Carvedilol inhibits activation of stress-activated protein kinase and reduces reperfusion injury in perfused rabbit heart

European Journal of Pharmacology

Volumn 345, Issue 1, 1998, Pages 61-65

  Yue, Tian Li ^a   Ma, Xin Liang ^b   Gu, Juan Li ^a   Ruffolo Jr, Robert R ^a   Feuerstein, Giora Z ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

adrenoceptor antagonist; Cardiac; Carvedilol; Ischemia reperfusion; JNK (c Jun N terminal kinase); SAPK (stress activated protein kinase)

Indexed keywords

ANTIOXIDANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CREATINE KINASE; DRUG VEHICLE; GLUTATHIONE TRANSFERASE; PROTEIN KINASE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG POTENCY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBAZOLES; ENZYME INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PROPANOLAMINES; PROTO-ONCOGENE PROTEINS C-JUN; RABBITS;

EID: 0032510588     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00053-3     Document Type: Article

References (21)

1. Bogoyevitch M.A., Gillespie-Brown J., Ketterman A., Fuller S.J., Ben-Levy R., Ashworth A., Marshall C.J., Sugden P.H. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. Circ. Res. 79:1996;162-173.
2. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1037.
3. Feuerstein G.Z., Shusterman N.H., Ruffolo R.R. Jr. Carvedilol update: IV. Prevention of oxidative stress, cardiac remodeling and progression of congestive heart failure. Drugs Today. 33:1997;453-473.
4. Force T., Pombo C.M., Avruch J.A., Bonventre J.V., Kyriakis J.M. Stress-activated protein kinases in cardiovascular disease. Circ. Res. 78:1996;947-953.
5. Hibi M., Lin A., Smeal T., Minden A., Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:1993;2135-2148.
6. Knight R.J., Buxton D.B. Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischemia and reperfusion in the perfused rat heart. Biochem. Biophys. Commun. 218:1996;83-88.
7. Komuro I., Kudo S., Yamazaki T., Zou Y., Shiojima I., Yazaki Y. Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes. FASEB J. 10:1996;631-636.
8. Kyriakis J.M., Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:1996;24313-24316.
9. Kyriakis J.M., Banerjee P., Nikolakaki E. The stress-activated protein kinase subfamily of c-jun kinase. Nature. 369:1994;156-160.
10. Lefer A.M., Tsao P.S., Ma X.L., Sampath T.K. Anti-ischemic and endothelial protective actions of recombinant human osteogenic protein (hOP-1). J. Mol. Cell. Cardiol. 24:1992;585-593.
11. Lefer D.J., Shandelya S.M.L., Serrano C.V. Jr., Becker L.C., Kuppusamy P., Zweier J.L. Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury. Circulation. 88:1993;1779-1787.
12. McPhillips J.J., Schwemer G.T., Scott D.I., Zinny M., Patterson D. Effects of carvedilol on blood pressure in patients with mild to moderate hypertension. Drugs. 36(Suppl. 6):1988;82-91.
13. Packer M., Bristow M.R., Cohn J.N., Colucci W.S., Fowler M.B., Gilber E.M., Shusterman N.H. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. New Engl. J. Med. 334:1996;1349-1397.
14. Ruffolo Jr R.R., Boyle D., Venuit R.P., Lukas M. Carvedilol (Kredex): a novel multiple action cardiovascular agent. Drugs Today. 27:1991;465-492.
15. Sato H., Zhao Z.Q., McGee D.S., Williams M.W., Hammon J.W. Jr., Vinten-Johansen J. Supplemental L-arginine during cardioplegic arrest and reperfusion avoids reginal postischemic injury. J. Thorac. Cardiovasc. Surg. 110:1995;302-314.
16. + exchanger inhibitors. Am. J. Physiol. 270:1996;H692-700.
17. Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide-initiated SAPK/JUK signaling in stress-induced apoptosis. Nature. 380:1996;75-79.
18. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
19. Yin T., Sandhu G., Walfgang C.D., Burrier A., Webb R.L., Rigel D.F., Hai T., Whelan J. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J. Biol. Chem. 272:1997;19943-19950.
20. Yue T.L., Cheng H.Y., Lysko P.G., MccKenna P.J., Feuerstein R., Gu J.L., Lysko K.A., Davis L.L., Feuerstein G.Z. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. J. Pharmacol. Exp. Ther. 263:1992;92-98.
21. Yue T.L., Wang X.K., Louden C.S., Gupta S., Pillarisetti K., Gu J.L., Hart T.K., Lysko P.G., Feuerstein G.Z. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol. Pharmacol. 51:1997;951-962.