메뉴 건너뛰기




Volumn 121, Issue 10, 2007, Pages 2284-2292

The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins

Author keywords

E6; E7; E8 E2C; p53; Papillomavirus; Rb

Indexed keywords

GLYCOPROTEIN E2; ONCOPROTEIN; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; VIRUS E6 PROTEIN; VIRUS E7 PROTEIN; VIRUS E8 PROTEIN; VIRUS PROTEIN;

EID: 35348831815     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22907     Document Type: Article
Times cited : (21)

References (59)
  • 2
    • 2542550364 scopus 로고    scopus 로고
    • Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract
    • Wentzensen N, Vinokurova S, von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res 2004;64:3878-84.
    • (2004) Cancer Res , vol.64 , pp. 3878-3884
    • Wentzensen, N.1    Vinokurova, S.2    von Knebel Doeberitz, M.3
  • 4
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002;21:6041-8.
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 5
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall AH, Alexander KA. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J Virol 2003;77:6066-9.
    • (2003) J Virol , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 6
    • 0141730323 scopus 로고    scopus 로고
    • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    • Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F. siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene 2003;22:5938-45.
    • (2003) Oncogene , vol.22 , pp. 5938-5945
    • Butz, K.1    Ristriani, T.2    Hengstermann, A.3    Denk, C.4    Scheffner, M.5    Hoppe-Seyler, F.6
  • 7
    • 0026691230 scopus 로고
    • Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA
    • von Knebel Doeberitz M, Rittmuller C, zur Hausen H, Durst M. Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA. Int J Cancer 1992;51:831-4.
    • (1992) Int J Cancer , vol.51 , pp. 831-834
    • von Knebel Doeberitz, M.1    Rittmuller, C.2    zur Hausen, H.3    Durst, M.4
  • 9
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993;75:495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 10
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243:934-7.
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 11
    • 0026568793 scopus 로고
    • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product
    • Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 1992;89:4549-53.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4549-4553
    • Chellappan, S.1    Kraus, V.B.2    Kroger, B.3    Munger, K.4    Howley, P.M.5    Phelps, W.C.6    Nevins, J.R.7
  • 12
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 1996;56:4620-4.
    • (1996) Cancer Res , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 13
    • 0034899522 scopus 로고    scopus 로고
    • Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7
    • Gonzalez SL, Stremlau M, He X, Basile JR, Munger K. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J Virol 2001;75:7583-91.
    • (2001) J Virol , vol.75 , pp. 7583-7591
    • Gonzalez, S.L.1    Stremlau, M.2    He, X.3    Basile, J.R.4    Munger, K.5
  • 14
    • 0024573764 scopus 로고
    • Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms
    • Smotkin D, Prokoph H, Wettstein FO. Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J Virol 1989;63:1441-7.
    • (1989) J Virol , vol.63 , pp. 1441-1447
    • Smotkin, D.1    Prokoph, H.2    Wettstein, F.O.3
  • 15
    • 0024429348 scopus 로고
    • The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes
    • Bernard BA, Bailly C, Lenoir MC, Darmon M, Thierry F, Yaniv M. The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. J Virol 1989;63:4317-24.
    • (1989) J Virol , vol.63 , pp. 4317-4324
    • Bernard, B.A.1    Bailly, C.2    Lenoir, M.C.3    Darmon, M.4    Thierry, F.5    Yaniv, M.6
  • 16
    • 0025311444 scopus 로고
    • Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
    • Romanczuk H, Thierry F, Howley PM. Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J Virol 1990;64:2849-59.
    • (1990) J Virol , vol.64 , pp. 2849-2859
    • Romanczuk, H.1    Thierry, F.2    Howley, P.M.3
  • 17
    • 0026558934 scopus 로고
    • During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element
    • Tan SH, Gloss B, Bernard HU. During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element. Nucleic Acids Res 1992;20:251-6.
    • (1992) Nucleic Acids Res , vol.20 , pp. 251-256
    • Tan, S.H.1    Gloss, B.2    Bernard, H.U.3
  • 18
    • 0033982569 scopus 로고    scopus 로고
    • The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes
    • Stubenrauch F, Hummel M, Iftner T, Laimins LA. The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes. J Virol 2000;74:1178-86.
    • (2000) J Virol , vol.74 , pp. 1178-1186
    • Stubenrauch, F.1    Hummel, M.2    Iftner, T.3    Laimins, L.A.4
  • 19
    • 0023441712 scopus 로고
    • The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region
    • Thierry F, Yaniv M. The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J 1987;6:3391-7.
    • (1987) EMBO J , vol.6 , pp. 3391-3397
    • Thierry, F.1    Yaniv, M.2
  • 20
    • 0027158747 scopus 로고
    • Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
    • Hwang ES, Riese DJ, II, Settleman J, Nilson LA, Honig J, Flynn S, DiMaio D. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol 1993;67:3720-9.
    • (1993) J Virol , vol.67 , pp. 3720-3729
    • Hwang, E.S.1    Riese II, D.J.2    Settleman, J.3    Nilson, L.A.4    Honig, J.5    Flynn, S.6    DiMaio, D.7
  • 21
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick JJ, McBride AA, Howley PM. Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol 1995;69:7791-9.
    • (1995) J Virol , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 22
    • 0031025688 scopus 로고    scopus 로고
    • Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
    • Desaintes C, Demeret C, Goyat S, Yaniv M, Thierry F. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J 1997;16:504-14.
    • (1997) EMBO J , vol.16 , pp. 504-514
    • Desaintes, C.1    Demeret, C.2    Goyat, S.3    Yaniv, M.4    Thierry, F.5
  • 23
    • 0034331178 scopus 로고    scopus 로고
    • Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways
    • Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD, Howley PM. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J 2000;19:5762-71.
    • (2000) EMBO J , vol.19 , pp. 5762-5771
    • Wells, S.I.1    Francis, D.A.2    Karpova, A.Y.3    Dowhanick, J.J.4    Benson, J.D.5    Howley, P.M.6
  • 24
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin EC, DiMaio D. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci USA 2000;97:12513-8.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12513-12518
    • Goodwin, E.C.1    DiMaio, D.2
  • 25
    • 0032545160 scopus 로고    scopus 로고
    • Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: Implications for its DNA binding-site selection mechanism
    • Hegde RS, Androphy EJ. Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: implications for its DNA binding-site selection mechanism. J Mol Biol 1998;284:1479-89.
    • (1998) J Mol Biol , vol.284 , pp. 1479-1489
    • Hegde, R.S.1    Androphy, E.J.2
  • 26
    • 0030405803 scopus 로고    scopus 로고
    • Control of papillomavirus DNA replication and transcription
    • Desaintes C, Demeret C. Control of papillomavirus DNA replication and transcription. Semin Cancer Biol 1996;7:339-47.
    • (1996) Semin Cancer Biol , vol.7 , pp. 339-347
    • Desaintes, C.1    Demeret, C.2
  • 27
    • 2042468820 scopus 로고    scopus 로고
    • Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes
    • You J, Croyle JL, Nishimura A, Ozato K, Howley PM. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 2004;117:349-60.
    • (2004) Cell , vol.117 , pp. 349-360
    • You, J.1    Croyle, J.L.2    Nishimura, A.3    Ozato, K.4    Howley, P.M.5
  • 28
    • 0141891451 scopus 로고    scopus 로고
    • Initition of DNA replication: Lessons from viral initiator proteins
    • Stenlund A. Initition of DNA replication: lessons from viral initiator proteins. Nat Rev Mol Cell Biol 2003;10:777-85.
    • (2003) Nat Rev Mol Cell Biol , vol.10 , pp. 777-785
    • Stenlund, A.1
  • 29
    • 0031957756 scopus 로고    scopus 로고
    • Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
    • Goodwin EC, Naeger LK, Breiding DE, Androphy EJ, DiMaio D. Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J Virol 1998;72:3925-34.
    • (1998) J Virol , vol.72 , pp. 3925-3934
    • Goodwin, E.C.1    Naeger, L.K.2    Breiding, D.E.3    Androphy, E.J.4    DiMaio, D.5
  • 30
    • 0023643049 scopus 로고
    • A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator
    • Lambert PF, Spalholz BA, Howley PM. A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator. Cell 1987;50:69-78.
    • (1987) Cell , vol.50 , pp. 69-78
    • Lambert, P.F.1    Spalholz, B.A.2    Howley, P.M.3
  • 31
    • 0034026422 scopus 로고    scopus 로고
    • Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition
    • Nishimura A, Ono T, Ishimoto A, Dowhanick JJ, Frizzell MA, Howley PM, Sakai H. Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J Virol 2000;74:3752-60.
    • (2000) J Virol , vol.74 , pp. 3752-3760
    • Nishimura, A.1    Ono, T.2    Ishimoto, A.3    Dowhanick, J.J.4    Frizzell, M.A.5    Howley, P.M.6    Sakai, H.7
  • 33
    • 0024556457 scopus 로고
    • Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: Structural and functional analysis of new viral cDNAs
    • Choe J, Vaillancourt P, Stenlund A, Botchan M. Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs. J Virol 1989;63:1743-55.
    • (1989) J Virol , vol.63 , pp. 1743-1755
    • Choe, J.1    Vaillancourt, P.2    Stenlund, A.3    Botchan, M.4
  • 35
    • 0024407710 scopus 로고
    • Characterization of rare human papillomavirus type 11 mRNAs coding for regulatory and structural proteins, using the polymerase chain reaction
    • Rotenberg MO, Chow LT, Broker TR. Characterization of rare human papillomavirus type 11 mRNAs coding for regulatory and structural proteins, using the polymerase chain reaction. Virology 1989;172:489-97.
    • (1989) Virology , vol.172 , pp. 489-497
    • Rotenberg, M.O.1    Chow, L.T.2    Broker, T.R.3
  • 36
    • 0025329093 scopus 로고
    • Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts
    • Palermo-Dilts DA, Broker TR, Chow LT. Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts. J Virol 1990;64:3144-9.
    • (1990) J Virol , vol.64 , pp. 3144-3149
    • Palermo-Dilts, D.A.1    Broker, T.R.2    Chow, L.T.3
  • 37
    • 0042208274 scopus 로고    scopus 로고
    • Identification of the E9/E2C cDNA and functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus
    • Jeckel S, Loetzsch E, Huber E, Stubenrauch F, Iftner T. Identification of the E9/E2C cDNA and functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus. J Virol 2003;77:8736-44.
    • (2003) J Virol , vol.77 , pp. 8736-8744
    • Jeckel, S.1    Loetzsch, E.2    Huber, E.3    Stubenrauch, F.4    Iftner, T.5
  • 38
    • 0026576820 scopus 로고
    • Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites
    • Snijders PJ, van den Brule AJ, Schrijnemakers HF, Raaphorst PM, Meijer CJ, Walboomers JM. Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites. J Virol 1992;66:3172-8.
    • (1992) J Virol , vol.66 , pp. 3172-3178
    • Snijders, P.J.1    van den Brule, A.J.2    Schrijnemakers, H.F.3    Raaphorst, P.M.4    Meijer, C.J.5    Walboomers, J.M.6
  • 39
    • 0035043328 scopus 로고    scopus 로고
    • The E8 domain confers a novel long-distance transcriptional repression activity on the E8E2C protein of high-risk human papillomavirus type 31
    • Stubenrauch F, Zobel T, Iftner T. The E8 domain confers a novel long-distance transcriptional repression activity on the E8E2C protein of high-risk human papillomavirus type 31. J Virol 2001;75:4139-49.
    • (2001) J Virol , vol.75 , pp. 4139-4149
    • Stubenrauch, F.1    Zobel, T.2    Iftner, T.3
  • 40
    • 0242663917 scopus 로고    scopus 로고
    • The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins
    • Zobel T, Iftner T, Stubenrauch F. The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins. Mol Cell Biol 2003;23:8352-62.
    • (2003) Mol Cell Biol , vol.23 , pp. 8352-8362
    • Zobel, T.1    Iftner, T.2    Stubenrauch, F.3
  • 41
    • 0031687934 scopus 로고    scopus 로고
    • Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions
    • Stubenrauch F, Colbert AM, Laimins LA. Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions. J Virol 1998;72:8115-23.
    • (1998) J Virol , vol.72 , pp. 8115-8123
    • Stubenrauch, F.1    Colbert, A.M.2    Laimins, L.A.3
  • 42
    • 0026695145 scopus 로고
    • Mechanism of action of the papillomavirus E2 repressor: Repression in the absence of DNA binding
    • Barsoum J, Prakash SS, Han P, Androphy EJ. Mechanism of action of the papillomavirus E2 repressor: repression in the absence of DNA binding. J Virol 1992;66:3941-5.
    • (1992) J Virol , vol.66 , pp. 3941-3945
    • Barsoum, J.1    Prakash, S.S.2    Han, P.3    Androphy, E.J.4
  • 43
    • 33748159277 scopus 로고    scopus 로고
    • Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes
    • Karstensen B, Poppelreuther S, Bonin M, Walter M, Iftner T, Stubenrauch F. Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes. Virology 2006;353:200-9.
    • (2006) Virology , vol.353 , pp. 200-209
    • Karstensen, B.1    Poppelreuther, S.2    Bonin, M.3    Walter, M.4    Iftner, T.5    Stubenrauch, F.6
  • 44
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 45
    • 0342948594 scopus 로고    scopus 로고
    • Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells
    • Francis DA, Schmid SI, Howley PM. Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J Virol 2000;74:2679-86.
    • (2000) J Virol , vol.74 , pp. 2679-2686
    • Francis, D.A.1    Schmid, S.I.2    Howley, P.M.3
  • 46
    • 0037229178 scopus 로고    scopus 로고
    • Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells
    • DeFilippis RA, Goodwin EC, Wu L, DiMaio D. Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J Virol 2003;77:1551-63.
    • (2003) J Virol , vol.77 , pp. 1551-1563
    • DeFilippis, R.A.1    Goodwin, E.C.2    Wu, L.3    DiMaio, D.4
  • 47
    • 0022773680 scopus 로고
    • Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes
    • Schneider-Gadicke A, Schwarz E. Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J 1986;5:2285-92.
    • (1986) EMBO J , vol.5 , pp. 2285-2292
    • Schneider-Gadicke, A.1    Schwarz, E.2
  • 48
    • 2342478606 scopus 로고    scopus 로고
    • Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells
    • Psyrri A, DeFilippis RA, Edwards AP, Yates KE, Manuelidis L, DiMaio D. Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res 2004;64:3079-86.
    • (2004) Cancer Res , vol.64 , pp. 3079-3086
    • Psyrri, A.1    DeFilippis, R.A.2    Edwards, A.P.3    Yates, K.E.4    Manuelidis, L.5    DiMaio, D.6
  • 49
  • 50
    • 0031024614 scopus 로고    scopus 로고
    • Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein
    • Frattini MG, Hurst SD, Lim HB, Swaminathan S, Laimins LA. Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein. EMBO J 1997;16:318-31.
    • (1997) EMBO J , vol.16 , pp. 318-331
    • Frattini, M.G.1    Hurst, S.D.2    Lim, H.B.3    Swaminathan, S.4    Laimins, L.A.5
  • 51
    • 0034614650 scopus 로고    scopus 로고
    • The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
    • Webster K, Parish J, Pandya M, Stern PL, Clarke AR, Gaston K. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J Biol Chem 2000;275:87-94.
    • (2000) J Biol Chem , vol.275 , pp. 87-94
    • Webster, K.1    Parish, J.2    Pandya, M.3    Stern, P.L.4    Clarke, A.R.5    Gaston, K.6
  • 52
    • 27744600968 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of high risk human papillomavirus E2 proteins induces apoptosis
    • Blachon S, Bellanger S, Demeret C, Thierry F. Nucleo-cytoplasmic shuttling of high risk human papillomavirus E2 proteins induces apoptosis. J Biol Chem 2005;280:36088-98.
    • (2005) J Biol Chem , vol.280 , pp. 36088-36098
    • Blachon, S.1    Bellanger, S.2    Demeret, C.3    Thierry, F.4
  • 53
    • 0037448656 scopus 로고    scopus 로고
    • Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein
    • Demeret C, Garcia-Carranca A, Thierry F. Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene 2003;22:168-75.
    • (2003) Oncogene , vol.22 , pp. 168-175
    • Demeret, C.1    Garcia-Carranca, A.2    Thierry, F.3
  • 54
    • 0037302447 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA
    • Bechtold V, Beard P, Raj K. Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA. J Virol 2003;77:2021-8.
    • (2003) J Virol , vol.77 , pp. 2021-2028
    • Bechtold, V.1    Beard, P.2    Raj, K.3
  • 55
    • 0027221073 scopus 로고
    • Cooperative DNA binding of the bovine papillomavirus E2 transcriptional activator is antagonized by truncated E2 polypeptides
    • Monini P, Blitz IL, Cassai E. Cooperative DNA binding of the bovine papillomavirus E2 transcriptional activator is antagonized by truncated E2 polypeptides. J Virol 1993;67:5668-76.
    • (1993) J Virol , vol.67 , pp. 5668-5676
    • Monini, P.1    Blitz, I.L.2    Cassai, E.3
  • 56
    • 33646205576 scopus 로고    scopus 로고
    • Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function
    • Schweiger MR, You J, Howley PM. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol 2006;80:4276-85.
    • (2006) J Virol , vol.80 , pp. 4276-4285
    • Schweiger, M.R.1    You, J.2    Howley, P.M.3
  • 57
    • 0041806599 scopus 로고    scopus 로고
    • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
    • Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci USA 2003;100:8758-63.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8758-8763
    • Dey, A.1    Chitsaz, F.2    Abbasi, A.3    Misteli, T.4    Ozato, K.5
  • 58
    • 12344269394 scopus 로고    scopus 로고
    • The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4
    • Baxter MK, McPhillips MG, Ozato K, McBride AA. The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J Virol 2005;79:4806-18.
    • (2005) J Virol , vol.79 , pp. 4806-4818
    • Baxter, M.K.1    McPhillips, M.G.2    Ozato, K.3    McBride, A.A.4
  • 59
    • 33645220568 scopus 로고    scopus 로고
    • Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle
    • Ilves I, Maemets K, Silla T, Janikson K, Ustav M. Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle. J Virol 2006;80:3660-5.
    • (2006) J Virol , vol.80 , pp. 3660-3665
    • Ilves, I.1    Maemets, K.2    Silla, T.3    Janikson, K.4    Ustav, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.