Adenomatous Polyposis Coli mutations in colon cancer - Slipping off the brake and onto the gas pedal

Cancer Biology and Therapy

Volumn 7, Issue 4, 2008, Pages 485-487

  Boquoi, A ^a   Enders, G H ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Adenomatous polyposis coli; Aneuploidy; Cancer initiation; Colon cancer; Cytokinesis; Genomic instability; Min mice; Mitotic spindle; Tetraploidy

Indexed keywords

AMINO ACID; APC PROTEIN; DNA; MUTANT PROTEIN; WNT PROTEIN;

ANAPHASE; ANEUPLOIDY; CANCER GROWTH; CELL CYCLE ARREST; CELL DIVISION; CELL INTERACTION; CELL KINETICS; CENTROSOME; CHROMOSOME SEGREGATION; COLON CANCER; COLON CARCINOGENESIS; COLON POLYPOSIS; CYTOKINESIS; DNA SYNTHESIS; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; POLYPLOIDY; PROMETAPHASE; PROTEIN EXPRESSION; SHORT SURVEY; TELOPHASE; TETRAPLOIDY;

EID: 45349108167     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.4.5917     Document Type: Short Survey

References (14)

1. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-9.
2. Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194:23-8
3. Duisberg P, Li R. Multistep Carcinogenesis: A Chain reaction of Aneuploidizations. Cell Cycle 2003; 2:202-10.
4. Caldwell CM, Green RA, Kaplan KB. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. The Journal of Cell Biology 2007; 7:1109-20.
5. Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF. Multiple intestinal neoplasia caused by mutations in the murine homolog of the APC gene. Science 1992; 256:668-70.
6. Green RA, Kaplan KB. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. The Journal of Cell Biology 2003; 163:949-61.
7. Aoki K, Taketo MM. Adenomatous poliposis coli (APC): a multi-functional tumor suppressor gene. Journal of Cell Science 2007; 120:3327-33.
8. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043-7.
9. Soravia C, Berk T, Madlensky L, Mitri A, Cheng H, Gallinger S, Cohen Z, Bapat B. Genotype-phenotype correlations in attenuated adenomatous polyposis coli. American Journal of Human Genetics 1998; 62:1290-301.
10. Rieder CL, Maiato H. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Developmental Cell 2004; 7:637-51.
11. Haigis KM, Caya JG, Reidelderfer M, Dove WF. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proceedings of the National Academy of Sciences 2002; 99:8927-31.
12. Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R. Chromosomal Instability in MYH- and APCMutant Adenomatous Polyps. Cancer Research 2006; 66:2514-19.
13. Lanni JS, Jacks T. Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption. Molecular and Cellular Biology 1998; 18: 1055-64.
14. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759-67.