Differential regulation of t and b lymphocytes by pd-1 and SOCS-1 signaling in hepatitis C virus-associated non-hodgkin's lymphoma

Immunological Investigations

Volumn 40, Issue 3, 2011, Pages 243-264

  Yao, Zhi Q ^a,b   Ni, Lei ^b,c   Zhang, Ying ^b   Ma, Cheng J ^b   Zhang, Chun L ^b   Dong, Zhi P ^b   Frazier, Ashley D ^b   Wu, Xiao Y ^b   Thayer, Penny ^a   Borthwick, Thomas ^a   Chen, Xin Y ^c   Moorman, Jonathan P ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b East Tennessee State University   (United States)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

B cells; HCV; immune dysregulation; lymphoma; PD 1; SOCS 1; T cells

Indexed keywords

PROGRAMMED DEATH 1 LIGAND 1; SUPPRESSOR OF CYTOKINE SIGNALING 1;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; NONHODGKIN LYMPHOMA; NONHUMAN; OUTCOME ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ADULT; AGED; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; B-LYMPHOCYTES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPACIVIRUS; HEPATITIS C; HUMANS; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES;

EID: 79952367912     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2010.534218     Document Type: Article

References (49)

1. Alexander, W. S. (2002). Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2(6): 410-416. (Pubitemid 37328748)
2. Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., Ahmed, R. (2006). Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077): 682-687. (Pubitemid 43237609)
3. Basse, G., Ribes, D., Kamar, N., Mehrenberger, M., Esposito, L., Guitard, J., Lavayssiere, L., Oksman, F., Durand, D. and Rostaing, L. (2005). Rituximab therapy for de novo mixed cryoglobulinemia in renal transplant patients. Transplantation 80(11): 1560-1564. (Pubitemid 43005866)
4. Boni, C., Fisicaro, P., Valdatta, C., Amadei, B., Di Vincenzo, P., Giuberti, T., Laccabue, D., Zerbini, A., Cavalli, A., Missale, G., Bertoletti, A., Ferrari, C. (2007). Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J. Virol. 81(8): 4215-4225. (Pubitemid 46586915)
5. Casato, M., Mecucci, C., Agnello, V., Fiorilli, M., Knight, G. B., Matteucci, C., Gao, L., Kay, J., 2002. Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia. Blood 99(6): 2259-2261. (Pubitemid 34525518)
6. Chang, K. M., Rehermann, B., McHutchison, J. G., Pasquinelli, C., Southwood, S., Sette, A., Chisari, F. V. (1997). Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J. Clin. Invest. 100(9): 2376-2385. (Pubitemid 27500163)
7. Curry, M. P., Golden-Mason, L., Doherty, D. G., Deignan, T., Norris, S., Duffy, M., Nolan, N., Hall, W., Hegarty, J. E., O'Farrelly, C. (2003). Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver. J. Hepatol. 38(5): 642-650. (Pubitemid 36560650)
8. D'Souza, M., Fontenot, A. P., Mack, D. G., Lozupone, C., Dillon, S., Meditz, A., Wilson, C. C., Connick, E., Palmer, B. E. (2007). Programmed death 1 expression on HIVspecific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J. Immunol. 179(3): 1979-1987.
9. Dolganiuc, A., Chang, S., Kodys, K., Mandrekar, P., Bakis, G., Cormier, M., Szabo, G. (2006). Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J. Immunol. 177(10): 6758-6768. (Pubitemid 44715040)
10. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Celis, E., Chen, L. (2002). Tumorassociated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat. Med. 8(8): 793-800.
11. Eisen-Vandervelde, A. L., Waggoner, S. N., Yao, Z. Q., Cale, E. M., Hahn, C. S., Hahn, Y. S. (2004a). Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation. J. Biol. Chem. 279(42): 43479-43486. (Pubitemid 39390647)
12. Eisen-Vandervelde, A. L., Yao, Z. Q., Hahn, Y. S. (2004b). The molecular basis of HCVmediated immune dysregulation. Clin. Immunol. 111(1): 16-21. (Pubitemid 38482077)
13. El-Serag, H. B., Anand, B., Richardson, P., Rabeneck, L. (2003). Association between hepatitis C infection and other infectious diseases: A case for targeted screening? Am. J. Gastroenterol. 98(1): 167-174. (Pubitemid 36135186)
14. Frazier, A.D., C.L. Zhang, L. Ni, C.J. Ma, Y. Zhang, X.Y.W. A.N. Atia, Z.Q. Yao, J.P. Moorman. 2010. Program death-1 pathway affects suppressor of cytokine signaling-1 expression in T cells during hepatitis c infection. Viral Immunology 23:487-495.
15. Golden-Mason, L., Klarquist, J., Wahed, A. S., Rosen, H. R. (2008). Cutting edge: Programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: Race-dependent differences. J. Immunol. 180(6): 3637-3641.
16. Golden-Mason, L., Palmer, B., Klarquist, J., Mengshol, J. A., Castelblanco, N., Rosen, H. R. (2007). Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J. Virol. 81(17): 9249-9258. (Pubitemid 47311467)
17. Hermine, O., Lefrere, F., Bronowicki, J. P., Mariette, X., Jondeau, K., Eclache- Saudreau, V., Delmas, B., Valensi, F., Cacoub, P., Brechot, C., Varet, B., Troussard, X. (2002). Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N. Engl. J. Med. 347(2): 89-94. (Pubitemid 34753478)
18. Ivanovski, M., Silvestri, F., Pozzato, G., Anand, S., Mazzaro, C., Burrone, O. R., Efremov, D. G. (1998). Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 91(7): 2433-2442. (Pubitemid 28155518)
19. Kassel, R., Cruise, M. W., Iezzoni, J. C., Taylor, N. A., Pruett, T. L. Hahn, Y. S. (2009). Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Hepatology 50(5): 1625-1637.
20. Khoury, S. J., Sayegh, M. H. (2004). The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 20(5): 529-538. (Pubitemid 38638123)
21. King, E., Trabue, C., Yin, D., Yao, Z. Q., Moorman, J. P. (2007). Hepatitis C. The complications of immune dysfunction. Expert Rev. Clin. Immunol. 3:145-157.
22. Kittlesen, D. J., Chianese-Bullock, K. A., Yao, Z. Q., Braciale, T. J., Hahn, Y. S. (2000). Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J. Clin. Invest. 106(10): 1239-1249.
23. Large, M. K., Kittlesen, D. J., Hahn, Y. S. (1999). Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence. J. Immunol. 162(2): 931-938. (Pubitemid 29035418)
24. Lechmann, M., Woitas, R. P., Langhans, B., Kaiser, R., Ihlenfeldt, H. G., Jung, G., Sauerbruch, T., Spengler, U. (1999). Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C. J. Hepatol. 31(6): 971-978.
25. Libra, M., Polesel, J., Russo, A. E., De Re, V., Cinà, D., Serraino, D., Nicoletti, F., Spandidos, D. A., Stivala, F., Talamini, R. 2010. Extrahepatic disorders of HCV infection: A distinct entity of B-cell neoplasia? Int. J. Oncol. 36(6):1331-1340.
26. Lucas, M., Vargas-Cuero, A. L., Lauer, G. M., Barnes, E., Willberg, C. B., Semmo, N., Walker, B. D., Phillips, R., Klenerman, P. (2004). Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells. J. Immunol. 172(3): 1744-1753. (Pubitemid 38116822)
27. Lukens, J. R., Cruise, M.W., Lassen, M. G. and Hahn, Y. S., 2008. Blockade of PD-1/B7- H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J. Immunol. 180(7): 4875-4884.
28. Machida, K., Cheng, K. T., Sung, V. M., Levine, A. M., Foung, S., Lai, M. M. (2006). Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J. Virol. 80(2): 866-874. (Pubitemid 43062898)
29. Manns, M. P., Rambusch, E. G. (1999). Autoimmunity and extrahepatic manifestations in hepatitis C virus infection. J. Hepatol. 31 Suppl: 139-142.
30. Mazzaro, C., Franzin, F., Tulissi, P., Pussini, E., Crovatto, M., Carniello, G. S., Efremov, D. G., Burrone, O., Santini, G., Pozzato, G. (1996). Regression of monoclonal Bcell expansion in patients affected by mixed cryoglobulinemia responsive to alphainterferon therapy. Cancer 77(12):2604-2613. (Pubitemid 126497594)
31. Moorman, J., Dong, Z. P., Ni, L., Zhang, C., Borthwick, T., Yao, Z. Q. (2009). Abnormal B-cell activation associated with TALL-1 over-expression and SOCS-1 suppression during chronic hepatitis C virus infection. Immunology 128(2): 227-235.
32. Nishimura, H., Honjo, T. (2001). PD-1: An inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22(5): 265-268. (Pubitemid 32667515)
33. Okazaki, T., Honjo, T. (2007). PD-1 and PD-1 ligands: From discovery to clinical application. Int. Immunol. 19(7): 813-824. (Pubitemid 47241890)
34. Quinn, E. R., Chan, C. H., Hadlock, K. G., Foung, S. K., Flint, M., Levy, S. (2001). The Bcell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. Blood 98(13): 3745-3749.
35. Racanelli, V., Sansonno, D., Piccoli, C., D'Amore, F. P., Tucci, F. A., Dammacco, F. (2001). Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patients. J. Immunol. 167(1): 21-29. (Pubitemid 32567756)
36. Rehermann, B., Chang, K. M., McHutchison, J. G., Kokka, R., Houghton, M., Chisari, F. V. (1996). Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J. Clin. Invest. 98(6): 1432-1440. (Pubitemid 26322069)
37. Saadoun, D., Rosenzwajg, M., Landau, D., Piette, J. C., Klatzmann, D., Cacoub, P. (2008). Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. Blood 111(11): 5334-5341.
38. Sansonno, D., Dammacco, F. (2005). Hepatitis C virus, cryoglobulinaemia, and vasculitis: Immune complex relations. Lancet Infect. Dis. 5(4): 227-236. (Pubitemid 40410068)
39. Sung, V. M., Shimodaira, S., Doughty, A. L., Picchio, G. R., Can, H., Yen, T. S., Lindsay, K. L., Levine, A. M., Lai, M. M. (2003). Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: The apoptotic effects of virus infection. J. Virol. 77(3): 2134-2146. (Pubitemid 36110026)
40. Tseng, C. T., Klimpel, G. R. (2002). Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J. Exp. Med. 195(1): 43-49. (Pubitemid 34074495)
41. Vogel, A.,Manns,M. P., Strassburg, C. P. (2002). Autoimmunity and viruses. Clin. Liver Dis. 6(3): 739-753.
42. Wedemeyer, H., He, X. S., Nascimbeni, M., Davis, A. R., Greenberg, H. B., Hoofnagle, J. H., Liang, T. J., Alter, H., Rehermann, B. (2002). Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J. Immunol. 169(6): 3447-3458. (Pubitemid 35013196)
43. Yao, Z. Q., Eisen-Vandervelde, A., Ray, S., Hahn, Y. S. (2003). HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1. Virology 314(1): 271-282. (Pubitemid 37153316)
44. Yao, Z. Q., Eisen-Vandervelde, A., Waggoner, S. N., Cale, E. M., Hahn, Y. S. (2004). Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J. Virol. 78(12): 6409-6419. (Pubitemid 38715939)
45. Yao, Z. Q., King, E., Prayther, D., Yin, D. and Moorman, J., 2007. T cell dysfunction by hepatitis C virus core protein involves PD-1/PDL-1 signaling. Viral Immunol 20(2): 276-87. (Pubitemid 47076209)
46. Yao, Z. Q., Nguyen, D. T., Hiotellis, A. I., Hahn, Y. S. (2001a). Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway. J. Immunol. 167(9): 5264-5272. (Pubitemid 33009764)
47. Yao, Z. Q., Prayther, D., Trabue, C., Dong, Z. P.,Moorman, J. (2008). Differential regulation of SOCS-1 signalling in B and T lymphocytes by hepatitis C virus core protein. Immunology.125: 197-207.
48. Yao, Z. Q., Ray, S., Eisen-Vandervelde, A., Waggoner, S., Hahn, Y. S. (2001b). Hepatitis C virus: Immunosuppression by complement regulatory pathway. Viral Immunol. 14(4): 277-295. (Pubitemid 34309058)
49. Zuckerman, E., Zuckerman, T., Sahar, D., Streichman, S., Attias, D., Sabo, E., Yeshurun, D., Rowe, J. M. (2001). The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection. Blood 97(6): 1555-1559. (Pubitemid 32217215)