메뉴 건너뛰기




Volumn 17, Issue 4, 2011, Pages 899-906

Neonatal exposure to fecal antigens reduces intestinal inflammation

Author keywords

Bacterial antigens; Hygiene hypothesis; IL 10; Inflammatory bowel disease; Neonatal tolerization

Indexed keywords

BACTERIAL ANTIGEN; BACTERIUM LYSATE; CD11B ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17;

EID: 79952468893     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21453     Document Type: Article
Times cited : (5)

References (52)
  • 1
    • 0037136586 scopus 로고    scopus 로고
    • Eat dirt - The hygiene hypothesis and allergic diseases
    • Weiss ST. Eat dirt - the hygiene hypothesis and allergic diseases. N Engl J Med. 2002;347:930-931.
    • (2002) N Engl J Med , vol.347 , pp. 930-931
    • Weiss, S.T.1
  • 2
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299: 1259-1260. (Pubitemid 19280051)
    • (1989) British Medical Journal , vol.299 , Issue.6710 , pp. 1259-1260
    • Strachan, D.P.1
  • 3
    • 33646175398 scopus 로고    scopus 로고
    • The 'microflora hypothesis' of allergic diseases
    • Noverr MC, Huffnagle GB. The 'microflora hypothesis' of allergic diseases. Clin Exp Allergy. 2005;35:1511-1520.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1511-1520
    • Noverr, M.C.1    Huffnagle, G.B.2
  • 5
    • 33745369494 scopus 로고    scopus 로고
    • Neonatal exposure with LPS and/or allergen prevents experimental allergic airways disease: Development of tolerance using environmental antigens
    • DOI 10.1016/j.jaci.2006.03.020, PII S0091674906007251
    • Wang Y and McCusker C. Neonatal exposure with LPS and/or allergen prevents experimental allergic airways disease: development of tolerance using environmental antigens. J Allergy Clin Immunol. 2006; 118:143-151. (Pubitemid 43946471)
    • (2006) Journal of Allergy and Clinical Immunology , vol.118 , Issue.1 , pp. 143-151
    • Wang, Y.1    McCusker, C.2
  • 6
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine twins
    • Owen RD. Immunogenetic consequences of vascular anastomoses between bovine twins. Science. 1945;102:400-401.
    • (1945) Science , vol.102 , pp. 400-401
    • Owen, R.D.1
  • 7
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 1953;172:603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 8
    • 22944433876 scopus 로고    scopus 로고
    • The success and failure of BCG - Implications for a novel tuberculosis vaccine
    • DOI 10.1038/nrmicro1211
    • Andersen P, Doherty TM. The success and failure of BCG - implications for a novel tuberculosis vaccine. Nat Rev Microbiol. 2005;3: 656-662. (Pubitemid 41052152)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.8 , pp. 656-662
    • Andersen, P.1    Doherty, T.M.2
  • 9
    • 1642410856 scopus 로고    scopus 로고
    • Hepatitis B virus epidemiology, disease burden, treatment, arid current and emerging prevention and control measures
    • DOI 10.1046/j.1365-2893.2003.00487.x
    • Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97-107. (Pubitemid 38365759)
    • (2004) Journal of Viral Hepatitis , vol.11 , Issue.2 , pp. 97-107
    • Lavanchy, D.1
  • 10
    • 41849112305 scopus 로고    scopus 로고
    • Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants
    • Knuf M, Schmitt HJ, Wolter J, et al. Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants. J Pediatr. 2008;152:655-660.
    • (2008) J Pediatr , vol.152 , pp. 655-660
    • Knuf, M.1    Schmitt, H.J.2    Wolter, J.3
  • 11
    • 0022635695 scopus 로고
    • Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation
    • DOI 10.1038/319413a0
    • Gammon G, Dunn K, Shastri N, et al. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature. 1986;319:413-415. (Pubitemid 16163902)
    • (1986) Nature , vol.319 , Issue.6052 , pp. 413-415
    • Gammon, G.1    Dunn, K.2    Shastri, N.3
  • 12
    • 0025014494 scopus 로고
    • Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells
    • Powell TJ Jr, Streilein JW. Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J Immunol. 1990;144:854-859. (Pubitemid 20065023)
    • (1990) Journal of Immunology , vol.144 , Issue.3 , pp. 854-859
    • Powell Jr., T.J.1    Streilein, J.W.2
  • 13
    • 40749116456 scopus 로고    scopus 로고
    • T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice
    • Fernandez MA, Puttur FK, Wang YM, et al. T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. J Immunol. 2008;180: 1556-1564.
    • (2008) J Immunol , vol.180 , pp. 1556-1564
    • Fernandez, M.A.1    Puttur, F.K.2    Wang, Y.M.3
  • 14
    • 0032833261 scopus 로고    scopus 로고
    • Intestinal inflammation and the gut microflora
    • McKay DM. Intestinal inflammation and the gut microflora. Can J Gastroenterol. 1999;13:509-516.
    • (1999) Can J Gastroenterol , vol.13 , pp. 509-516
    • McKay, D.M.1
  • 16
    • 0036726184 scopus 로고    scopus 로고
    • Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens
    • DOI 10.1053/gast.2002.35379
    • Landers CJ, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 2002;123:689-699. (Pubitemid 34977074)
    • (2002) Gastroenterology , vol.123 , Issue.3 , pp. 689-699
    • Landers, C.J.1    Cohavy, O.2    Misra, R.3    Yang, H.4    Lin, Y.5    Braun, J.6    Targan, S.R.7
  • 17
    • 0345490989 scopus 로고    scopus 로고
    • Colonic Bacterial Superantigens Evoke an Inflammatory Response and Exaggerate Disease in Mice Recovering from Colitis
    • DOI 10.1053/j.gastro.2003.09.020
    • Lu J, Wang A, Ansari S, et al. Colonic bacterial superantigens evoke an inflammatory response and exaggerate disease in mice recovering from colitis. Gastroenterology. 2003;125:1785-1795. (Pubitemid 37500443)
    • (2003) Gastroenterology , vol.125 , Issue.6 , pp. 1785-1795
    • Lu, J.1    Wang, A.2    Ansari, S.3    Hershberg, R.M.4    McKay, D.M.5
  • 18
    • 0032536827 scopus 로고    scopus 로고
    • + T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type 1 response and ability to transfer disease
    • DOI 10.1084/jem.187.6.855
    • Cong Y, Brandwein SL, McCabe RP, et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med. 1998;187:855-864. (Pubitemid 28141659)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.6 , pp. 855-864
    • Cong, Y.1    Brandwein, S.L.2    McCabe, R.P.3    Lazenby, A.4    Birkenmeier, E.H.5    Sundberg, J.P.6    Elson, C.O.7
  • 19
    • 0029931508 scopus 로고    scopus 로고
    • Bacteria-specific T-Cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease
    • Duchmann R, Marker-Hermann E, Meyer zum Buschenfelde KH. Bacteria-specific T-cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease. Scand J Immunol. 1996;44:71-79. (Pubitemid 26227458)
    • (1996) Scandinavian Journal of Immunology , vol.44 , Issue.1 , pp. 71-79
    • Duchmann, R.1    Marker-Hermann, E.2    Meyer, Z.B.K.-H.3
  • 21
    • 3543093971 scopus 로고    scopus 로고
    • Mechanisms of natural tolerance in the intestine: Implications for inflammatory bowel disease
    • DOI 10.1097/00054725-200407000-00023
    • Jump RL, Levine AD. Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:462-478. (Pubitemid 39029194)
    • (2004) Inflammatory Bowel Diseases , vol.10 , Issue.4 , pp. 462-478
    • Jump, R.L.1    Levine, A.D.2
  • 22
    • 0037348386 scopus 로고    scopus 로고
    • Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs
    • DOI 10.1097/00054725-200303000-00002
    • Sydora BC, Tavernini MM, Wessler A, et al. Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs. Inflamm Bowel Dis. 2003;9: 87-97. (Pubitemid 36367317)
    • (2003) Inflammatory Bowel Diseases , vol.9 , Issue.2 , pp. 87-97
    • Sydora, B.C.1    Tavernini, M.M.2    Wessler, A.3    Jewell, L.D.4    Fedorak, R.N.5
  • 23
    • 77953274315 scopus 로고    scopus 로고
    • An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigens
    • Sydora BC, Macfarlane SM, Lupicki M, et al. An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigens. Clin Exp Immunol. 2010;161:187-196.
    • (2010) Clin Exp Immunol , vol.161 , pp. 187-196
    • Sydora, B.C.1    Macfarlane, S.M.2    Lupicki, M.3
  • 24
    • 17144383927 scopus 로고    scopus 로고
    • Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    • DOI 10.1053/j.gastro.2005.02.009
    • Kim SC, Tonkonogy SL, Albright CA, et al. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology. 2005;128:891-906. (Pubitemid 40523542)
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 891-906
    • Kim, S.C.1    Tonkonogy, S.L.2    Albright, C.A.3    Tsang, J.4    Balish, E.J.5    Braun, J.6    Huycke, M.M.7    Sartor, R.B.8
  • 25
    • 0036151001 scopus 로고    scopus 로고
    • Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-gamma and TNF-alpha production
    • DOI 10.1136/gut.0500170..
    • Waidmann M, Allemand Y, Lehmann J, et al. Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-gamma and TNF-alpha production. Gut. 2002;50:170-179. (Pubitemid 34087927)
    • (2002) Gut , vol.50 , Issue.2 , pp. 170-179
    • Waidmann, M.1    Allemand, Y.2    Lehmann, J.3    Di, G.S.4    Bucheler, N.5    Hamann, A.6    Autenrieth, I.B.7
  • 26
    • 0029791547 scopus 로고    scopus 로고
    • Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRalpha mutant mice with inflammatory bowel disease
    • Mizoguchi A, Mizoguchi E, Tonegawa S, et al. Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCR alpha mutant mice with inflammatory bowel disease. Int Immunol. 1996;8:1387-1394. (Pubitemid 26293888)
    • (1996) International Immunology , vol.8 , Issue.9 , pp. 1387-1394
    • Mizoguchi, A.1    Mizoguchi, E.2    Tonegawa, S.3    Bhan, A.K.4
  • 27
    • 0033083260 scopus 로고    scopus 로고
    • + T cells in TCR alpha-chain-deficient mice by gut-derived antigens
    • Takahashi I, Iijima H, Katashima R, et al. Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain-deficient mice by gut-derived antigens. J Immunol. 1999;162:1843-1850. (Pubitemid 29307066)
    • (1999) Journal of Immunology , vol.162 , Issue.3 , pp. 1843-1850
    • Takahashi, I.1    Iijima, H.2    Katashima, R.3    Itakura, M.4    Kiyono, H.5
  • 28
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol. 1998;161: 5733-5744. (Pubitemid 28519142)
    • (1998) Journal of Immunology , vol.161 , Issue.10 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 29
    • 33745245081 scopus 로고    scopus 로고
    • Bacterial antigens alone can influence intestinal barrier integrity, but live bacteria are required for initiation of intestinal inflammation and injury
    • Sydora BC, Martin SM, Lupicki M, et al. Bacterial antigens alone can influence intestinal barrier integrity, but live bacteria are required for initiation of intestinal inflammation and injury. Inflamm Bowel Dis. 2006;12:429-436.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 429-436
    • Sydora, B.C.1    Martin, S.M.2    Lupicki, M.3
  • 31
    • 0032962075 scopus 로고    scopus 로고
    • Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
    • DOI 10.1016/S0016-5085(99)70013-2
    • Madsen KL, Doyle JS, Jewell LD, et al. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology. 1999;116:1107-1114. (Pubitemid 29203020)
    • (1999) Gastroenterology , vol.116 , Issue.5 , pp. 1107-1114
    • Madsen, K.L.1    Doyle, J.S.2    Jewell, L.D.3    Tavernini, M.M.4    Fedorak, R.N.5
  • 32
    • 49049113111 scopus 로고    scopus 로고
    • Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice
    • Murdoch TB, Fu H, MacFarlane S, et al. Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice. Anal Chem. 2008;80:5524-5531.
    • (2008) Anal Chem , vol.80 , pp. 5524-5531
    • Murdoch, T.B.1    Fu, H.2    MacFarlane, S.3
  • 33
    • 18844405760 scopus 로고    scopus 로고
    • Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response
    • DOI 10.1007/s10620-005-2663-0
    • Sydora BC, Tavernini MM, Doyle JS, et al. Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response. Dig Dis Sci. 2005;50:905-913. (Pubitemid 40684910)
    • (2005) Digestive Diseases and Sciences , vol.50 , Issue.5 , pp. 905-913
    • Sydora, B.C.1    Tavernini, M.M.2    Doyle, J.S.G.3    Fedorak, R.N.4
  • 34
    • 33745271820 scopus 로고    scopus 로고
    • Enterobacter cloacae induce early onset chronic intestinal inflammation in germfree and SPF interleukin-10 gene-deficient mice
    • Sydora B, Lupicki M, Martin SM, et al. Enterobacter cloacae induce early onset chronic intestinal inflammation in germfree and SPF interleukin-10 gene-deficient mice. Can J Gastroenterol. 2006;20:67A.
    • (2006) Can J Gastroenterol , vol.20
    • Sydora, B.1    Lupicki, M.2    Martin, S.M.3
  • 35
    • 34247588114 scopus 로고    scopus 로고
    • Innate immunity of the newborn: Basic mechanisms and clinical correlates
    • DOI 10.1038/nri2075, PII NRI2075
    • Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol. 2007;7:379-390. (Pubitemid 46674489)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.5 , pp. 379-390
    • Levy, O.1
  • 38
    • 0032515016 scopus 로고    scopus 로고
    • Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking
    • Alferink J, Tafuri A, Vestweber D, et al. Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. Science. 1998;282: 1338-1341. (Pubitemid 28524500)
    • (1998) Science , vol.282 , Issue.5392 , pp. 1338-1341
    • Alferink, J.1    Tafuri, A.2    Vestweber, D.3    Hallmann, R.4    Hammerling, G.J.5    Arnold, B.6
  • 39
    • 0029155360 scopus 로고
    • Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
    • Shroff KE, Meslin K, Cebra JJ. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect Immun. 1995;63:3904-3913.
    • (1995) Infect Immun , vol.63 , pp. 3904-3913
    • Shroff, K.E.1    Meslin, K.2    Cebra, J.J.3
  • 40
    • 0035066374 scopus 로고    scopus 로고
    • Differential appearance of T cell subsets in the large and small intestine of neonatal mice
    • Kuo S, El Guindy A, Panwala CM, et al. Differential appearance of T cell subsets in the large and small intestine of neonatal mice. Pediatr Res. 2001;49:543-551. (Pubitemid 32274969)
    • (2001) Pediatric Research , vol.49 , Issue.4 I , pp. 543-551
    • Kuo, S.1    El, G.A.2    Panwala, C.M.3    Hagan, P.M.4    Camerini, V.5
  • 41
    • 63649143905 scopus 로고    scopus 로고
    • Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    • Schaub B, Liu J, Hoppler S, et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol. 2009;123:774-782.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 774-782
    • Schaub, B.1    Liu, J.2    Hoppler, S.3
  • 42
    • 30744443018 scopus 로고    scopus 로고
    • The immunological basis of the hygiene hypothesis
    • Allergy and Asthma in Modern Society: A Scientific Approach
    • Renz H, Blumer N, Virna S, et al. The immunological basis of the hygiene hypothesis. Chem Immunol Allergy. 2006;91:30-48. (Pubitemid 43097194)
    • (2006) Chemical Immunology and Allergy , vol.91 , pp. 30-48
    • Renz, H.1    Blumer, N.2    Virna, S.3    Sel, S.4    Garn, H.5
  • 43
    • 0028217167 scopus 로고
    • Inflammatory bowel disease and domestic hygiene in infancy
    • Gent AE, Hellier MD, Grace RH, et al. Inflammatory bowel disease and domestic hygiene in infancy. Lancet. 1994;343:766-767.
    • (1994) Lancet , vol.343 , pp. 766-767
    • Gent, A.E.1    Hellier, M.D.2    Grace, R.H.3
  • 44
    • 0032173243 scopus 로고    scopus 로고
    • Military history of patients with inflammatory bowel disease: An epidemiological study among U.S. veterans
    • DOI 10.1016/S0002-9270(98)00344-X, PII S000292709800344X
    • Delco F, Sonnenberg A. Military history of patients with inflammatory bowel disease: an epidemiological study among U. S. veterans. Am J Gastroenterol. 1998;93:1457-1462. (Pubitemid 29075182)
    • (1998) American Journal of Gastroenterology , vol.93 , Issue.9 , pp. 1457-1462
    • Delco, F.1    Sonnenberg, A.2
  • 45
    • 0029067109 scopus 로고
    • Perinatal and childhood risk factors for inflammatory bowel disease: A case-control study
    • Thompson NP, Pounder RE, Wakefield AJ. Perinatal and childhood risk factors for inflammatory bowel disease: a case-control study. Eur J Gastroenterol Hepatol. 1995;7:385-390.
    • (1995) Eur J Gastroenterol Hepatol , vol.7 , pp. 385-390
    • Thompson, N.P.1    Pounder, R.E.2    Wakefield, A.J.3
  • 47
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • DOI 10.1038/nature07008, PII NATURE07008
    • Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008;453:620-625. (Pubitemid 351769307)
    • (2008) Nature , vol.453 , Issue.7195 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 48
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105:16731-16736.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 50
    • 0035162229 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: Exploring the Third Way in immunology
    • DOI 10.1038/ni1101-997
    • Hayday A, Theodoridis E, Ramsburg E, et al. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat Immunol. 2001;2: 997-1003. (Pubitemid 33069493)
    • (2001) Nature Immunology , vol.2 , Issue.11 , pp. 997-1003
    • Hayday, A.1    Theodoridis, E.2    Ramsburg, E.3    Shires, J.4
  • 51
    • 77949349095 scopus 로고    scopus 로고
    • 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Induction and control of regulatory T cells in the gastrointestinal tract: consequences for local and peripheral immune responses
    • Belkaid Y, Liesenfeld O, Maizels RM. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: induction and control of regulatory T cells in the gastrointestinal tract: consequences for local and peripheral immune responses. Clin Exp Immunol. 160:35-41.
    • Clin Exp Immunol , vol.160 , pp. 35-41
    • Belkaid, Y.1    Liesenfeld, O.2    Maizels, R.M.3
  • 52
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.