The use of turbulent flow chromatography and the isocratic focusing effect to achieve on-line cleanup and concentration of neat biological samples for low-level metabolite analysis

Rapid Communications in Mass Spectrometry

Volumn 19, Issue 5, 2005, Pages 696-700

  Herman, J L ^a  

^a CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; COLUMN CHROMATOGRAPHY; FOCUSING; TURBULENT FLOW;

BIOLOGICAL SAMPLES; COLUMN SWITCHING; FOCUSING EFFECT; ISOCRATIC; METABOLITE ANALYSIS; MULTIPLE INJECTIONS; RAT PLASMA; SAMPLE CLEAN-UP; SAMPLE CONCENTRATION; TURBULENT FLOW CHROMATOGRAPHIES;

METABOLITES;

ARTICLE; AUTOMATION; CHEMICAL ANALYSIS; CHROMATOGRAPHY; ELUTION; EXTRACTION; MASS SPECTROMETER; METABOLITE; NONHUMAN; PLASMA; RAT; TURBULENT FLOW;

EID: 14744301655     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1843     Document Type: Article

References (21)

1. Ayrton J, Dear GJ, Leavens WJ, Mallett DN, Plumb RS. Rapid Commun. Mass Spectrom. 1997; 11: 1953.
2. Ayrton J, Dear GJ, Leavens WJ, Mallett DN, Plumb RS. J. Chromatogr. A 1998; 828: 199.
3. Jemal M, Xia Y-Q, Whigan DB. Rapid Commun. Mass Spectrom. 1998; 12: 1389.
4. Jemal M. Biomed. Chromatogr. 2000; 14: 422.
5. Powell ML, Jemal M. Am. Pharm. Rev. 2001; 4: 63.
6. Hsieh Y, Bryant MS, Gruela G, Brissom J-M, Korfmacher WA. Rapid Commun. Mass Spectrom. 2000; 14: 1384.
7. Mallet CR, Mazzeo JR, Neue U. Rapid Commun. Mass Spectrom. 2001; 15: 1075.
8. Jemal M, Ouyang Z, Xia Y-Q, Powell ML. Rapid Commun. Mass Spectrom. 1999; 13: 1462.
9. Jemal M, Huang M, Jiang X, Mao Y, Powell ML. Rapid Commun. Mass Spectrom. 1999; 13: 2125.
10. Jemal M, Xia Y-Q. J. Pharm. Biomed. Anal. 2000; 22: 813.
11. Zeng H, Wu J-T, Unger SE. J. Pharm. Biomed. Anal. 2002; 27: 967.
12. Kollroser M, Schober C. Rapid Commun. Mass Spectrom. 2002; 16: 1266.
13. Lim HK, Chan KW, Sisenwine S, Scatins JA. Anal. Chem. 2001; 73: 2140.
14. Takino M, Daishima S, Nakahara T. Rapid Commun. Mass Spectrom. 2003; 17: 383.
15. Hsieh S, Tobien T, Koch K, Dunn J. Rapid Commun. Mass Spectrom. 2004; 18: 285.
16. Grant RP, Cameron C, Mackenzie-McMurter S. Rapid Commun. Mass Spectrom. 2002; 16: 1785.
17. Bringnol N, Bakhtir R, Dou L, Majumdar T, Tse FLS. Rapid Commun. Mass Spectrom. 2000; 14: 141.
18. Ramos L, Bringnol N, Bakhtir R, Ray T, McMahon LM, Tse FSE. Rapid Commun. Mass Spectrom. 2000; 14: 2282.
19. Wu J-T, Zeng H, Qian M, Brogdon BL, Unger SE. Anal. Chem. 2000; 72: 61.
20. Herman JL. Rapid Commun. Mass Spectrom. 2002; 16: 421.
21. Herman JL. Int. J. Mass Spectrom. Special Issue: Drug Discovery 2004; 238: 107.