Single nucleotide polymorphisms within functional regions of genes implicated in insulin action and association with the insulin resistant phenotype

Molecular and Cellular Biochemistry

Volumn 349, Issue 1-2, 2011, Pages 187-193

  Malodobra, Malgorzata ^b   Pilecka, Agnieszka ^a   Gworys, Bohdan ^a   Adamiec, Rajmund ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b NONE

Author keywords

Insulin resistance; Insulin signaling; Single nucleotide polymorphism; Type 2 diabetes; Untranslated region

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PROTEIN TYROSINE PHOSPHATASE 1B;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC ASSOCIATION STUDIES; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN RESISTANCE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTOR, INSULIN; UNTRANSLATED REGIONS;

EID: 79952282524     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0673-5     Document Type: Article

References (27)

1. RA Kohanski 1993 Insulin receptor autophosphorylation. I. Autophosphorylation kinetics of the native receptor and its cytoplasmic kinase domain Biochemistry 32 5766 5772 1:CAS:528:DyaK3sXktVWgt7s%3D 10.1021/bi00073a007 8504095 (Pubitemid 23175677)
2. S Boura-Halfon Y Zick 2009 Phosphorylation of IRS protein, insulin action and insulin resistance Am J Physiol Endocrinol Metab 296 581 591 10.1152/ajpendo.90437.2008
3. PT Hawkins KE Anderson K Davidson LR Stephens 2006 Signalling through Class I PI3Ks in mammalian cells Biochem Soc Trans 34 647 662 1:CAS:528:DC%2BD28XhtFWnsLvO 10.1042/BST0340647 17052169 (Pubitemid 44796393)
4. RF Pilch 2008 The mass action hypothesis: formation of Glut4 storage vesicles, a tissue-specific, regulated exocytic compartment Acta Physiol 192 89 101 1:CAS:528:DC%2BD1cXhsVaisro%3D 10.1111/j.1748-1716.2007.01788.x (Pubitemid 350265368)
5. AH Khan JE Pessin 2002 Insulin regulation of glucose uptake: a complex interplay of intracellular signaling pathway Diabetologia 45 1475 1483 1:CAS:528:DC%2BD38XoslOrs74%3D 10.1007/s00125-002-0974-7 12436329 (Pubitemid 35352039)
6. RA DeFronzo 1997 Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes Diabetes Rev 5 177 269
7. V Harmelen M Ryden E Sjölin J Hoffstedt 2007 A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression J Lipid Res 48 201 206 10.1194/jlr.M600272-JLR200 17035674 (Pubitemid 46052912)
8. J Dupuis C Langenberg I Prokopenko, et al. 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105 116 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 10.1038/ng.520 20081858
9. MI McCarthy E Zeggini 2009 Genome-wide association studies in type 2 diabetes Curr Diabetes Rep 9 164 171 1:CAS:528:DC%2BC3cXhtFersrrI 10.1007/s11892-009-0027-4
10. H Beck-Nielsen 2003 Metabolic and genetic influence on glucose metabolism in type 2 diabetes subjects-experiments from relatives and twin studies Best Pract Res Clin Endocrinol Metab 17 445 467 1:CAS:528:DC%2BD3sXmvVKmsb0%3D 10.1016/S1521-690X(03)00041-1 12962696
11. ME Patti 2004 Gene expression in human with diabetes and prediabetes: what have we learned about diabetes pathophysiology Curr Opin Clin Nutr Metab Care 7 383 390 1:CAS:528:DC%2BD2cXmsVShsLY%3D 10.1097/01.mco.0000134359.23288.72 15192439 (Pubitemid 40340643)
12. F Mignone C Gissi S Liuni G Pesole 2002 Untranslated regions of mRNAs Genome Biol 3 1 10 10.1186/gb-2002-3-3-reviews0004
13. B Conne A Stutz F-D Vassalli 2000 The 3′ untranslated region of messenger RNA: a molecular "hotspot" for pathology? Nat Med 6 637 641 1:CAS:528:DC%2BD3cXkt12juro%3D 10.1038/76211 10835679 (Pubitemid 30398786)
14. J-M Chen C Férec DN Cooper 2006 A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants Hum Genet 120 301 333 1:CAS:528:DC%2BD28Xps1Ort7g%3D 10.1007/s00439-006-0218-x 16807757 (Pubitemid 44400467)
15. RL Nelsoe YH Hamid F Pociot S Paulsen KM Andersen K Borch-Johnsen T Drivsholm T Hansen O Pedersen T Mandrup-Poulsen 2006 Association of a microsatellite in FASL to type 2 diabetes and of the FAS-670G>A genotype in insulin resistance Genes Immun 7 316 321 10.1038/sj.gene.6364300 (Pubitemid 43871532)
16. R Di Paola Z Frittitta G Miscio M Bozzali R Baratta M Centra D Spampinato MG Santagati T Ercolino C Cisternino T Soccio S Mastroianno V Tassi P Almgren A Pizzuti R Vigneri V Trischitta 2002 A variation in 3′ UTR of hPTPN1B increases specific gene expression and associated with insulin resistance Am J Hum Genet 70 806 812 1:CAS:528:DC%2BD38XislCht7o%3D 10.1086/339270 11833006 (Pubitemid 34177937)
17. J Xia C Bogardus M Prochazka 1999 A type 2 diabetes associated polymorphic ARE motif affecting expression of PPP1R3 is involved in RNA-protein interaction Mol Genet Metab 68 48 55 1:CAS:528:DyaK1MXlslenurw%3D 10.1006/mgme.1999.2884 10479482 (Pubitemid 29459693)
18. H Staiger F Machicao A Fritsche H-U Häring 2009 Pathomechanisms of type 2 diabetes genes Endocr Rev 30 557 585 1:CAS:528:DC%2BD1MXhsVyhsrbJ 10.1210/er.2009-0017 19749172
19. M Ruano V Silvestre R Castro MCG Garcia-Lescun E Aguirregoicoa A Marco A Rodriguez G Garcia-Blanch 2006 HOMA, QUICKI and MFfm to measure insulin resistance in morbid obesity Obes Surg 16 549 553 1:STN:280: DC%2BD283mtlOntA%3D%3D 10.1381/096089206776945048 16687020 (Pubitemid 43781037)
20. Hansen B, Shafrir E (2002) Insulin resistance and insulin resistance syndrome. Taylor & Francis, New York, NY
21. J Kusari FB Verma RR Henry JM Olefsky 1991 Analysis of the gene sequences of the insulin receptor and the insulin sensitive glucose transporter (GLUT4) in patients with common type non-dependent diabetes mellitus J Clin Invest 88 1323 1330 1:CAS:528:DyaK3MXmslaiurw%3D 10.1172/JCI115437 1918382
22. K Almind L Delahaye T Hansen E Van Obberghen O Pedersen CR Kahn 2002 Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α PNAS 99 2124 2128 1:CAS:528:DC%2BD38XitVSrtrY%3D 10.1073/pnas. 042688799 11842213 (Pubitemid 34169025)
23. K Baynes CA Beeton G Panayotou R Stein M Soos T Hansen H Simpson S O'Rahilly RP Shepherd JP Whitehead 2000 Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin stimulated lipid kinase activity Diabetologia 50 690 693
24. R Meshkani M Taghikhani H AlKateb B Larijani S Khatami GK Sidiropoulos RA Hegele K Adeli 2007 Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promotor: functional characterization and association with type 2 diabetes and related metabolic traits Clin Chem 53 1585 1592 1:CAS:528:DC%2BD2sXhtVSgu7fM 10.1373/clinchem.2007.088146 17634210 (Pubitemid 47340053)
25. S Lesage H Zouali N Vionnet A Philippi G Velho P Serradas P Passa F Demenais P Froguel 1997 Genetic analyses of glucose transporter gene in French non-insulin-dependent diabetes families Diabetes Metab 23 137 142 1:STN:280:DyaK2s3otlyhtg%3D%3D 9137902 (Pubitemid 27154196)
26. PR Shepherd BB Khan 1999 Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus N Engl J Med 341 248 257 1:CAS:528:DyaK1MXltVOju74%3D 10.1056/NEJM199907223410406 10413738 (Pubitemid 29334524)
27. P Piatkiewicz A Czech J Taton 2007 Glucose transport in human peripheral blood lymphocytes influenced by type 2 diabetes Arch Immunol Ther Exp 55 119 126 1:CAS:528:DC%2BD2sXlsFWgtr8%3D 10.1007/s00005-007-0015-9 (Pubitemid 46559202)