Echolucent rupture-prone plaques

Current Opinion in Lipidology

Volumn 14, Issue 5, 2003, Pages 505-512

  Nordestgaard, Børge G ^a   Grønholdt, Marie Louise M ^a   Sillesen, Henrik ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Arteriosclerosis; Coronary disease; Lipoproteins; Stroke; Ultrasound

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PRAVASTATIN; TRIACYLGLYCEROL;

ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CORONARY RISK; CORONARY STENT; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; ENDARTERECTOMY; HEART INFARCTION; HISTOPATHOLOGY; HUMAN; INTRAVASCULAR ULTRASOUND; LIPID COMPOSITION; PRIORITY JOURNAL; RESTENOSIS; REVIEW; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ARTERIOSCLEROSIS; CAROTID STENOSIS; HUMANS; LIPOPROTEINS; MACROPHAGES; MYOCARDIAL INFARCTION; RISK FACTORS;

EID: 0142061591     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200310000-00012     Document Type: Review

References (22)

1. Grønholdt ML. B-mode ultrasound and spiral CT for the assessment of carotid atherosclerosis. Neuroimag Clin N Am 2002; 12:421-435. This is a comprehensive review on the most recent developments in the field of B-mode ultrasound and spiral computed tomography.
2. Falk E. Why do plaques rupture? Circulation 1992; 86:III30-III42.
3. Denzel C, Fellner F, Wutke R, et al. Ultrasonographic analysis of arteriosclerotic plaques in the internal carotid artery. Eur J Ultrasound 2003; 16:161-167.
4. Grønholdt ML, Nordestgaard BG, Wiebe BM, et al. Echo-lucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content. Circulation 1998; 97:34-40.
5. Grønholdt ML, Nordestgaard BG, Bentzon J, et al. Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. J Vasc Surg 2002; 35:137-145. This is the first paper to demonstrate increased macrophage density in echolucent versus echo-rich carotid plaques. Increased macrophage density was also associated with increased plaque lipid content and elevated levels of plasma and LDL cholesterol. Finally, aspirin use was associated with reduced macrophage density.
6. Yuan C, Miller ZE, Cai J, Hatsukami T. Carotid atherosclerosis wall imaging by MRI. Neuroimag Clin N Am 2002; 12:391-401. A comprehensive review on the newest developments in the field of magnetic resonance imaging is presented.
7. Kofoed SC, Grønholdt ML, Wilhjelm JE, et al. Real-time spatial compound imaging improves reproducibility in the evaluation of atherosclerotic carotid plaques. Ultrasound Med Biol 2001; 27:1311-1317.
8. Wijeyaratne SM, Jarvis S, Stead LA, et al. A new method for characterizing carotid plaque: multiple cross-sectional view echomorphology. J Vasc Surg 2003; 37:778-784.
9. Mathiesen EB, Bønaa KH, Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: The Tromsø Study. Circulation 2001; 103:2171-2175.
10. Grønholdt ML, Nordestgaard BG, Schroeder T, et al. Ultrasonic echolucent carotid plaques predict future strokes. Circulation 2001; 104:68-73.
11. Liapis CD, Kakisis JD, Dimitroulis DA, Kostakis AG. The impact of the carotid plaque type on restenosis and future cardiovascular events: a 12-year prospective study. Eur J Vasc Endovasc Surg 2002; 24:239-244. This paper demonstrates that echolucency of the removed carotid plaque is associated with restenosis after endarterectomy, and with risk for myocardial infarction and stroke combined.
12. Schmidt C, Fagerberg B, Wikstrand J, et al. Multiple risk factor intervention reduces cardiovascular risk in hypertensive patients with echolucent plaques in the carotid artery. J Intern Med 2003; 253:430-438. The paper demonstrates in a post-hoc analysis, and, for the first time, that benefit from a multiple risk factor intervention programme is confined to those patients with echolucent carotid plaques. No benefit was observed in patients with echo-rich plaques or in patients without carotid plaques. These data should, however, be confirmed in a large-scale trial.
13. Pedro LM, Fernandes JF, Pedro MM, et al. Ultrasonographic risk score of carotid plaques. Eur J Vasc Endovasc Surg 2002; 24:492-498.
14. Clinton SK, Libby P. Cytokines and growth factors in atherogenesis. Arch Pathol Lab Med 1992; 116:1292-1300.
15. Kofoed SC, Grønholdt ML, Bismuth J, et al. Echolucent, rupture-prone carotid plaques associated with elevated triglyceride-rich lipoproteins, particularly in women. J Vasc Surg 2002; 36:783-792. Fasting and postprandial triglyceride-rich lipoproteins (but not LDLs) were elevated in patients with carotid artery stenosis of 50% or more as compared with control individuals, and in particular identified echolucent, rupture-prone carotid plaques. These observations were more pronounced in women than in men.
16. Mathiesen EB, Bonaa KH, Joakimsen O. Low levels of high-density lipoprotein cholesterol are associated with echolucent carotid artery plaques: The Tromso Study. Stroke 2001; 32:1960-1965.
17. Zureik M, Bureau JM, Temmar M, et al. Echogenic cerotid plaques are associated with aortic arterial stiffness in subjects with subclinical carotid atherosclerosis. Hypertension 2003; 41:519-527. This is the first study to show that echo-rich but not echolucent carotid plaques are associated with aortic arterial stiffness. These results reinforce the concept that echo-rich and echolucent plaques should be differentiated from each other and analyzed separately.
18. Grenholdt ML, Sillesen H, Wiebe BM, Laursen H, Nordestgaard BG. Increased acute phase reactants are associated with levels of lipoproteins and increased carotid plaque volume. Eur J Vasc Endovasc Surg 2001; 21:227-234.
19. Kofoed SC, Wittrup HH, Sillesen H, Nordestgaard BG. Fibrinogen predict ischaemic stroke and advanced atherosclerosis but not echolucent, rupture-prone carotid plaques: The Copenhagen City Heart study. Eur Heart J 2003; 24:567-576. This large prospective study demonstrated that elevated fibrinogen predicts ischaemic stroke, particularly in men and in the young and the middle aged. This is most likely a reflection of advanced atherosclerosis rather than an association with rupture-prone plaques.
20. Okulla T, Gass S, Böhme K, et al. Circulating adhesion molecules in patients with internal carotid artery stenosis. Cerebrovasc Dis 2002; 14:9-14.
21. Tanaka A, Kawarabayashi T, Taguchi H, et al. Use of preintervention intrasvascular ultrasound in patients with acute myocardial infarction. Am J Cardiol 2002; 89:257-261. The paper demonstrates that coronary echolucent plaques are the plaques most prone to reocclusion after primary balloon angioplasty for acute myocardial infarction.
22. Crisby M, Nordin-Fredriksson G, Shah PK, et al. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation 2001; 103:926-933.