High-dose insulin in experimental myocardial infarction in rabbits: Protection against effects of hyperglycaemia

Journal of Diabetes and its Complications

Volumn 25, Issue 2, 2011, Pages 122-128

  Wong, Vincent W ^a,b   Mardini, Mahidi ^a,c,d   Cheung, N Wah ^c,d   Mihailidou, Anastasia S ^a,c  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b LIVERPOOL HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d WESTMEAD HOSPITAL   (Australia)

Author keywords

Acute myocardial infarction; Apoptosis; Glucose; Insulin; Rabbits

Indexed keywords

GLUCOSE; INSULIN;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART PROTECTION; HYPERGLYCEMIA; ISOLATED HEART; MALE; MORBIDITY; MORTALITY; NONHUMAN; PREDICTOR VARIABLE; PRIORITY JOURNAL; RABBIT; REPERFUSION;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELLS, CULTURED; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERGLYCEMIA; INSULIN; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RABBITS;

EID: 79952317904     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2010.01.001     Document Type: Article

References (45)

1. Ambrosio G., and Flaherty J.T. Effects of the superoxide radical scavenger superoxide dismutase, and of the hydroxyl radical scavenger mannitol, on reperfusion injury in isolated rabbit hearts Cardiovascular Drugs and Therapy 6 1992 623 632 (Pubitemid 23045365)
2. Apstein C.S. Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury American Heart Journal 139 2000 S107 S114
3. Aronson D., Hammerman H., Kapeliovich M.R., Suleiman A., Agmon Y., Beyar R., Markiewicz W., and Suleiman M. Fasting glucose in acute myocardial infarction: Incremental value for long-term mortality and relationship with left ventricular systolic function Diabetes Care 30 2007 960 966 (Pubitemid 46556593)
4. Baines C.P., Wang L., Cohen M.V., and Downey J.M. Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart Basic Research in Cardiology 94 1999 188 198 (Pubitemid 29329303)
5. Bellodi G., Manicardi V., Malavasi V., Veneri L., Bernini G., Bossini P., Distefano S., Magnanini G., Rossi G., and Zuarini A. Hyperglycemia and prognosis of acute myocardial infarction in patients without diabetes mellitus American Journal of Cardiology 64 1989 885 888 (Pubitemid 19246163)
6. Burns R.J., Gibbons R.J., Yi Q., Roberts R.S., Miller T.D., Schaer G.L., Anderson J.L., and Yusuf S. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis Journal of the American College of Cardiology 39 2002 30 36 (Pubitemid 34059858)
7. Cai L., Li W., Wang G., Guo L., Jiang Y., and Kang Y.J. Hyperglycemia-induced apoptosis in mouse myocardium: Mitochondrial cytochrome C-mediated caspase-3 activation pathway Diabetes 51 2002 1938 1948 (Pubitemid 34564309)
8. Capes S.E., Hunt D., Malmberg K., and Gerstein H.C. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview Lancet 355 2000 773 778 (Pubitemid 30128815)
9. Cave A.C., Ingwall J.S., Friedrich J., Liao R., Saupe K.W., Apstein C.S., and Eberli F.R. ATP synthesis during low-flow ischemia: Influence of increased glycolytic substrate Circulation 101 2000 2090 2096 (Pubitemid 30233174)
10. Cheng W., Kajstura J., Nitahara J.A., Li B., Reiss K., Liu Y., Clark W.A., Krajewski S., Reed J.C., Olivetti G., and Anversa P. Programmed myocyte cell death affects the viable myocardium after infarction in rats Experimental Cell Research 226 1996 316 327 (Pubitemid 26260556)
11. Cheung N.W., Wong V.W., and McLean M. The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: A randomized controlled trial of insulin infusion therapy for myocardial infarction Diabetes Care 29 2006 765 770 (Pubitemid 44115291)
12. Dandona P., Chaudhuri A., Ghanim H., and Mohanty P. Proinflammatory effects of glucose and anti-inflammatory effect of insulin: Relevance to cardiovascular disease Journal of the American College of Cardiology 99 2007 15B 26B
13. De Sutter J., Tavernier R., Van de Wiele C., Kazmierckzak J., De Buyzere M., Jordaens L., Clement D.L., and Dierckx R.A. Infarct size and recurrence of ventricular arrhythmias after defibrillator implantation European Journal of Nuclear Medicine 27 2000 807 815 (Pubitemid 30456763)
14. Diaz R., Paolasso E.A., Piegas L.S., Tajer C.D., Moreno M.G., Corvalan R., Isea J.E., and Romero G. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group Circulation 98 1998 2227 2234 (Pubitemid 28533839)
15. Esposito K., Marfella R., and Giugliano D. Hyperglycemia and heart dysfunction: An oxidant mechanism contributing to heart failure in diabetes Journal of Endocrinological Investigation 25 2002 485 488 (Pubitemid 34516599)
16. Falck G., Schjott J., and Jynge P. Hyperosmotic pretreatment reduces infarct size in the rat heart Physiological Research 48 1999 331 340 (Pubitemid 29529123)
17. Gan R.M., Wong V.W., Cheung N.W., and Mclean M. Effect of insulin infusion on electrographic findings following acute myocardial infarction: Importance of glycaemic control Diabetic Medicine 26 2009 174 176
18. Gao F., Gao E., Yue T.L., Ohlstein E.H., Lopez B.L., Christopher T.A., and Ma X.L. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 2002 1497 1502 (Pubitemid 34263284)
19. Garcia-Dorado D., Theroux P., Munoz R., Alonso J., Elizaga J., Fernandez-Aviles F., Botas J., Solares J., Soriano J., and Duran J.M. Favorable effects of hyperosmotic reperfusion on myocardial edema and infarct size American Journal of Physiology. Heart and Circulatory Physiology 262 1992 H17 H22
20. Gottlieb R.A., Burleson K.O., Kloner R.A., Babior B.M., and Engler R.L. Reperfusion injury induces apoptosis in rabbit cardiomyocytes Journal of Clinical Investigation 94 1994 1621 1628 (Pubitemid 24309885)
21. Hadjadj S., Coisne D., Mauco G., Ragot S., Duengler F., Sosner P., Torremocha F., Herpin D., and Marechaud R. Prognostic value of admission plasma glucose and HbA in acute myocardial infarction Diabetic Medicine 21 2004 305 310 (Pubitemid 38519663)
22. Jonassen A.K., Aasum E., Riemersma R.A., Mjos O.D., and Larsen T.S. Glucose-insulin-potassium reduces infarct size when administered during reperfusion Cardiovascular Drugs and Therapy 14 2000 615 623 (Pubitemid 32217184)
23. Jonassen A.K., Brar B.K., Mjos O.D., Sack M.N., Latchman D.S., and Yellon D.M. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism Journal of Molecular and Cellular Cardiology 32 2000 757 764 (Pubitemid 30658913)
24. Justicz A.G., Farnsworth W.V., Soberman M.S., Tuvlin M.B., Bonner G.D., Bonner G.D., Hunter R.L., Martino-Saltzman D., Sink J.D., and Austin G.E. Reduction of myocardial infarct size by poloxamer 188 and mannitol in a canine model American Heart Journal 122 1991 671 680
25. Kosiborod M., Inzucchi S.E., and Krumholz H.M. Glucometrics in patients hospitalized with acute myocardial infarction: Defining the optimal outcomes-based measure of risk Circulation 117 2008 1018 1271
26. LaDisa J.F. Jr., Krolikowski J.G., Pagel P.S., Warltier D.C., and Kersten J.R. Cardioprotection by glucose-insulin-potassium: Dependence on KATP channel opening and blood glucose concentration before ischemia American Journal of Physiology. Heart and Circulatory Physiology 287 2004 H601 H607
27. Malmberg K., Ryden L., Efendic S., Herlitz J., Nicol P., Waldenstrom A., Wedel H., and Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year Journal of the American College of Cardiology 26 1995 57 65
28. Malmberg K., Ryden L., Wedel H., Birkeland K., Bootsma A., Dickstein K., Efendic S., Fisher M., Hamsten A., Herlitz J., Hildebrandt P., Macleod K., Laakso M., Torp-Pedersen C., and Waldenstrom A. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): Effects on mortality and morbidity European Heart Journal 26 2005 650 661 (Pubitemid 40516876)
29. Marfella R., D'Amico M., Di Filippo C., Piegari E., Nappo F., Esposito K., Berrino L., Rossi F., and Giugliano D. Myocardial infarction in diabetic rats: Role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1 Diabetologia 45 2002 1172 1181 (Pubitemid 34985294)
30. Mehta S.R., Yusuf S., Diaz R., Zhu J., Pais P., Xavier D., Paolasso E., Ahmed R., Xie C., Kazmi K., Tai J., Orlandini A., Pogue J., and Liu L. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: The CREATE-ECLA randomized controlled trial Journal of the American Medical Association 293 2005 437 446
31. Miller T.D., Hodge D.O., Sutton J.M., Grines C.L., O'Keefe J.H., DeWood M.A., Okada R.D., Fletcher W.O. Jr., and Gibbons R.J. Usefulness of technetium-99m sestamibi infarct size in predicting posthospital mortality following acute myocardial infarction Journal of the American College of Cardiology 81 1998 1491 1493 (Pubitemid 28283833)
32. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 2000 787 790 (Pubitemid 30212409)
33. Oliver M.F. Antilipolytic drugs for the prevention of primary ventricular fibrillation Diabetes, Obesity & Metabolism 3 2001 61 65 (Pubitemid 32782854)
34. Olivetti G., Quaini F., Sala R., Lagrasta C., Corradi D., Bonacina E., Gambert S.R., Cigola E., and Anversa P. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart Journal of Molecular and Cellular Cardiology 28 1996 2005 2016 (Pubitemid 26340560)
35. Pisarenko O.I., Serebryakova L.I., Studneva I.M., and Tskitishvili O.V. Metabolic correction reduces the area of acute ischemic myocardial infarction in rats Bulletin of Experimental Biology and Medicine 141 2006 296 298 (Pubitemid 43905093)
36. Rasoul S., Ottervanger J.P., Timmer J.R., Svilaas T., Henriques J.P., Dambrink J.H., van der Horst I.C., and Zijlstra F. One year outcomes after glucose-insulin-potassium in ST elevation myocardial infarction. The Glucose-insulin-potassium study II International Journal of Cardiology 122 1 2007 52 55 (Pubitemid 47503354)
37. Rytter L., Troelsen S., and Beck-Nielsen H. Prevalence and mortality of acute myocardial infarction in patients with diabetes Diabetes Care 8 1985 230 234 (Pubitemid 15071437)
38. Shizukuda Y., Reyland M.E., and Buttrick P.M. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes American Journal of Physiology. Heart and Circulatory Physiology 282 2002 H1625 H1634
39. Su H., Sun X., Ma H., Zhang H.F., Yu Q.J., Huang C., Wang X.M., Luan R.H., Jia G.L., Wang H.C., and Gao F. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK American Journal of Physiology. Endocrinology and Metabolism 293 2007 E629 E635
40. Sundell J., and Knuuti J. Insulin and myocardial blood flow Cardiovasc Res 57 2003 312 319 (Pubitemid 36144210)
41. Tansey M.J., and Opie L.H. Plasma glucose on admission to hospital as a metabolic index of the severity of acute myocardial infarction Canadian Journal of Cardiology 2 1985 326 331 (Pubitemid 17191789)
42. Tune J.D., Mallet R.T., and Downey H.F. Insulin improves contractile function during moderate ischemia in canine left ventricle American Journal of Physiology. Heart and Circulatory Physiology 74 1998 H1574 H1581
43. van der Horst I.C., Zijlstra F., van't Hof A.W., Doggen C.J., de Boer M.J., Suryapranata H., Hoorntje J.C., Dambrink J.H., Gans R.O., and Bilo H.J. Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: The glucose-insulin-potassium study: A randomized trial Journal of the American College of Cardiology 42 2003 784 791 (Pubitemid 37059733)
44. Wong V.W., Ross D.L., Park K., Boyages S.C., and Cheung N.W. Hyperglycemia Still an important Predictor of Adverse Outcomes following AMI in the reperfusion era Diabetes Research and Clinical Practice 64 2004 85 91 (Pubitemid 38456686)
45. Zeller M., Verges B., L'Huillier I., Brun J.M., and Cottin Y. Glycemia in acute coronary syndromes Diabetes & Metabolism 32 2 2006 S42 S47