Receptor-based discovery strategies for insecticides and parasiticides: A review

Advances in Experimental Medicine and Biology

Volumn 692, Issue , 2010, Pages 1-9

  Woods, Debra ^a   Butler, Cheryl ^b   Williams, Tracey ^b   Greenwood, Karen ^b  

^a PFIZER INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL CHEMICAL; ANTIPARASITIC AGENT; DORAMECTIN; G PROTEIN COUPLED RECEPTOR; INSECTICIDE; IVERMECTIN; NATURAL PRODUCT; NEUROPEPTIDE RECEPTOR; SELAMECTIN; BIOLOGICAL PRODUCT; DRUG RECEPTOR;

CROP; DRUG DETERMINATION; DRUG DEVELOPMENT; DRUG SAFETY; DRUG SYNTHESIS; GENOMICS; HIGH THROUGHPUT SCREENING; HOST; NONHUMAN; PARASITE CONTROL; PATENT; PEST CONTROL; PRIORITY JOURNAL; REVIEW; VETERINARY MEDICINE; ANIMAL; DRUG EFFECT; DRUG SCREENING; INVERTEBRATE; METHODOLOGY; PHYSIOLOGY;

ANIMALS; ANTIPARASITIC AGENTS; BIOLOGICAL PRODUCTS; DRUG EVALUATION, PRECLINICAL; INSECTICIDES; INVERTEBRATES; RECEPTORS, DRUG; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 79952277981     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6902-6_1     Document Type: Review

References (29)

1. Nwaka S, Hudson A. Innovative lead discovery strategies for tropical diseases. Nat Rev Drug Discov 2006; 5:941-955. (Pubitemid 44660607)
2. Maule A, Geary T, Bowman J et al. Inhibitory effects of nematode fmrfamide-related peptides (farps) on muscle strips from Ascaris suum. Inv Neurosci 1995; 1(3):255-265.
3. Greenwood K, Williams T, Geary T. Nematode neuropeptide receptors and their development as anthelmintic screens. Parasitology 2005; 131:S169-S177.
4. Ward E, Bernasconi P. Target-based discovery of crop protection chemicals. Nat Biotech 1999; 7:618-619. (Pubitemid 29316123)
5. Lee B, Dutton F, Clothier M et al. Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay. Bioorg Med Chem Lett 1999; 9:1727-1732. (Pubitemid 29278862)
6. Hauser F, Williamson M, Cazzamali G et al. Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data. Brief Funct Genomic Proteomic 2006; 4(4):321-330.
7. Lowery D, Geary T, Kubiak T et al. G-protein coupled receptors and modulators thereof. International Patent 2003; WO 01/38533 A2.
8. Larsen M, Burton K, Zantello M et al. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells. Biochem Biophys Res Comm 2001; 286: 895-901. (Pubitemid 32926749)
9. Kubiak T, Larsen M, Nulf S et al. Differential activation of "social" and "solitary" variants of the Caenorhabditis elegans G-protein coupled receptor NPR-1 by its cognate ligand AF9. J Biol Chem 2003; 278(36): 33724-33729. (Pubitemid 37553205)
10. Kubiak T, Larsen M, Zantell M et al. Functional annotation of the putative orphan Caenorhabditis elegans G-protein coupled receptor C10C6.2 as a FLP15 peptide receptor. J Biol Chem 2003; 278(43); 42115-42120. (Pubitemid 37310478)
11. Minic J, Sautel M, Salesse R et al. Yeast system as a screening tool for pharmacological assessment of G-protein coupled receptors. Curr Med Chem 2005; 12: 961-969. (Pubitemid 40443850)
12. Thomsen W, Frazer J, Unett D. Functional assays for screening GPCR targets. Curr Opin Biotech 2005; 16:655-665. (Pubitemid 41654645)
13. Mertens I, Vandingeen A, Meeuen T et al. Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans. FEBS Lett 2004; 573:55-60. (Pubitemid 39141035)
14. Birse R, Johnson E, Taghert P et al. Widely distributed Drosophila G-protein coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. J Neurobiol 2005; 66:33-46. (Pubitemid 41829026)
15. Cismowski M, Takesono A, Ma C et al. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signalling. Nat Biotech 1999; 17(9):878-883. (Pubitemid 29416661)
16. Wang Z, Broach J, Peiper S. Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4. Meth Mol Biol 2006; 332:115-127.
17. Wolcke J, Ullmann D. Miniaturized HTS technologies-uHTS. Drug Discov Today 2001; 6(12):637-646.
18. Sittampalam G, Kahl S, Janzen W. High-throughput screening: advances in assay technologies. Curr Opin Chem Biol 1997; 1:384-391. (Pubitemid 127437166)
19. Kenny B, Bushfield M, Parry-Smith D et al. The application of high-throughput screening to novel lead discovery. Prog Drug Res 1998; 51:245-269. (Pubitemid 28511546)
20. Macarron R, Hertzberg R. Design and implementation of high throughput screening assays. Meth Mol Biol 2002; 190:1-29.
21. Gribbon P, Lyons R, Laflin P et al. Evaluating real-life high-throughput screening data. J Biomol Screen 2005; 10(2):99-107.
22. Terrett NK, Gardner M, Gordon DW et al. Combinatorial synthesis-the design of compound libraries and their application to drug discovery. Tetrahedron 1995; 51(30):8135-8173.
23. Feher M, Schmidt JM. Property distributions: differences between drugs, natural products and molecules from combinatorial chemistry. J Chem Inf Comput Sci 2003; 43:218-22.
24. Becker OM, Shacham S, Marantz Y et al. Modeling the 3D structure of GPCRs: advances and applications to drug discovery. Curr Opin Drug Discov Devel 2003; 6(3):353-361. (Pubitemid 36702308)
25. Becker OM, Marantz Y, Shacham S et al. G-protein coupled receptors: in silico drug discovery in 3D. PNAS 2004; 101(31) :11304-11309.
26. Lipinski CA, Lombardo F, Dominy BW et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Delivery Rev 1997; 23(1-3):3-25. (Pubitemid 27046991)
27. Hopkins AL, Groom CR. The druggable genome. Nat Rev Drug Discov 2002; 1(9):727-730. (Pubitemid 37361545)
28. Walter M. From serendipity to design-making agrochemicals to order. Pesticide Outlook 2003; 14:27-31.
29. Gilleard JS, Woods DJ, Dow JAT. Model organism genomics in veterinary parasite drug discovery. Trends Parasitol 2005; 21(7):302-305. (Pubitemid 40807172)