Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method

Bioanalysis

Volumn 2, Issue 4, 2010, Pages 745-753

  Browning, Marc R ^a,b   Drexler, Dieter M ^b   Olah, Timothy V ^b   Morgan, Daniel G ^b  

^a Pharmaceutical Candidate Optimization ^*  (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; FOSAMPRENAVIR; CARBAMIC ACID DERIVATIVE; ORGANOPHOSPHATE; PHOSPHATE; PRODRUG; SULFONAMIDE;

ANALYTIC METHOD; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; IONIZATION; LAMINAR FLOW; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; TURBULENT FLOW; ANIMAL; BLOOD; CHEMICAL PHENOMENA; CHEMISTRY; DRUG STABILITY; MALE; METHODOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; CARBAMATES; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MASS SPECTROMETRY; PHOSPHATES; PHOSPHORIC ACID ESTERS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TIME FACTORS;

EID: 79952483635     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.25     Document Type: Article

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