Delayed intervention in experimental stroke with TRC051384 - A small molecule HSP70 inducer

Neuropharmacology

Volumn 60, Issue 6, 2011, Pages 991-999

  Mohanan, Anookh ^a   Deshpande, Shailesh ^a   Jamadarkhana, Prashant G ^a   Kumar, Prabhat ^a   Gupta, Ramesh C ^a   Chauthaiwale, Vijay ^b   Dutt, Chaitanya ^a  

^a Torrent Pharmaceuticals Ltd   (India)

^b DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Delayed intervention; Heat shock protein 70; Magnetic resonance imaging; Transient cerebral ischemia; TRC051384

Indexed keywords

1 [2 (MORPHOLIN 4 YL)ETHYL] 3 [4 [3 [6 (MORPHOLIN 4 YL)PYRIDIN 2 YL]PROP 2 ENOYL]PHENYL]UREA; ANTIINFLAMMATORY AGENT; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; TRC 051284; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; HUMAN; HUMAN CELL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; RAT; SURVIVAL RATE; THERAPY DELAY; TRANSIENT ISCHEMIC ATTACK; TREATMENT DURATION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN EDEMA; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SURVIVAL ANALYSIS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UREA;

EID: 79952442166     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.12.003     Document Type: Article

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