott, F.S.1    Anari, M.R.2
  • 13
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • DOI 10.1093/toxsci/kfi102
    • Robertson DG. Metabonomics in toxicology: a review. Toxicol. Sci. 85, 809-822 (2005). (Pubitemid 40846857)
    • (2005) Toxicological Sciences , vol.85 , Issue.2 , pp. 809-822
    • Robertson, D.G.1
  • 14
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668-676 (2003). (Pubitemid 37361770)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 15
  • 16
    • 0345095459 scopus 로고    scopus 로고
    • Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids
    • Plumb RS, Stumpf CL, Granger JH, Castro-Perez J, Haselden JN, Dear GJ. Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids. Rapid Commun. Mass Spectrom. 17, 2632-2638 (2003). (Pubitemid 37498776)
    • (2003) Rapid Communications in Mass Spectrometry , vol.17 , Issue.23 , pp. 2632-2638
    • Plumb, R.S.1    Stumpf, C.L.2    Granger, J.H.3    Castro-Perez, J.4    Haselden, J.N.5    Dear, G.J.6
  • 18
    • 58249098422 scopus 로고    scopus 로고
    • Serum indoxyl sulfate levels in patients with diabetic nephropathy: Relation to renal function
    • Atoh K, Itoh H, Haneda M. Serum indoxyl sulfate levels in patients with diabetic nephropathy: relation to renal function. Diabetes Res. Clin. Pract. 83, 220-226 (2009).
    • (2009) Diabetes Res. Clin. Pract. , vol.83 , pp. 220-226
    • Atoh, K.1    Itoh, H.2    Haneda, M.3
  • 19
    • 0038347142 scopus 로고    scopus 로고
    • Amino acid conjugates: Metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients
    • DOI 10.1124/dmd.31.1.114
    • Gopaul VS, Tang W, Farrell K, Abbott FS. Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients. Drug Metab. Dispos. 31, 114-121 (2003). (Pubitemid 36735265)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.1 , pp. 114-121
    • Gopaul, V.S.1    Tang, W.2    Farrell, K.3    Abbott, F.S.4
  • 20
    • 0020512410 scopus 로고
    • The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats
    • DOI 10.1016/0006-2952(83)90054-0
    • Turnbull DM, Bone AJ, Bartlett K, Koundakjian PP, Sherratt HS. The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats. Biochem. Pharmacol. 32, 1887-1892 (1983). (Pubitemid 13067966)
    • (1983) Biochemical Pharmacology , vol.32 , Issue.12 , pp. 1887-1892
    • Turnbull, D.M.1    Bone, A.J.2    Bartlett, K.3
  • 21
    • 34547778398 scopus 로고    scopus 로고
    • The metabolomics standards iniative (MSI)
    • MSI Board Members, Sansone SA, Fan T, et al. The metabolomics standards iniative (MSI). Nat. Biotechnol. 25, 846-848 (2007).
    • (2007) Nat. Biotechnol. , vol.25 , pp. 846-848
    • Sansone, S.A.1    Fan, T.2
  • 22
    • 33847414492 scopus 로고    scopus 로고
    • Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: A new tool for lipidomics
    • DOI 10.1021/pr060611b
    • Rainville PD, Stumpf CL, Shockcor JP, Plumb RS, Nicholson JK. Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: a new tool for lipidomics. J. Proteome Res. 6, 552-558 (2007). (Pubitemid 46340159)
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 552-558
    • Rainville, P.D.1    Stumpf, C.L.2    Shockcor, J.P.3    Plumb, R.S.4    Nicholson, J.K.5
  • 23
    • 0031017391 scopus 로고    scopus 로고
    • A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its α-fluorinated analogue: Phase II metabolism and pharmacokinetics
    • Tang W, Abbott FS. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its a-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab. Dispos. 25, 219-227 (1997). (Pubitemid 27086123)
    • (1997) Drug Metabolism and Disposition , vol.25 , Issue.2 , pp. 219-227
    • Tang, W.1    Abbott, F.S.2
  • 24
    • 0025971003 scopus 로고
    • Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans
    • Kassahun K, Farrell K, Abbott F. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans. Drug Metab. Dispos. 19, 525-535 (1991).
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 525-535
    • Kassahun, K.1    Farrell, K.2    Abbott, F.3
  • 25
    • 0025317268 scopus 로고
    • Glutathione: Toxicological implications
    • Reed DJ. Glutathione: toxicological implications. Annu. Rev. Pharmacol. Toxicol. 30, 603-631 (1990).
    • (1990) Annu. Rev. Pharmacol. Toxicol. , vol.30 , pp. 603-631
    • Reed, D.J.1
  • 26
    • 0023694528 scopus 로고
    • Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-N-propyl-4-pentenoic acid
    • Baillie TA. Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-N-propyl-4-pentenoic acid. Chem. Res. Toxicol. 1, 195-199 (1988).
    • (1988) Chem. Res. Toxicol. , vol.1 , pp. 195-199
    • Baillie, T.A.1
  • 28
    • 0037392343 scopus 로고    scopus 로고
    • Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    • Rios LY, Gonthier MP, Rémésy C, et al. Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am. J. Clin. Nutr. 77, 912-918 (2003).
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 912-918
    • Rios, L.Y.1    Gonthier, M.P.2    Rémésy, C.3
  • 29
    • 0036810287 scopus 로고    scopus 로고
    • Renal injury from valproic acid: Case report and literature review
    • DOI 10.1016/S0887-8994(02)00447-2, PII S0887899402004472
    • Zaki EL, Springate JE. Renal injury from valproic acid: case report and literature review. Pediatr. Neurol. 27, 318-319 (2002). (Pubitemid 35341708)
    • (2002) Pediatric Neurology , vol.27 , Issue.4 , pp. 318-319
    • Zaki, E.L.1    Springate, J.E.2
  • 30
    • 33745275155 scopus 로고    scopus 로고
    • Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion
    • DOI 10.1111/j.1542-4758.2006.00105.x
    • Rahman MH, Haqqie SS, McGoldrick MD. Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion. Hemodial. Int. 10, 256-259 (2006). (Pubitemid 43923208)
    • (2006) Hemodialysis International , vol.10 , Issue.3 , pp. 256-259
    • Rahman, M.H.1    Haqqie, S.S.2    McGoldrick, M.D.3
  • 31
    • 0011501687 scopus 로고    scopus 로고
    • Cystinosis and Fanconi syndrome
    • Barratt T, Avner E, Harmon W (Eds). Lippincott Williams and Wilkins, MD, USA
    • Foreman J. Cystinosis and Fanconi syndrome. In: Pediatric Nephrology. Barratt T, Avner E, Harmon W (Eds). Lippincott Williams and Wilkins, MD, USA, 593-605 (1999).
    • (1999) Pediatric Nephrology , pp. 593-605
    • Foreman, J.1
  • 32
    • 33645949094 scopus 로고    scopus 로고
    • An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms
    • Schnackenberg LK, Jones RC, Thyparambil S, et al. An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms. OMICS 10, 1-14 (2006).
    • (2006) OMICS , vol.10 , pp. 1-14
    • Schnackenberg, L.K.1    Jones, R.C.2    Thyparambil, S.3
  • 33
    • 70149102426 scopus 로고    scopus 로고
    • Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupts glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6] -d-glucose tracer in mice
    • Beger RD, Hansen DK, Schnackenberg LK, et al. Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupts glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6]-d-glucose tracer in mice. Metabolomics 5, 336-345 (2009).
    • (2009) Metabolomics , vol.5 , pp. 336-345
    • Beger, R.D.1    Hansen, D.K.2    Schnackenberg, L.K.3
  • 34
    • 58249098422 scopus 로고    scopus 로고
    • Serum indoxyl sulfate levels in patients with diabetic nephropathy: Relation to renal function
    • Atoh K, Itoh H, Haneda M. Serum indoxyl sulfate levels in patients with diabetic nephropathy: relation to renal function. Diabetes Res. Clin. Pract. 83, 220-226 (2009).
    • (2009) Diabetes Res. Clin. Pract. , vol.83 , pp. 220-226
    • Atoh, K.1    Itoh, H.2    Haneda, M.3
  • 36
    • 0028980671 scopus 로고
    • 3,5-dichloroaniline toxicity in Fischer 344 rats pretreated with inhibitors and inducers of cytochrome P450
    • Valentovic MA, Lo HH, Brown PI, Rankin GO. 3,5-dichloroaniline toxicity in Fischer 344 rats pretreated with inhibitors and inducers of cytochrome P450. Toxicol. Lett. 78, 207-214 (1995).
    • (1995) Toxicol. Lett. , vol.78 , pp. 207-214
    • Valentovic, M.A.1    Lo, H.H.2    Brown, P.I.3    Rankin, G.O.4
  • 37
    • 0022653954 scopus 로고
    • 3,5-dichloroaniline-induced nephrotoxicity in the Sprague-Dawley rat
    • Rankin GO, Yang DJ, Teets VJ, Lo HH, Brown PI. 3,5-dichloroaniline- induced nephrotoxicity in the Sprague-Dawley rat. Toxicol. Lett. 30, 173-179 (1986).
    • (1986) Toxicol. Lett. , vol.30 , pp. 173-179
    • Rankin, G.O.1    Yang, D.J.2    Teets, V.J.3    Lo, H.H.4    Brown, P.I.5
  • 40
    • 59149103599 scopus 로고    scopus 로고
    • Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies
    • Schnackenberg LK, Chen M, Sun J, et al. Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies. Toxicol. Appl. Pharmacol. 235(1), 25-32 (2008).
    • (2008) Toxicol. Appl. Pharmacol. , vol.235 , Issue.1 , pp. 25-32
    • Schnackenberg, L.K.1    Chen, M.2    Sun, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.