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Volumn 30, Issue 9, 2011, Pages 1046-1058

Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome

Author keywords

breast cancer; CD105; endoglin; ErbB2; MCF10A; TGF

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANTHRACYCLINE DERIVATIVE; AP 1510; AZACITIDINE; ENDOGLIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SHORT HAIRPIN RNA; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 79952283351     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.488     Document Type: Article
Times cited : (55)

References (40)
  • 2
    • 0033534572 scopus 로고    scopus 로고
    • Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta super-family
    • Barbara NP, Wrana JL, Letarte M. (1999). Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta super-family. J Biol Chem 274: 584-594.
    • (1999) J Biol Chem , vol.274 , pp. 584-594
    • Barbara, N.P.1    Wrana, J.L.2    Letarte, M.3
  • 3
    • 36849054447 scopus 로고    scopus 로고
    • Novel biochemical pathways of endoglin in vascular cell physiology
    • DOI 10.1002/jcb.21594
    • Bernabeu C, Conley BA, Vary CP. (2007). Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem 102: 1375-1388. (Pubitemid 350223941)
    • (2007) Journal of Cellular Biochemistry , vol.102 , Issue.6 , pp. 1375-1388
    • Bernabeu, C.1    Conley, B.A.2    Vary, C.P.H.3
  • 4
    • 70349273685 scopus 로고    scopus 로고
    • The emerging role of TGF-beta superfamily coreceptors in cancer
    • Bernabeu C, Lopez-Novoa JM, Quintanilla M. (2009). The emerging role of TGF-beta superfamily coreceptors in cancer. Biochim Biophys Acta 1792: 954-973.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 954-973
    • Bernabeu, C.1    Lopez-Novoa, J.M.2    Quintanilla, M.3
  • 6
    • 0026646785 scopus 로고
    • Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    • Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J et al. (1992). Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 267: 19027-19030.
    • (1992) J Biol Chem , vol.267 , pp. 19027-19030
    • Cheifetz, S.1    Bellon, T.2    Cales, C.3    Vera, S.4    Bernabeu, C.5    Massague, J.6
  • 7
  • 8
    • 36048973196 scopus 로고    scopus 로고
    • Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway
    • DOI 10.1038/sj.onc.1210533, PII 1210533
    • Craft CS, Romero D, Vary CP, Bergan RC. (2007). Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway. Oncogene 26: 7240-7250. (Pubitemid 350085322)
    • (2007) Oncogene , vol.26 , Issue.51 , pp. 7240-7250
    • Craft, C.S.1    Romero, D.2    Vary, C.P.H.3    Bergan, R.C.4
  • 9
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • DOI 10.1038/nrc1695, PII N1695
    • Debnath J, Brugge JS. (2005). Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675-688. (Pubitemid 41486361)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.9 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 10
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through smads
    • DOI 10.1146/annurev.cellbio.21.022404.142018
    • Feng XH, Derynck R. (2005). Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 21: 659-693. (Pubitemid 41740650)
    • (2005) Annual Review of Cell and Developmental Biology , vol.21 , pp. 659-693
    • Feng, X.-H.1    Derynck, R.2
  • 11
    • 0037047426 scopus 로고    scopus 로고
    • Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors i and II
    • Guerrero-Esteo M, Sanchez-Elsner T, Letamendia A, Bernabeu C. (2002). Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem 277: 29197-29209.
    • (2002) J Biol Chem , vol.277 , pp. 29197-29209
    • Guerrero-Esteo, M.1    Sanchez-Elsner, T.2    Letamendia, A.3    Bernabeu, C.4
  • 13
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands-'a rough guide'
    • Illingworth RS, Bird AP. (2009). CpG islands-'a rough guide'. FEBS Lett 583: 1713-1720.
    • (2009) FEBS Lett , vol.583 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 14
    • 73349089657 scopus 로고    scopus 로고
    • Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation
    • Ishibashi O, Ikegame M, Takizawa F, Yoshizawa T, Moksed MA, Iizawa F et al. (2010). Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation. J Cell Physiol 222: 465-473.
    • (2010) J Cell Physiol , vol.222 , pp. 465-473
    • Ishibashi, O.1    Ikegame, M.2    Takizawa, F.3    Yoshizawa, T.4    Moksed, M.A.5    Iizawa, F.6
  • 15
    • 0030050973 scopus 로고    scopus 로고
    • Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
    • Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon SJ et al. (1996). Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 13: 189-195.
    • (1996) Nat Genet , vol.13 , pp. 189-195
    • Johnson, D.W.1    Berg, J.N.2    Baldwin, M.A.3    Gallione, C.J.4    Marondel, I.5    Yoon, S.J.6
  • 18
    • 34547111838 scopus 로고    scopus 로고
    • The interaction of endoglin with β-arrestin2 regulates transforming growth factor-β-mediated ERK activation and migration in endothelial cells
    • DOI 10.1074/jbc.M700176200
    • Lee NY, Blobe GC. (2007). The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. J Biol Chem 282: 21507-21517. (Pubitemid 47099970)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.29 , pp. 21507-21517
    • Lee, N.Y.1    Blobe, G.C.2
  • 19
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. (2008). TGFbeta in Cancer. Cell 134: 215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 20
    • 0028171579 scopus 로고
    • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiec-tasia type 1
    • McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE et al. (1994). Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiec-tasia type 1. Nat Genet 8: 345-351.
    • (1994) Nat Genet , vol.8 , pp. 345-351
    • McAllister, K.A.1    Grogg, K.M.2    Johnson, D.W.3    Gallione, C.J.4    Baldwin, M.A.5    Jackson, C.E.6
  • 21
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A, Heldin CH. (2005). Non-Smad TGF-beta signals. J Cell Sci 118: 3573-3584.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 22
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • DOI 10.1038/ncb0901-785
    • Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3: 785-792. (Pubitemid 32842683)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 23
    • 66249141288 scopus 로고    scopus 로고
    • The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrest-in2-mediated activation of Cdc42
    • Mythreye K, Blobe GC. (2009). The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrest-in2-mediated activation of Cdc42. Proc Natl Acad Sci USA 106: 8221-8226.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8221-8226
    • Mythreye, K.1    Blobe, G.C.2
  • 24
    • 44849103617 scopus 로고    scopus 로고
    • Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype
    • DOI 10.1038/sj.onc.1211025, PII 1211025
    • Oxmann D, Held-Feindt J, Stark AM, Hattermann K, Yoneda T, Mentlein R. (2008). Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype. Oncogene 27: 3567-3575. (Pubitemid 351793804)
    • (2008) Oncogene , vol.27 , Issue.25 , pp. 3567-3575
    • Oxmann, D.1    Held-Feindt, J.2    Stark, A.M.3    Hattermann, K.4    Yoneda, T.5    Mentlein, R.6
  • 25
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
    • DOI 10.1126/science.1105718
    • Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. (2005). Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307: 1603-1609. (Pubitemid 40354739)
    • (2005) Science , vol.307 , Issue.5715 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.-R.4    Zhang, Y.5    Wrana, J.L.6
  • 26
    • 41149157649 scopus 로고    scopus 로고
    • TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
    • DOI 10.1016/j.cell.2008.01.046, PII S0092867408002110
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR et al. (2008). TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77. (Pubitemid 351442989)
    • (2008) Cell , vol.133 , Issue.1 , pp. 66-77
    • Padua, D.1    Zhang, X.H.-F.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 28
    • 0141594914 scopus 로고    scopus 로고
    • Expression of the TGF-β coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis
    • DOI 10.1038/sj.onc.1206841
    • Quintanilla M, Ramirez JR, Perez-Gomez E, Romero D, Velasco B, Letarte M et al. (2003). Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis. Oncogene 22: 5976-5985. (Pubitemid 37179945)
    • (2003) Oncogene , vol.22 , Issue.38 , pp. 5976-5985
    • Quintanilla, M.1    Ramirez, J.R.2    Perez-Gomez, E.3    Romero, D.4    Velasco, B.5    Letarte, M.6    Lopez-Novoa, J.M.7    Bernabeu, C.8
  • 31
    • 77950911663 scopus 로고    scopus 로고
    • Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration
    • Romero D, Terzic A, Conley BA, Craft CS, Jovanovic B, Bergan RC et al. (2010). Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis 31: 359-366.
    • (2010) Carcinogenesis , vol.31 , pp. 359-366
    • Romero, D.1    Terzic, A.2    Conley, B.A.3    Craft, C.S.4    Jovanovic, B.5    Bergan, R.C.6
  • 34
    • 34347230515 scopus 로고    scopus 로고
    • Endoglin differentially modulates antagonistic transforming growth factor-β1 and BMP-7 signaling
    • DOI 10.1074/jbc.M611062200
    • Scherner O, Meurer SK, Tihaa L, Gressner AM, Weiskirchen R. (2007). Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling. J Biol Chem 282: 13934-13943. (Pubitemid 47100463)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 13934-13943
    • Scherner, O.1    Meurer, S.K.2    Tihaa, L.3    Gressner, A.M.4    Weiskirchen, R.5
  • 36
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J. (2003). Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 37
    • 41049094560 scopus 로고    scopus 로고
    • Endoglin in angiogenesis and vascular diseases
    • ten Dijke P, Goumans MJ, Pardali E. (2008). Endoglin in angiogenesis and vascular diseases. Angiogenesis 11: 79-89.
    • (2008) Angiogenesis , vol.11 , pp. 79-89
    • Ten Dijke, P.1    Goumans, M.J.2    Pardali, E.3
  • 38
    • 0036222784 scopus 로고    scopus 로고
    • Adhesion assembly, disassembly and turnover in migrating cells - Over and over and over again
    • Webb DJ, Parsons JT, Horwitz AF. (2002). Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol 4: E97-100.
    • (2002) Nat Cell Biol , vol.4
    • Webb, D.J.1    Parsons, J.T.2    Horwitz, A.F.3
  • 39
    • 57349117010 scopus 로고    scopus 로고
    • Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma
    • Wong VC, Chan PL, Bernabeu C, Law S, Wang LD, Li JL et al. (2008). Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma. Int J Cancer 123: 2816-2823.
    • (2008) Int J Cancer , vol.123 , pp. 2816-2823
    • Wong, V.C.1    Chan, P.L.2    Bernabeu, C.3    Law, S.4    Wang, L.D.5    Li, J.L.6
  • 40
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • Zhang YE. (2009). Non-Smad pathways in TGF-beta signaling. Cell Res 19: 128-139.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.