Correlation of carotid artery atherosclerotic lesion echogenicity and severity at standard US with intraplaque neovascularization detected at contrast-enhanced US

Radiology

Volumn 258, Issue 2, 2011, Pages 618-626

  Staub, Daniel ^a,b   Partovi, Sasan ^b   Schinkel, Arend F L ^b   Coll, Blai ^a   Uthoff, Heiko ^b   Aschwanden, Markus ^b   Jaeger, Kurt A ^b   Feinstein, Steven B ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PERFLUTREN;

ADULT; AGED; ARTICLE; CAROTID ARTERY OBSTRUCTION; CAROTID ATHEROSCLEROSIS; CAROTID ATHEROSCLEROTIC PLAQUE NEOVASCULARIZATION; CONTRAST ENHANCEMENT; DISEASE SEVERITY; ECHOGRAPHY; FEMALE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; RISK ASSESSMENT; THICKNESS;

ADULT; AGED; AGED, 80 AND OVER; ALBUMINS; ANALYSIS OF VARIANCE; ATHEROSCLEROSIS; CAROTID STENOSIS; CHI-SQUARE DISTRIBUTION; CONTRAST MEDIA; FEMALE; FLUOROCARBONS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 79952350535     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.10101008     Document Type: Article

References (45)

1. Hobson RW 2nd, Mackey WC, Ascher E, et al. Management of atherosclerotic carotid artery disease: clinical practice guidelines of the Society for Vascular Surgery. J Vasc Surg 2008;48(2)480-486. (Pubitemid 351997463)
2. Nighoghossian N, Derex L, Douek P. The vulnerable carotid artery plaque: current imaging methods and new perspectives. Stroke 2005;36(12)2764-2772.
3. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1991;325(7)445-453.
4. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351(9113):1379-1387.
5. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273(18)1421-1428.
6. Halliday A, Mansfield A, Marro J, et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004;363 (9420)1491-1502.
7. Nordestgaard BG, Grønholdt ML, Sillesen H. Echolucent rupture-prone plaques. Curr Opin Lipidol 2003;14(5)505-512. (Pubitemid 37297306)
8. Grønholdt ML, Nordestgaard BG, Schroeder TV, Vorstrup S, Sillesen H. Ultrasonic echolucent carotid plaques predict future strokes. Circulation 2001;104(1)68-73. (Pubitemid 32623291)
9. Mathiesen EB, Bønaa KH, Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the tromsø study. Circulation 2001;103(17)2171-2175. (Pubitemid 32458326)
10. Polak JF, Shemanski L, O'Leary DH, et al. Hypoechoic plaque at US of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular Health Study. Radiology 1998;208(3)649-654. (Pubitemid 28405098)
11. Reiter M, Effenberger I, Sabeti S, et al. Increasing carotid plaque echolucency is predictive of cardiovascular events in high-risk patients. Radiology 2008;248(3)1050-1055.
12. Seo Y, Watanabe S, Ishizu T, et al. Echolucent carotid plaques as a feature in patients with acute coronary syndrome. Circ J 2006;70(12):1629-1634. (Pubitemid 44819882)
13. Honda O, Sugiyama S, Kugiyama K, et al. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J Am Coll Cardiol 2004;43(7):1177-1184. (Pubitemid 38452593)
14. Moreno PR, Purushothaman KR, Sirol M, Levy AP, Fuster V. Neovascularization in human atherosclerosis. Circulation 2006;113(18):2245-2252.
15. Fleiner M, Kummer M, Mirlacher M, et al. Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation 2004;110(18)2843-2850. (Pubitemid 39473607)
16. Sluimer JC, Daemen MJ. Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol 2009;218(1)7-29.
17. Feinstein SB. Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization. J Am Coll Cardiol 2006;48(2)236-243.
18. Feinstein SB, Coll B, Staub D, et al. Contrast enhanced ultrasound imaging. J Nucl Cardiol 2010;17(1)106-115.
19. Feinstein SB. The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. Am J Physiol Heart Circ Physiol 2004;287(2)H450-H457. (Pubitemid 38955272)
20. Shah F, Balan P, Weinberg M, et al. Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis? Vasc Med 2007;12(4)291-297.
21. Coli S, Magnoni M, Sangiorgi G, et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J Am Coll Cardiol 2008;52(3)223-230. (Pubitemid 351915779)
22. Xiong L, Deng YB, Zhu Y, Liu YN, Bi XJ. Correlation of carotid plaque neovascularization detected by using contrast-enhanced US with clinical symptoms. Radiology 2009;251(2)583-589.
23. Giannoni MF, Vicenzini E, Citone MC, et al. Contrast carotid ultrasound for the detection of unstable plaques with neoangiogenesis: a pilot study. Eur J Vasc Endovasc Surg 2009;37(6)722-727.
24. Staub D, Patel MB, Tibrewala A, et al. Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events. Stroke 2010;41(1)41-47.
25. Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis 2004;18(4)346-349. (Pubitemid 39664263)
26. Grant EG, Benson CB, Moneta GL, et al. Carotid artery stenosis: gray-scale and Doppler US diagnosis - Society of Radiologists in Ultrasound Consensus Conference. Radiology 2003;229(2)340-346. (Pubitemid 37310815)
27. Arnold JA, Modaresi KB, Thomas N, Taylor PR, Padayachee TS. Carotid plaque characterization by duplex scanning: observer error may undermine current clinical trials. Stroke 1999;30(1)61-65. (Pubitemid 29029442)
28. Doyle B, Caplice N. Plaque neovascularization and antiangiogenic therapy for atherosclerosis. J Am Coll Cardiol 2007;49(21)2073-2080. (Pubitemid 46771052)
29. Grønholdt ML. Ultrasound and lipoproteins as predictors of lipid-rich, rupture-prone plaques in the carotid artery. Arterioscler Thromb Vasc Biol 1999;19(1)2-13.
30. Grønholdt ML, Nordestgaard BG, Bentzon J, et al. Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. J Vasc Surg 2002;35(1)137-145. (Pubitemid 44725782)
31. Sluimer JC, Gasc JM, van Wanroij JL, et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 2008;51(13)1258- 1265.
32. Moreno PR, Purushothaman KR, Fuster V, et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 2004;110(14)2032-2038.
33. de Boer OJ, van der Wal AC, Teeling P, Becker AE. Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization? Cardiovasc Res 1999;41(2)443-449.
34. Naghavi M, Falk E, Hecht HS, et al. From vulnerable plaque to vulnerable patient. III. Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol 2006;98(2A)2H-15H.
35. Virmani R, Ladich ER, Burke AP, Kolodgie FD. Histopathology of carotid atherosclerotic disease. Neurosurgery 2006;59(5 suppl 3):S219-S227.
36. Owen DR, Shalhoub J, Miller S, et al. Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US. Radiology 2010;255(2)638-644.
37. Graebe M, Pedersen SF, Højgaard L, Kjaer A, Sillesen H. 18FDG PET and ultrasound echolucency in carotid artery plaques. JACC Cardiovasc Imaging 2010;3(3)289-295.
38. Watanabe K, Sugiyama S, Kugiyama K, et al. Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease. J Am Coll Cardiol 2005;46(11):2022-2030.
39. Jeziorska M, Woolley DE. Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development. Hum Pathol 1999;30(8)919-925.
40. Koutouzis M, Nomikos A, Nikolidakis S, et al. Statin treated patients have reduced intraplaque angiogenesis in carotid endarterectomy specimens. Atherosclerosis 2007;192(2)457-463.
41. Hirano M, Nakamura T, Kitta Y, et al. Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome. Atherosclerosis 2009;203(2)483-488.
42. Nakamura T, Obata JE, Kitta Y, et al. Rapid stabilization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome. J Cardiovasc Pharmacol 2008;51(4)365-371.
43. Shalhoub J, Owen DR, Gauthier T, Monaco C, Leen EL, Davies AH. The use of contrast enhanced ultrasound in carotid arterial disease. Eur J Vasc Endovasc Surg 2010;39(4)381-387.
44. Momjian I, Momjian S, Albanese S, Comelli M, Lovblad K, Sztajzel R. Visual analysis or semi-automated gray-scale-based color mapping of the carotid plaque: which method correlates the best with the presence of cerebrovascular symptoms and/or lesions on MRI? J Neuroimaging 2009;19(2)119-126.
45. Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004;44(12)2293-2300.