Robustness testing, using experimental design, of a flow-through dissolution method for a product where the actives have markedly differing solubility properties

International Journal of Pharmaceutics

Volumn 206, Issue 1-2, 2000, Pages 55-61

  Bloomfield, M S ^a   Butler, W C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Experimental design; Factorial design Atovaquone; Flow through dissolution; Malarone; Proguanil hydrochloride

Indexed keywords

ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; PROGUANIL;

ARTICLE; DISSOLUTION; DRUG SOLUBILITY; FLOW RATE; PRIORITY JOURNAL; TABLET;

ANTIMALARIALS; CAUSTICS; CHEMISTRY, PHARMACEUTICAL; CHLOROGUANIDE; DRUG COMBINATIONS; NAPHTHOQUINONES; SODIUM HYDROXIDE; SOLUBILITY; TABLETS;

EID: 0034714882     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00509-3     Document Type: Article

References (5)

1. A flow-through dissolution method for a two component drug formulation where the actives have markedly differing solubility properties
2. An experimental design approach to the optimisation of a flow injection analysis method for glycine