Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K + channel without fall in plasma K+ concentration

American Journal of Physiology - Cell Physiology

Volumn 290, Issue 5, 2006, Pages

  Chen, Pei ^a   Guzman, John P ^a   Leong, Patrick K K ^a   Yang, Li E ^a   Perianayagam, Anjana ^a   Babilonia, Elisa ^b   Ho, Jennifer S ^a   Youn, Jang H ^a   Wen, Hui Wang ^b   McDonough, Alicia A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

cSrc; H + K+ ATPase; Na+ K+ ATPase; Potassium homeostasis; Protein tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; GLUCOSE; INSULIN; POTASSIUM; POTASSIUM CHANNEL; PROTEIN TYROSINE KINASE; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CANNULA; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; GLUCOSE TRANSPORT; IN VIVO STUDY; INFUSION RATE; INSULIN CLEARANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY; KIDNEY MEDULLA; MALE; MUSCLE; NONHUMAN; PHOSPHORYLATION; POTASSIUM EXCRETION; POTASSIUM RESTRICTION; POTASSIUM TRANSPORT; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; TAIL ARTERY; URINARY EXCRETION;

ANIMALS; INSULIN RESISTANCE; ION CHANNEL GATING; KIDNEY MEDULLA; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM, DIETARY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33646431148     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00501.2005     Document Type: Article

References (29)

1. Amlal H, Krane CM, Chen Q, and Soleimani M. Early polyuria and urinary concentrating defect in potassium deprivation. Am J Physiol Renal Physiol 279: F655-F663, 2000.
2. Ascherio A, Rimm EB, Hernán MA, Giovannucci EL, Kawachi I, Stampfer MJ, and Willett WC. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 98: 1198-1204, 1998.
3. Barri YM and Wingo CS. The effects of potassium depletion and supplementation on blood pressure: a clinical review. Am J Med Sci 314: 37-40, 1997.
4. Bia MJ and DeFronzo RA. Extrarenal potassium homeostasis. Am J Physiol Renal Fluid Electrolyte Physiol 240: F257-F268, 1981.
5. + content. Diabetes 51: 915-920, 2002.
6. + clamp. Am J Physiol Renal Physiol 280: F95-F102, 2001.
7. DeFronzo RA, Felig P, Ferrannini E, and Wahren J. Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol Endocrinol Metab 238: E421-E427, 1980.
8. Elkjær ML, Kwon TH, Wang W, Nielsen J, Knepper MA, Frøkiær J, and Nielsen S. Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats. Am J Physiol Renal Physiol 283: F1376-F1388, 2002.
9. Franse LV, Pahor M, Di Bari M, Somes GW, Cushman WC, and Applegate WB. Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension 35: 1025-1030, 2000.
10. Gallen IW, Rosa RM, Esparaz DY, Young JB, Robertson GL, Batlle D, Epstein FH, and Landsberg L. On the mechanism of the effects of potassium restriction on blood pressure and renal sodium retention. Am J Kidney Dis 31: 19-27, 1998.
11. Gennari FJ. Hypokalemia. N Engl J Med 339: 451-458, 1998.
12. Gennari FJ and Segal AS. Hyperkalemia: an adaptive response in chronic renal insufficiency. Kidney Int 62: 1-9, 2002.
13. Laroche-Joubert N and Doucet A. Collecting duct adaptation to potassium depletion. Semin Nephrol 19: 390-398, 1999.
14. Lin DH, Sterling H, Lerea KM, Welling P, Jin L, Giebisch G, and Wang WH. K depletion increases protein tyrosine kinase-mediated phosphorylation of ROMK. Am J Physiol Renal Physiol 283: F671-F677, 2002.
15. Lin DH, Sterling H, and Wang WH. The protein tyrosine kinase-dependent pathway mediates the effect of K intake on renal K secretion. Physiology 20: 140-146, 2005.
16. McDonough AA, Thompson CB, and Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol 282: F967-F974, 2002.
17. +]. Semin Nephrol 25: 335-342, 2005.
18. + deprivation in colonic H,K-ATPase-deficient mice. J Clin Invest 101: 536-542, 1998.
19. Mennitt PA, Frindt G, Silver RB, and Palmer LG. Potassium restriction downregulates ROMK expression in rat kidney. Am J Physiol Renal Physiol 278: F916-F924, 2000.
20. + excretion. Am J Physiol Regul Integr Comp Physiol 278: R1134-R1139, 2000.
21. Nielsen S, Frøkiær J, Marples D, Kwon TH, Agre P, and Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
22. Rabinowitz L. Homeostatic regulation of potassium excretion. J Hypertens 7: 433-442, 1989.
23. Rabinowitz L. Aldosterone and potassium homeostasis. Kidney Int 49: 1738-1742, 1996.
24. Rhee MS, Perianayagam A, Chen P, Youn JH, and McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol 287: C1229-C1237, 2004.
25. +-ATPases: regulation and role in pathophysiological states. Am J Physiol Renal Physiol 276: F799-F811, 1999.
26. + pumps and cell cations. Am J Physiol Cell Physiol 276: C1411-C1419, 1999.
27. Thompson CB and McDonough AA. Skeletal muscle Na,K-ATPase α and β subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem 271: 32653-32658, 1996.
28. Wei Y, Bloom P, Lin D, Gu R, and Wang WH. Effect of dietary K intake on apical small-conductance K channel in CCD: role of protein tyrosine kinase. Am J Physiol Renal Physiol 281: F206-F212, 2001.
29. Yang LE, Zhong H, Leong PKK, Perianayagam A, Campese VM, and McDonough AA. Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Am J Physiol Renal Physiol 284: F1056-F1065, 2003.