A rapid method for assessment of natural killer cell function after multiple receptor crosslinking

Journal of Immunological Methods

Volumn 366, Issue 1-2, 2011, Pages 52-59

  Al Hubeshy, Z B ^a   Coleman, A ^a   Nelson, M ^b   Goodier, M R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Degranulation; IFN ; Monoclonal antibodies; NK cell receptors; PBMC.

Indexed keywords

CD16 ANTIGEN; GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MONOCLONAL ANTIBODY; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DEGRANULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; CELL DEGRANULATION; CELL SEPARATION; CROSS-LINKING REAGENTS; CYTOKINES; FLOW CYTOMETRY; HUMANS; IMMUNOASSAY; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY C; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; RECEPTORS, NATURAL KILLER CELL;

EID: 79952311615     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2011.01.007     Document Type: Article

References (21)

1. Aktas E., Kucuksezer U.C., Bilgic S., Erten G., Deniz G. Relationship between CD107a expression and cytotoxic activity. Cell. Immunol. 2009, 254:149.
2. Alter G., Malenfant J.M., Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods 2004, 294:15.
3. Augugliaro R., Parolini S., Castriconi R., Marcenaro E., Cantoni C., Nanni M., Moretta L., Moretta A., Bottino C. Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. Eur. J. Immunol. 2003, 33:1235.
4. Betts M.R., Brenchley J.M., Price D.A., De Rosa S.C., Douek D.C., Roederer M., Koup R.A. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 2003, 281:65.
5. Brunetta E., Fogli M., Varchetta S., Bozzo L., Hudspeth K.L., Marcenaro E., Moretta A., Mavilio D. Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. AIDS 2010, 24:27.
6. Bryceson Y.T., Ljunggren H.G., Long E.O. Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood 2009, 114:2657.
7. Bryceson Y.T., March M.E., Barber D.F., Ljunggren H.G., Long E.O. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J. Exp. Med. 2005, 202:1001.
8. Bryceson Y.T., March M.E., Ljunggren H.G., Long E.O. Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 2006, 107:159.
9. De Maria A., Fogli M., Costa P., Murdaca G., Puppo F., Mavilio D., Moretta A., Moretta L. The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur. J. Immunol. 2003, 33:2410.
10. Fehniger T.A., Cooper M.A., Nuovo G.J., Cella M., Facchetti F., Colonna M., Caligiuri M.A. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 2003, 101:3052.
11. Ferlazzo G., Thomas D., Lin S.L., Goodman K., Morandi B., Muller W.A., Moretta A., Munz C. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J. Immunol. 2004, 172:1455.
12. Goodier M.R. Intestinal NK cells. Natural Killer Cells 2010, 331. Elsevier, Academic Press, San Diego, CA. Lotze, M.T, Thomson, A.W. (Eds.).
13. Guma M., Angulo A., Vilches C., Gomez-Lozano N., Malats N., Lopez-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 2004, 104:3664.
14. Guma M., Cabrera C., Erkizia I., Bofill M., Clotet B., Ruiz L., Lopez-Botet M. Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients. J. Infect. Dis. 2006, 194:38.
15. Long B.R., Erickson A.E., Chapman J.M., Barbour J.D., Vu B.A., Ho E.L., Lanier L.L., Sauer M.M., Carvalho K.I., Nixon D.F., Kallas E.G. Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2. Immunology 2009, 129:186.
16. Mela C.M., Burton C.T., Imami N., Nelson M., Steel A., Gazzard B.G., Gotch F.M., Goodier M.R. Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy. AIDS 2005, 19:1761.
17. Mela C.M., Steel A., Lindsay J., Gazzard B.G., Gotch F.M., Goodier M.R. Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals. AIDS 2007, 21:2177.
18. Pende D., Parolini S., Pessino A., Sivori S., Augugliaro R., Morelli L., Marcenaro E., Accame L., Malaspina A., Biassoni R., Bottino C., Moretta L., Moretta A. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 1999, 190:1505.
19. Spaggiari G.M., Carosio R., Pende D., Marcenaro S., Rivera P., Zocchi M.R., Moretta L., Poggi A. NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur. J. Immunol. 2001, 31:1656.
20. Takayama T., Kamada N., Chinen H., Okamoto S., Kitazume M.T., Chang J., Matuzaki Y., Suzuki S., Sugita A., Koganei K., Hisamatsu T., Kanai T., Hibi T. Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 2010, 139:882.
21. Zimmer J., Andres E., Hentges F. NK cell subsets and CD107a mobilization assay. Leukemia 2005, 19:1849. author reply 1857.