Overview of peptide and protein PEGylation: Properties and general strategies

Acta Pharmaceutica Sciencia

Volumn 52, Issue 4, 2010, Pages 376-388

  Sezer, Ali Demir ^a   Yaǧci, Ahmet Furkan ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

Conjugation; PEG; PEG protein; PEGylation; PEGylation chemistry

Indexed keywords

AMINO ACID; ASPARAGINASE MACROGOL; BILIRUBIN OXIDASE; CARBONIC ACID; CATALASE; COLONY STIMULATING FACTOR; CYTOKINE; EPOXIDE; ESTER; FLUORIDE; HEMOGLOBIN; HIRUDIN; HYDROSUCCINIMIDYL ESTER; IMIDAZOLE DERIVATIVE; IMMUNOGLOBULIN G; LIPOSOME; LIVER PROTECTIVE AGENT; MACROGOL DERIVATIVE; OXYCARBONYLIMIDAZOLE; PEGADEMASE; PURINE NUCLEOSIDE PHOSPHORYLASE; STREPTOKINASE; SUCCINIMIDYL CARBONATE; SUPEROXIDE DISMUTASE MACROGOL; TRESYL FLUORIDE; TRIAZINE; TRICHLOROPHENYLCARBONATE; TRYPTOPHANASE; UNCLASSIFIED DRUG; UROKINASE;

ACUTE LYMPHOCYTIC LEUKEMIA; ADENOSINE DEAMINASE DEFICIENCY; ALLERGIC REACTION; ANAPHYLACTIC SHOCK; CANCER THERAPY; DEEP VEIN THROMBOSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG STABILITY; HEMOLYTIC ANEMIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERBILIRUBINEMIA; HYPERSENSITIVITY REACTION; INFLAMMATORY DISEASE; LOW DRUG DOSE; LUNG EMBOLISM; LYMPHOCYTOMA; MOLECULAR WEIGHT; MYOCARDIAL DISEASE; NONHUMAN; PEGYLATION; PHARMACOLOGICAL PROCEDURES; PLASMA CLEARANCE; PROTEIN STRUCTURE; REDUCTION KINETICS; REVIEW; STRUCTURE ANALYSIS;

EID: 79952301089     PISSN: 13072080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Brocchini, S., Godwin, A., Balan, S., Won Choi, J., Zloh, M. and Shaunak, S. (2008). Disulfide bridge based PEGylation of proteins. Adv. Drug Del. Rev. 60: 3-12.
2. Chen, X., Park, R., Shahinia, A.H., Bading, J.R. and Conti, P.S. (2004). Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation. Nuc. Med. Biol. 31: 11-19.
3. Colonna, C., Conti, B., Perugini, P., Pavanetto, F., Modena, T., Dorati, R., Iadarola, P. and Genta, I. (2008). Sitedirected PEGylation as successful approach to improve the enzyme replacement in the case of prolidase. Int. J. Pharm. 358: 230-237.
4. Fee, C.J. and Van Alstine, J.M. (2006). PEG-proteins: reaction engineering and separation issues. Chem. Eng. Sci. 61: 924-939.
5. Filpula, D. and Zhao H. (2008). Releasable PEGylation of proteins with customized linkers. Adv. Drug Deliv. Rev. 60: 29-49.
6. Fontana, A., Spolaore, B., Mero, A. and Veronese, F.M. (2008). Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase. Adv. Drug Del. Rev. 60: 13-28.
7. Hou, B., Li, S., Li, X. and Xiu, Z. (2007). Design, Preparation and in vitro bioactivity of mono-PEGylated recombinant hirudin. Chin. J. Chem. Eng. 15(6): 775-780.
8. ®. J. Control. Rel. 97: 157-171.
9. Kodera, Y., Matsushima, A., Hiroto, M., Nishimura, H., Ishi, A., Ueno, T. and Inada, Y. (1998). Pegylati{dotless}on of proteins and bioacti{dotless}ve substances for medical and technical applications. Prog. Polym. Sci. 23: 1233-1271.
10. Kozlowski, A. and Haris, J.M. (2001). Improvements in protein pegylation: pegylated interferons for treatment of hepatitis C. J. Control. Rel. 72: 217-224.
11. Madani, F., Bessodes, M., Lakrouf, A., Vauthier, C., Scherman, D., Chaumeil, J.C. (2007). PEGylation of microspheres for therapeutic embolization: preparation, characterization and biological performance evaluation. Biomaterials. 28: 1198-1208.
12. Molineux, G. (2002). Pegylation: engineering improved pharmaceuticals for enhanced therapy. Cancer Treat. Rev. 28 (Suppl. A): 13-16.
13. Pasut, G. and Veronese, F.M. (2007). Polymer-drug conjugation, recent achievements and general strategies. Prog. Polym. Sci. 32: 933-961.
14. Qin H., Xiu Z., Zhang D., Bao Y., Li X. and Han G. (2007). PEGylation of hirudin and analysis of its antithrombin activity in vitro. Chin. J. Chem. Eng., 15(4): 586-590.
15. Roberts, M.J., Bentley, M.D. and Haris, J.M. (2002). Chemistry for peptide and protein PEGylation. Adv. Drug Deliv. Rev. 54: 459-476.
16. Sato, H. (2002). Enzymatic procedure for site-specific pegylation of proteins. Adv.Drug Del. Rev. 54: 487-504.
17. Tamariz, F.L., Verbaeys, I., Boven, M., De Cuyper, M., Buyse, J., Clynen, E. and Cokelaere, M. (2007). PEGylation of cholecystokinin prolongs its anorectic effect in rats. Peptides. 28: 1003-1011.
18. Üstündaǧ, Y. (2007). Pegile interferonlar: gelisim, farmakokinetik ve farmakodinamik özellikleri. Güncel Gastroenteroloji 11(3): 139-147.
19. Veronese, F.M. (2001). Peptide and protein PEGylation: a review of problems and solutions. Biomaterials. 22: 405-417.
20. Veronese, F.M. and Haris, J.M. (2002). Introduction and overview of peptide and protein pegylation. Adv. Drug Del. Rev. 54: 453-456.
21. Veronese, F.M. and Pasut, G. (2005). PEGylation, successful approach to drug delivery. Drug Discov. Today 10: 1451-1458.
22. Zappe, H., Snell, M.E. and Bossard, M.J. (2008). PEGylation of cyanovirin-N, an entry inhibitor of HIV. Adv. Drug Del. Rev. 60: 79-87.