Cationic chalcone antibiotics. Design, synthesis, and mechanism of action

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2667-2677

  Nielsen, Simon F ^a,c   Larsen, Mogens ^a,d   Boesen, Thomas ^a,b   Schønning, Kristian ^a   Kromann, Hasse ^a,b  

^a Lica Pharmaceuticals A/S   (Denmark)

^b MedChem Aps   (Denmark)

^c LEO PHARMA A S   (Denmark)

^d H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHALCONE; LICOCHALCONE A; LINEZOLID;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; HEMOLYSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; PROTON TRANSPORT; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; CATIONS; CHALCONES; COLONY COUNT, MICROBIAL; DRUG DESIGN; HEMOLYSIS; HUMANS; KINETICS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; QUATERNARY AMMONIUM COMPOUNDS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144427687     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049424k     Document Type: Article

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