A short primer on the calcium sensing receptor: An important cog in the colon cancer wheel?

Digestive Diseases and Sciences

Volumn 56, Issue 2, 2011, Pages 279-284

  Ghevariya, Vishal ^a   Anand, Sury ^a  

^a BROOKLYN HOSPITAL CENTER   (United States)

Author keywords

Calcium; Chemoprevention; Colon cancer; Colonocytes

Indexed keywords

BETA CATENIN; CALCITRIOL; CALCIUM; CALCIUM SENSING RECEPTOR; T CELL FACTOR 4 PROTEIN; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; VITAMIN D; VITAMIN D RECEPTOR; WNT5A PROTEIN;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; CALCIUM ABSORPTION; CALCIUM INTAKE; CALCIUM SIGNALING; CANCER GROWTH; CELL CYCLE REGULATION; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CANCER; COMPLEX FORMATION; GASTROINTESTINAL TRACT; GENE SILENCING; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; VITAMIN D METABOLISM; VITAMIN INTAKE;

CALCIUM; CALCIUM SIGNALING; COLONIC NEOPLASMS; DNA PRIMERS; HUMANS; INTESTINAL MUCOSA; RECEPTORS, CALCIUM-SENSING;

EID: 79952439956     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1295-1     Document Type: Review

References (52)

1. Feldman M, Frideman LS, Brandt LJ. Minerals. In: Sleisenger and Fordtran's Gastrointestinal and Liver diseases. Vol 1. 8th ed. Saunders; 2006: 2177-2178.
2. Halstead CH, Levine MA, Lonnerdal BL et al. Vitamins and minerals. In: Textbook of Gastroenterology. Vol 1, 5th ed. Oxford: Blackwell; 2009:494-496.
3. EM Brown RJ MacLeod 2001 Extracellular calcium sensing and extracellular calcium signaling Physiol Rev 81 239 297 1:CAS:528:DC%2BD3MXitV2ktLo%3D 11152759 (Pubitemid 32096177)
4. Z Saidak R Mentaverri EM Brown 2009 The role of calcium sensing receptor in the development and progression of cancer Endocr Rev 30 2 178 195 1:CAS:528:DC%2BD1MXltVOrt7k%3D 10.1210/er.2008-0041 19237714
5. JF Whitfield 2009 Calcium, calcium-sensing receptor and colon cancer Cancer Lett 275 9 16 1:CAS:528:DC%2BD1MXhtVeiu70%3D 10.1016/j.canlet.2008.07.001 18725175
6. Whitfield JF, Bird RP, Chakravarthy B, Isaacs RJ et al. Calcium: Cell cycle regulator, differentiator, killer, chemopreventor, and maybe, tumor promoter. J Cell Biochem. 1995; (Suppl. 22):74-91.
7. Clevers H. Wnt/β-catenin signaling in development and disease. Cell. 2006; (127):469-480.
8. A Gregorieff D Pinto H Begthel, et al. 2005 Expression pattern of Wnt signaling components in the adult intestine Gastroenterology 129 626 638 1:CAS:528:DC%2BD2MXpvVWmtr4%3D 16083717 (Pubitemid 41096648)
9. D Pinto H Clevers 2007 Wnt control of stem cells and differentiation in the intestinal epithelium Exp Cell Res 306 357 363 10.1016/j.yexcr.2005.02.022
10. LK Su B Vogelstein KW Kinzler 1993 Association of the APC tumor suppressor proteins with catenins Science 262 1734 1737 1:CAS:528: DyaK2cXltFCmtw%3D%3D 10.1126/science.8259519 8259519 (Pubitemid 24030097)
11. I Nathke 2004 The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium Annu Rev Cell Dev Biol 20 337 366 10.1146/annurev.cellbio. 20.012103.094541 15473844 (Pubitemid 39488642)
12. JQ Tian A Quaroni 1999 Involvement of p21 (WAF/CIP1) and p27 (Kip1) in intestinal epithelial cell differentiation Am J Physiol 276 C1245 C1258 1:CAS:528:DyaK1MXktlSrtbo%3D 10362586
13. S Chakrabarty H Wang L Canaff, et al. 2005 Calcium sensing receptor in human colon carcinoma: interaction with Ca2+ and 1,25-Dihydroxyvitamin D3 Cancer Res 65 2 493 498 1:CAS:528:DC%2BD2MXns1Kqtg%3D%3D 15695391
14. 3 on the intracellular calcium gradient in mammalian colonic crypts Cancer Lett 127 43 53 1:CAS:528:DyaK1cXitlSlu70%3D 10.1016/S0304- 3835(98)00005-6 9619857 (Pubitemid 28230784)
15. S Chakrabarty V Radjendirane H Appelman, et al. 2003 Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of β-catenin-TCF activation Cancer Res 63 67 71 1:CAS:528:DC%2BD3sXjvFKmtQ%3D%3D 12517779 (Pubitemid 36070421)
16. W Birchmeier J Behrens 1994 Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness Biochim Biophys Acta 1198 11 26 1:CAS:528:DyaK2cXktlaisrs%3D 8199193 (Pubitemid 24159061)
17. W Birchmeier 1995 E-cadherin as a tumor (invasion) suppressor gene Bioessays 17 97 99 1:CAS:528:DyaK2MXltlems70%3D 10.1002/bies.950170203 7748170
18. H Oka H Shiozaki K Kobayashi, et al. 1993 Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis Cancer Res 53 1696 1701 1:CAS:528:DyaK3sXitlWgu7o%3D 8453644 (Pubitemid 23113254)
19. M Pignatelli TW Ansari P Gunter, et al. 1994 Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage J Pathol 174 243 248 1:STN:280:DyaK2M7ptVKrtw%3D%3D 10.1002/path.1711740403 7884585
20. N Bhagavathula EA Kelley M Reddy, et al. 2005 Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signaling in the regulation of growth and differentiation in colon carcinoma Br J Cancer 93 1364 1371 1:CAS:528:DC%2BD2MXht1yju7vK 10.1038/sj.bjc.6602852 16278666 (Pubitemid 41752863)
21. PJ Morin 1999 β-catenin signaling and cancer Bioessays 21 1021 1030 1:STN:280:DC%2BD3c%2FkslOiuw%3D%3D 10.1002/(SICI)1521-1878(199912)22:1<1021:: AID-BIES6>3.0.CO;2-P 10580987
22. F Fagotto N Funayama U Gluck, et al. 1996 Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus J Cell Biol 132 1105 1114 1:CAS:528:DyaK28XhvVSmu7Y%3D 10.1083/jcb.132.6.1105 8601588 (Pubitemid 26105498)
23. NA Wong M Pignatelli 2002 β-catenin-a linchpin in colorectal carcinogenesis? Am J Pathol 160 389 401 1:CAS:528:DC%2BD38XitVClu74%3D 11839557
24. 2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function Int J Cancer 121 1455 1462 10.1002/ijc.22858 (Pubitemid 47328703)
25. B Scaglione-Sewell C Abraham M Bissonnette, et al. 1998 Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells Cancer Res 58 1074 1081 1:CAS:528:DyaK1cXhsFersLc%3D 9500474 (Pubitemid 28182482)
26. JG Guillem CA O'Brian CJ Fitzer, et al. 1987 Studies on protein kinase C and colon carcinogenesis Arch Surg 122 1475 1478 1:CAS:528:DyaL1cXjtlCitw%3D%3D 3689124 (Pubitemid 18058303)
27. M Peterlink WB Grant HS Cross, et al. 2009 Calcium, vitamin D and cancer Anticancer Res 29 3687 3698
28. HS Cross M Pavelka J Slavik, et al. 1992 Growth control of human colon cancer cells by vitamin D and calcium in vitro J Natl Cancer Inst 84 1355 1357 1:CAS:528:DyaK3sXhs1KhtL8%3D 10.1093/jnci/84.17.1355 1495105
29. HS Cross W Hulla WM Tong, et al. 1995 Growth regulation of human colon adenocarcinoma-derived cells by calcium, vitamin D and epidermal growth factor J Nutr 125 2004S 2008S 1:CAS:528:DyaK2MXmvVynu7k%3D 7602383
30. W Hulla E Kallay W Krugluger, et al. 1995 Growth control of human colon-adenocarcinoma-derived Caco-2 cells by vitamin-D compounds and extracellular calcium in vitro: relation to c-myc oncogene and vitamin D receptor expression Int J Cancer 62 711 716 1:CAS:528:DyaK2MXpslWhu70%3D 10.1002/ijc.2910620611 7558419
31. WM Tong H Hofer A Ellinger, et al. 1999 Mechanism of antimitogenic action of vitamin D in human colon carcinoma cells: relevance for suppression of epidermal growth factor-stimulated cell growth Oncol Res 11 77 84 1:CAS:528:DyaK1MXmtFKmuro%3D 10489163
32. JGJ Hoenderop B Nilius RJM Bindels 2004 Calcium absorption across epithelia Physiol Rev 85 373 422 10.1152/physrev.00003.2004 (Pubitemid 40171261)
33. AG Renehan ST O'Dwyer NJ Haboubi, et al. 2002 Early events in colorectal carcinogenesis Colorectal Dis 4 76 89 10.1046/j.1463-1318.2002.00336.x 12780627 (Pubitemid 34413845)
34. K Aoki MM Taketo 2007 Adenomatous polyposis coli (APC): a multifunctional tumor suppressor gene J Cell Sci 120 3327 3335 1:CAS:528:DC%2BD2sXht1ygtbfJ 10.1242/jcs.03485 17881494 (Pubitemid 350028340)
35. T Senda A Shimomura A Iizuka-Kogo 2005 Adenomatosis polyposis coli (Apc) tumor suppressor gene as a multifunctional gene Anat Sci Int 80 121 131 1:CAS:528:DC%2BD2MXhtVGnsLbF 10.1111/j.1447-073x.2005.00106.x 16158975 (Pubitemid 41726023)
36. G Deng A Song E Pong, et al. 2004 Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor Cancer Res 64 2692 2698 1:CAS:528:DC%2BD2cXjtV2lt7s%3D 10.1158/0008-5472.CAN-03-3000 15087381 (Pubitemid 38500603)
37. KJ Smith KA Johnson TA Bryan, et al. 1993 The APC gene product in normal and tumor cells Proc Natl Acad Sci USA 90 2846 2850 1:CAS:528:DyaK3sXisFans7o%3D 10.1073/pnas.90.7.2846 8385345 (Pubitemid 23113514)
38. A Boquoi GH Enders 2008 Adenomatous polyposis coli mutations in colon cancer-slipping off the brake and onto the gas pedal Cancer Biol Ther 7 485 487 1:CAS:528:DC%2BD1cXhtVSktL7F 10.4161/cbt.7.4.5917 (Pubitemid 351847020)
39. M Huncharek J Muscat B Kupelnick 2009 Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26, 335 cases from 60 observational studies Nutr Cancer 61 47 69 1:CAS:528: DC%2BD1MXjt1Shsbc%3D 10.1080/01635580802395733 19116875
40. M Shabahang RR Buras F Davoodi, et al. 1993 1, 25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition Cancer Res 53 3712 3718 1:CAS:528:DyaK2cXlvVKm 8393379 (Pubitemid 23252030)
41. SR Evans J Nolla J Hanfelt, et al. 1998 Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer Clin Cancer Res 4 1591 1595 1:CAS:528:DyaK1cXks1Kitrk%3D 9676831 (Pubitemid 28304718)
42. B Vandewalle A Adenis L Hornez, et al. 1994 1, 25-Dihydroxyvitamin D3 receptors in normal and malignant human colorectal tissues Cancer Lett 86 67 73 1:CAS:528:DyaK2cXmvFyisb0%3D 10.1016/0304-3835(94)90181-3 7954357
43. L Canaff GN Hendy 2002 Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1, 25-Dihydroxyvitamin D J Biol Chem 277 30337 30350 1:CAS:528: DC%2BD38XmsVKht7w%3D 10.1074/jbc.M201804200 12036954
44. HG Palmer J Gonzalez-Sancho J Espada, et al. 2001 Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling J Cell Biol 154 369 3870 1:CAS:528:DC%2BD3MXlsVOjsLg%3D 10.1083/jcb.200102028 11470825 (Pubitemid 34286147)
45. HS Cross T Nittke M Peterlink 2009 Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention Anticancer Res 29 3705 3712 1:CAS:528:DC%2BD1MXhtVKku7fL 19667168
46. HA Bischoff-Ferrari E Giovannucci WC Willett, et al. 2006 Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes Am J Clin Nutr 84 18 28 1:CAS:528:DC%2BD28XntVertb8%3D 16825677 (Pubitemid 44699167)
47. K Bacsi E Hitre JP Kosa, et al. 2008 Effects of the lactase 13910C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population BMC Cancer 8 317 324 10.1186/1471-2407-8-317 18980667
48. M Jenab J McKay HB Bueno-de-Mesquita, et al. 2009 Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations Cancer Epidemiol Biomarkers Prev 18 9 2485 2491 1:CAS:528:DC%2BD1MXhtFWltLbF 10.1158/1055-9965.EPI-09-0319 19706842
49. II Pacheco RJ MacLeod 2008 CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia Am J Physiol Gastrointest Liver Physiol 295 748 759 10.1152/ajpgi.00560.2007
50. RJ MacLeod M Hayes I Pacheco 2007 Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells Am J Physiol Gastrintest Liver Physiol 293 403 411 10.1152/ajpgi.00119.2007 (Pubitemid 47105201)
51. EM Brown G Gamba D Riccardi, et al. 1993 Cloning and characterization of an extracellular Ca (2+)-sensing receptor from bovine parathyroid Nature 366 575 580 1:CAS:528:DyaK2cXhvVGmtLs%3D 10.1038/366575a0 8255296 (Pubitemid 24035999)
52. DM Harris VLW Go 2004 Vitamin D and colon carcinogenesis J Nutr 134 3463S 3471S 1:CAS:528:DC%2BD2cXhtVOmtLjN 15570055 (Pubitemid 39587591)