18FDG PET and Ultrasound Echolucency in Carotid Artery Plaques

JACC: Cardiovascular Imaging

Volumn 3, Issue 3, 2010, Pages 289-295

  Græbe, Martin ^a   Pedersen, Sune F ^b   Højgaard, Liselotte ^b   Kjær, Andreas ^b   Sillesen, Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

atherosclerosis; carotid plaque; echolucent; FDG; PET; ultrasound

Indexed keywords

CD68 ANTIGEN; FLUORODEOXYGLUCOSE F 18; CD68 ANTIGEN, HUMAN; DIAGNOSTIC AGENT; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MESSENGER RNA; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; ECHOCARDIOGRAPHY; FEMALE; GENE EXPRESSION; HUMAN; IMAGE ANALYSIS; INTERMETHOD COMPARISON; MACROPHAGE; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RATING SCALE; RISK ASSESSMENT; DOPPLER FLOWMETRY; ECHOGRAPHY; GENETICS; HOSPITALIZATION; IMMUNOLOGY; INFLAMMATION; MIDDLE AGED; PREDICTION AND FORECASTING; PROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCINTISCANNING;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CAROTID STENOSIS; CEREBROVASCULAR DISORDERS; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; ULTRASONOGRAPHY, DOPPLER;

EID: 77649261262     PISSN: 1936878X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcmg.2010.01.001     Document Type: Article

References (21)

1. Rothwell P.M., Eliasziw M., Gutnikov S.A., Warlow C.P., and Barnett H.J. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363 (2004) 915-924
2. Nicolaides A.N., Kakkos S.K., Griffin M., et al. Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study. Eur J Vasc Endovasc Surg 30 (2005) 275-284
3. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351 (1998) 1379-1387
4. Sabetai M.M., Tegos T.J., Nicolaides A.N., Dhanjil S., Pare G.J., and Stevens J.M. Reproducibility of computer-quantified carotid plaque echogenicity: can we overcome the subjectivity?. Stroke 31 (2000) 2189-2196
5. Fosse E., Johnsen S.H., Stensland-Bugge E., et al. Repeated visual and computer-assisted carotid plaque characterization in a longitudinal population-based ultrasound study: the Tromso study. Ultrasound Med Biol 32 (2006) 3-11
6. Mathiesen E.B., Bonaa K.H., and Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the tromsø study. Circulation 103 (2001) 2171-2175
7. Gronholdt M.L., Nordestgaard B.G., Bentzon J., et al. Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. J Vasc Surg 35 (2002) 137-145
8. Gronholdt M.L., Nordestgaard B.G., Schroeder T.V., Vorstrup S., and Sillesen H. Ultrasonic echolucent carotid plaques predict future strokes. Circulation 104 (2001) 68-73
9. Basu S., Zhuang H., Torigian D.A., Rosenbaum J., Chen W., and Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med 39 (2009) 124-145
10. Warburton L., and Gillard J. Functional imaging of carotid atheromatous plaques. J Neuroimaging 16 (2006) 293-301
11. Vallabhajosula S., and Fuster V. Atherosclerosis: imaging techniques and the evolving role of nuclear medicine. J Nucl Med 38 (1997) 1788-1796
12. Rudd J.H.F., Warburton E.A., Fryer T.D., et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105 (2002) 2708-2711
13. Graebe M., Pedersen S.F., Borgwardt L., Højgaard L., Sillesen H., and Kjær A. Molecular pathology in vulnerable carotid plaques: correlation with [18]-fluorodeoxyglucose positron emission tomography (FDG PET). Eur J Vasc Endovasc Surg 37 (2009) 714-721
14. Tawakol A., Migrino R.Q., Bashian G.G., et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 48 (2006) 1818-1824
15. Grant E.G., Benson C.B., Moneta G.L., et al. Carotid artery stenosis: gray-scale and Doppler US diagnosis-Society of Radiologists in Ultrasound Consensus Conference. Radiology 229 (2003) 340-346
16. Font M.A., Fernandez A., Carvajal A., et al. Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET. Front Biosci 14 (2009) 3352-3360
17. Nicolaides A.N., Kakkos S.K., Griffin M., et al. Effect of image normalization on carotid plaque classification and the risk of ipsilateral hemispheric ischemic events: results from the asymptomatic carotid stenosis and risk of stroke study. Vascular 13 (2005) 211-221
18. AbuRahma A.F., Kyer III P.D., Robinson P.A., and Hannay R.S. The correlation of ultrasonic carotid plaque morphology and carotid plaque hemorrhage: clinical implications. Surgery 124 (1998) 721-726 discussion 726-8
19. Gronholdt M.L., Wiebe B.M., Laursen H., Nielsen T.G., Schroeder T.V., and Sillesen H. Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage. Eur J Vasc Endovasc Surg 14 (1997) 439-445
20. Carotid artery plaque composition-relationship to clinical presentation and ultrasound B-mode imaging. European Carotid Plaque Study Group. Eur J Vasc Endovasc Surg 10 (1995) 23-30
21. Russell D.A., Wijeyaratne S.M., and Gough M.J. Changes in carotid plaque echomorphology with time since a neurologic event. J Vasc Surg 45 (2007) 367-372