메뉴 건너뛰기




Volumn 85, Issue 6, 2011, Pages 2918-2926

Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8∧E2C proteins and can also be achieved by an artificial repressor protein

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL REPRESSOR PROTEIN; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 79952382964     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01647-10     Document Type: Article
Times cited : (17)

References (47)
  • 1
    • 43949142801 scopus 로고    scopus 로고
    • Inhibition of transcription and DNA replication by the papillomavirus E8-E2C protein is mediated by interaction with corepressor molecules
    • DOI 10.1128/JVI.02647-07
    • Ammermann, I., M. Bruckner, F. Matthes, T. Iftner, and F. Stubenrauch. 2008. Inhibition of transcription and DNA replication by the papillomavirus E8-E2C protein is mediated by interaction with corepressor molecules. J. Virol. 82:5127-5136. (Pubitemid 351705221)
    • (2008) Journal of Virology , vol.82 , Issue.11 , pp. 5127-5136
    • Ammermann, I.1    Bruckner, M.2    Matthes, F.3    Iftner, T.4    Stubenrauch, F.5
  • 2
    • 27744600968 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis
    • Blachon, S., S. Bellanger, C. Demeret, and F. Thierry. 2005. Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis. J. Biol. Chem. 280:36088-36098.
    • (2005) J. Biol. Chem. , vol.280 , pp. 36088-36098
    • Blachon, S.1    Bellanger, S.2    Demeret, C.3    Thierry, F.4
  • 3
    • 40049085029 scopus 로고    scopus 로고
    • HPV and cervical cancer in the world 2007 report
    • Castellsague, X., et al. 2007. HPV and cervical cancer in the world 2007 report. Vaccine 25:C1-C26.
    • (2007) Vaccine , vol.25
    • Castellsague, X.1
  • 5
    • 0037448656 scopus 로고    scopus 로고
    • Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein
    • DOI 10.1038/sj.onc.1206108
    • Demeret, C., A. Garcia-Carranca, and F. Thierry. 2003. Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene 22:168-175. (Pubitemid 36174174)
    • (2003) Oncogene , vol.22 , Issue.2 , pp. 168-175
    • Demeret, C.1    Garcia-Carranca, A.2    Thierry, F.3
  • 6
    • 0031025688 scopus 로고    scopus 로고
    • Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
    • DOI 10.1093/emboj/16.3.504
    • Desaintes, C., C. Demeret, S. Goyat, M. Yaniv, and F. Thierry. 1997. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J. 16:504-514. (Pubitemid 27067780)
    • (1997) EMBO Journal , vol.16 , Issue.3 , pp. 504-514
    • Desaintes, C.1    Demeret, C.2    Goyat, S.3    Yaniv, M.4    Thierry, F.5
  • 7
    • 0033549842 scopus 로고    scopus 로고
    • Papillomavirus E2 induces p53-independent apoptosis in HeLa cells
    • DOI 10.1038/sj.onc.1202818
    • Desaintes, C., S. Goyat, S. Garbay, M. Yaniv, and F. Thierry. 1999. Papillomavirus E2 induces p53-independent apoptosis in HeLa cells. Oncogene 18:4538-4545. (Pubitemid 29405885)
    • (1999) Oncogene , vol.18 , Issue.32 , pp. 4538-4545
    • Desaintes, C.1    Goyat, S.2    Garbay, S.3    Yaniv, M.4    Thierry, F.5
  • 8
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P., et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92:9363-9367.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 9
    • 0025148460 scopus 로고
    • Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line
    • DOI 10.1016/0042-6822(90)90401-C
    • Doorbar, J., et al. 1990. Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line. Virology 178:254-262. (Pubitemid 20276690)
    • (1990) Virology , vol.178 , Issue.1 , pp. 254-262
    • Doorbar, J.1    Parton, A.2    Hartley, K.3    Banks, L.4    Crook, T.5    Stanley, M.6    Crawford, L.7
  • 10
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick, J. J., A. A. McBride, and P. M. Howley. 1995. Suppression of cellular proliferation by the papillomavirus E2 protein. J. Virol. 69:7791-7799.
    • (1995) J. Virol. , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 11
    • 77956037490 scopus 로고    scopus 로고
    • Interaction of the papillomavirus E8-E2C protein with the cellular CHD6 protein contributes to transcriptional repression
    • Fertey, J., et al. 2010. Interaction of the papillomavirus E8-E2C protein with the cellular CHD6 protein contributes to transcriptional repression. J. Virol. 84:9505-9515.
    • (2010) J. Virol. , vol.84 , pp. 9505-9515
    • Fertey, J.1
  • 13
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin, E. C., and D. DiMaio. 2000. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. U. S. A. 97:12513-12518.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 12513-12518
    • Goodwin, E.C.1    DiMaio, D.2
  • 14
    • 0031957756 scopus 로고    scopus 로고
    • Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
    • Goodwin, E. C., L. K. Naeger, D. E. Breiding, E. J. Androphy, and D. DiMaio. 1998. Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol. 72:3925-3934. (Pubitemid 28188694)
    • (1998) Journal of Virology , vol.72 , Issue.5 , pp. 3925-3934
    • Goodwin, E.C.1    Naeger, L.K.2    Breiding, D.E.3    Androphy, E.J.4    DiMaio, D.5
  • 15
    • 0034718610 scopus 로고    scopus 로고
    • Rapid induction of senescence in human cervical carcinoma cells
    • Goodwin, E. C., et al. 2000. Rapid induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 97:10978-10983.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10978-10983
    • Goodwin, E.C.1
  • 16
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall, A. H., and K. A. Alexander. 2003. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J. Virol. 77:6066-6069.
    • (2003) J. Virol. , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 17
    • 0030045822 scopus 로고    scopus 로고
    • Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene
    • Hwang, E. S., L. K. Naeger, and D. DiMaio. 1996. Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene 12:795-803. (Pubitemid 26072266)
    • (1996) Oncogene , vol.12 , Issue.4 , pp. 795-803
    • Hwang, E.-S.1    Naeger, L.K.2    DiMaio, D.3
  • 18
    • 0027158747 scopus 로고
    • Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
    • Hwang, E. S., et al. 1993. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J. Virol. 67:3720-3729.
    • (1993) J. Virol. , vol.67 , pp. 3720-3729
    • Hwang, E.S.1
  • 19
    • 59349090094 scopus 로고    scopus 로고
    • Papillomavirus DNA replication - From initiation to genomic instability
    • Kadaja, M., T. Silla, E. Ustav, and M. Ustav. 2009. Papillomavirus DNA replication - from initiation to genomic instability. Virology 384:360-368.
    • (2009) Virology , vol.384 , pp. 360-368
    • Kadaja, M.1    Silla, T.2    Ustav, E.3    Ustav, M.4
  • 20
    • 33748159277 scopus 로고    scopus 로고
    • Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes
    • DOI 10.1016/j.virol.2006.05.030, PII S0042682206003618
    • Karstensen, B., et al. 2006. Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes. Virology 353:200-209. (Pubitemid 44308492)
    • (2006) Virology , vol.353 , Issue.1 , pp. 200-209
    • Karstensen, B.1    Poppelreuther, S.2    Bonin, M.3    Walter, M.4    Iftner, T.5    Stubenrauch, F.6
  • 21
    • 55249105739 scopus 로고    scopus 로고
    • The E8-E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes
    • Lace, M. J., J. R. Anson, G. S. Thomas, L. P. Turek, and T. H. Haugen. 2008. The E8-E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes. J. Virol. 82:10841-10853.
    • (2008) J. Virol. , vol.82 , pp. 10841-10853
    • Lace, M.J.1    Anson, J.R.2    Thomas, G.S.3    Turek, L.P.4    Haugen, T.H.5
  • 22
    • 34648837230 scopus 로고    scopus 로고
    • Silencing of HPV 18 oncoproteins with RNA interference causes growth inhibition of cervical cancer cells
    • Lea, J. S., et al. 2007. Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells. Reprod. Sci. 14:20-28.
    • (2007) Reprod. Sci. , vol.14 , pp. 20-28
    • Lea, J.S.1
  • 23
    • 0033838255 scopus 로고    scopus 로고
    • Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
    • Lechner, M. S., G. E. Begg, D. W. Speicher, and F. J. Rauscher III. 2000. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell. Biol. 20:6449-6465.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6449-6465
    • Lechner, M.S.1    Begg, G.E.2    Speicher, D.W.3    Rauscher III, F.J.4
  • 24
    • 0035016463 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation
    • Lorenz, P., D. Koczan, and H. J. Thiesen. 2001. Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation. Biol. Chem. 382:637-644.
    • (2001) Biol. Chem. , vol.382 , pp. 637-644
    • Lorenz, P.1    Koczan, D.2    Thiesen, H.J.3
  • 25
    • 0028183182 scopus 로고
    • Kruppel-associated boxes are potent transcriptional repression domains
    • Margolin, J. F., et al. 1994. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Natl. Acad. Sci. U. S. A. 91:4509-4513.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4509-4513
    • Margolin, J.F.1
  • 26
    • 0025953354 scopus 로고
    • The papillomavirus E2 regulatory proteins
    • McBride, A. A., H. Romanczuk, and P. M. Howley. 1991. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266:18411-18414.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18411-18414
    • McBride, A.A.1    Romanczuk, H.2    Howley, P.M.3
  • 27
    • 0030855387 scopus 로고    scopus 로고
    • Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
    • Moosmann, P., O. Georgiev, H. J. Thiesen, M. Hagmann, and W. Schaffner. 1997. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. Biol. Chem. 378:669-677.
    • (1997) Biol. Chem. , vol.378 , pp. 669-677
    • Moosmann, P.1    Georgiev, O.2    Thiesen, H.J.3    Hagmann, M.4    Schaffner, W.5
  • 28
    • 0034026422 scopus 로고    scopus 로고
    • Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition
    • DOI 10.1128/JVI.74.8.3752-3760.2000
    • Nishimura, A., et al. 2000. Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J. Virol. 74:3752-3760. (Pubitemid 30180318)
    • (2000) Journal of Virology , vol.74 , Issue.8 , pp. 3752-3760
    • Nishimura, A.1    Ono, T.2    Ishimoto, A.3    Dowhanick, J.J.4    Frizzell, M.A.5    Howley, P.M.6    Sakai, H.7
  • 29
    • 0025329093 scopus 로고
    • Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts
    • Palermo-Dilts, D. A., T. R. Broker, and L. T. Chow. 1990. Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts. J. Virol. 64:3144-3149.
    • (1990) J. Virol. , vol.64 , pp. 3144-3149
    • Palermo-Dilts, D.A.1    Broker, T.R.2    Chow, L.T.3
  • 30
    • 33646201772 scopus 로고    scopus 로고
    • E2 proteins from high- And low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death
    • Parish, J. L., et al. 2006. E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death. J. Virol. 80:4580-4590.
    • (2006) J. Virol. , vol.80 , pp. 4580-4590
    • Parish, J.L.1
  • 31
    • 77950797365 scopus 로고    scopus 로고
    • NCoR1 mediates papillomavirus E8∧E2C transcriptional repression
    • Powell, M. L. C., et al. 2010. NCoR1 mediates papillomavirus E8∧E2C transcriptional repression. J. Virol. 84:4451-4460.
    • (2010) J. Virol. , vol.84 , pp. 4451-4460
    • Powell, M.L.C.1
  • 33
    • 0024357743 scopus 로고
    • Characterization of cDNAs of spliced HPV-11 E2 mRNA and other HPV mRNAs recovered via retrovirus-mediated gene transfer
    • Rotenberg, M. O., C. M. Chiang, M. L. Ho, T. R. Broker, and L. T. Chow. 1989. Characterization of cDNAs of spliced HPV-11 E2 mRNA and other HPV mRNAs recovered via retrovirus-mediated gene transfer. Virology 172:468-477.
    • (1989) Virology , vol.172 , pp. 468-477
    • Rotenberg, M.O.1    Chiang, C.M.2    Ho, M.L.3    Broker, T.R.4    Chow, L.T.5
  • 34
    • 0037089626 scopus 로고    scopus 로고
    • SETDB1: A novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    • Schultz, D. C., K. Ayyanathan, D. Negorev, G. G. Maul, and F. J. Rauscher III. 2002. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16:919-932.
    • (2002) Genes Dev. , vol.16 , pp. 919-932
    • Schultz, D.C.1    Ayyanathan, K.2    Negorev, D.3    Maul, G.G.4    Rauscher III, F.J.5
  • 35
    • 77649248469 scopus 로고    scopus 로고
    • Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression
    • Smith, J. A., et al. 2010. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc. Natl. Acad. Sci. U. S. A. 107:3752-3757.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 3752-3757
    • Smith, J.A.1
  • 36
    • 0026576820 scopus 로고
    • Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites
    • Snijders, P. J., et al. 1992. Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites. J. Virol. 66:3172-3178.
    • (1992) J. Virol. , vol.66 , pp. 3172-3178
    • Snijders, P.J.1
  • 37
    • 0033982569 scopus 로고    scopus 로고
    • The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes
    • Stubenrauch, F., M. Hummel, T. Iftner, and L. A. Laimins. 2000. The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes. J. Virol. 74:1178-1186.
    • (2000) J. Virol. , vol.74 , pp. 1178-1186
    • Stubenrauch, F.1    Hummel, M.2    Iftner, T.3    Laimins, L.A.4
  • 38
    • 35348831815 scopus 로고    scopus 로고
    • The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins
    • DOI 10.1002/ijc.22907
    • Stubenrauch, F., E. Straub, J. Fertey, and T. Iftner. 2007. The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins. Int. J. Cancer 121:2284-2292. (Pubitemid 47585611)
    • (2007) International Journal of Cancer , vol.121 , Issue.10 , pp. 2284-2292
    • Stubenrauch, F.1    Straub, E.2    Fertey, J.3    Iftner, T.4
  • 39
    • 0035043328 scopus 로고    scopus 로고
    • The E8 domain confers a novel long-distance transcriptional repression activity on the E8̂E2C protein of high-risk human papillomavirus type 31
    • DOI 10.1128/JVI.75.9.4139-4149.2001
    • Stubenrauch, F., T. Zobel, and T. Iftner. 2001. The E8 domain confers a novel long-distance transcriptional repression activity on the E8E2C protein of high-risk human papillomavirus type 31. J. Virol. 75:4139-4149. (Pubitemid 32410126)
    • (2001) Journal of Virology , vol.75 , Issue.9 , pp. 4139-4149
    • Stubenrauch, F.1    Zobel, T.2    Iftner, T.3
  • 40
    • 59549085974 scopus 로고    scopus 로고
    • Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma
    • Thierry, F. 2009. Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology 384:375-379.
    • (2009) Virology , vol.384 , pp. 375-379
    • Thierry, F.1
  • 41
    • 49949089516 scopus 로고    scopus 로고
    • Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins
    • Thierry, F., and C. Demeret. 2008. Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins. Cell Death Differ. 15:1356-1363.
    • (2008) Cell Death Differ , vol.15 , pp. 1356-1363
    • Thierry, F.1    Demeret, C.2
  • 43
    • 0034614650 scopus 로고    scopus 로고
    • The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
    • Webster, K., et al. 2000. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J. Biol. Chem. 275:87-94.
    • (2000) J. Biol. Chem. , vol.275 , pp. 87-94
    • Webster, K.1
  • 44
    • 0034331178 scopus 로고    scopus 로고
    • Papillomavirus E2 induces senescence in HPV-positive cells via pRB- And p21(CIP)-dependent pathways
    • Wells, S. I., et al. 2000. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J. 19:5762-5771.
    • (2000) EMBO J. , vol.19 , pp. 5762-5771
    • Wells, S.I.1
  • 45
    • 33748249631 scopus 로고    scopus 로고
    • Brd4 links chromatin targeting to HPV transcriptional silencing
    • Wu, S. Y., et al. 2006. Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev. 20:2383-2396.
    • (2006) Genes Dev. , vol.20 , pp. 2383-2396
    • Wu, S.Y.1
  • 46
    • 0242663917 scopus 로고    scopus 로고
    • The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins
    • Zobel, T., T. Iftner, and F. Stubenrauch. 2003. The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins. Mol. Cell. Biol. 23:8352-8362.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8352-8362
    • Zobel, T.1    Iftner, T.2    Stubenrauch, F.3
  • 47
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • zur Hausen, H. 2002. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer. 2:342-350.
    • (2002) Nat. Rev. Cancer. , vol.2 , pp. 342-350
    • Zur Hausen, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.