Millisecond dynamics in glutaredoxin during catalytic turnover is dependent on substrate binding and absent in the resting states

Journal of the American Chemical Society

Volumn 133, Issue 9, 2011, Pages 3034-3042

  Jensen, Kristine Steen ^a,b   Winther, Jakob R ^a   Teilum, Kaare ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC EFFICIENCIES; CATALYTIC TURNOVER; COMPETITIVE INHIBITION; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; CONFORMATIONAL TRANSITIONS; ENCOUNTER COMPLEX; ENZYME FUNCTIONS; EXCHANGE RATES; EXCHANGE REACTION; GLUTATHIONES; INDUCED-FIT MECHANISM; MAGNETIZATION TRANSFER; NUCLEAR SPIN RELAXATION; PROTEIN BACKBONE; REDUCED GLUTATHIONE; REDUCED-STATE; RELAXATION DISPERSION; RESTING STATE; SUBSTRATE BINDING; TIME-SCALES; TURNOVER RATE; TWO-STATE;

CATALYSIS; CATALYSTS; DISPERSIONS; DYNAMICS; ENZYMES; NUCLEAR MAGNETIC RESONANCE; REACTION INTERMEDIATES; REACTION KINETICS; TITRATION;

ENZYME INHIBITION;

GLUTAREDOXIN; GLUTATHIONE;

ARTICLE; CATALYSIS; CATALYST; CONFORMATIONAL TRANSITION; DYNAMICS; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; KINETICS; MOTION; TIME;

CATALYSIS; GLUTAREDOXINS; GLUTATHIONE; HUMANS; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 79952259946     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1096539     Document Type: Article

References (35)

1. Teilum, K.; Olsen, J. G.; Kragelund, B. B. Cell. Mol. Life Sci. 2009, 66, 2231-2247
2. Wolf-Watz, M.; Thai, V.; Henzler-Wildman, K.; Hadjipavlou, G.; Eisenmesser, E. Z.; Kern, D. Nat. Struct. Mol. Biol. 2004, 11, 945-949
3. Doucet, N.; Watt, E. D.; Loria, J. P. Biochemistry 2009, 48, 7160-7168
4. Kovrigin, E. L.; Loria, J. P. J. Am. Chem. Soc. 2006, 128, 7724-7725
5. Schwartz, S. D.; Schramm, V. L. Nat. Chem. Biol. 2009, 5, 551-558
6. Kovrigin, E. L.; Loria, J. P. Biochemistry 2006, 45, 2636-2647
7. Boehr, D. D.; McElheny, D.; Dyson, H. J.; Wright, P. E. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 1373-1378
8. Boehr, D. D.; McElheny, D.; Dyson, H. J.; Wright, P. E. Science 2006, 313, 1638-1642
9. Palmer, A. G., III; Kroenke, C. D.; Loria, J. P. Methods Enzymol. 2001, 339, 204-238
10. Kern, D.; Eisenmesser, E. Z.; Wolf-Watz, M. Methods Enzymol. 2005, 394, 507-524
11. Eisenmesser, E. Z.; Millet, O.; Labeikovsky, W.; Korzhnev, D. M.; Wolf-Watz, M.; Bosco, D. A.; Skalicky, J. J.; Kay, L. E.; Kern, D. Nature 2005, 438, 117-121
12. Eisenmesser, E. Z.; Bosco, D. A.; Akke, M.; Kern, D. Science 2002, 295, 1520-1523
13. Henzler-Wildman, K. A.; Thai, V.; Lei, M.; Ott, M.; Wolf-Watz, M.; Fenn, T.; Pozharski, E.; Wilson, M. A.; Petsko, G. A.; Karplus, M.; Hubner, C. G.; Kern, D. Nature 2007, 450, 838-844
14. Henzler-Wildman, K. A.; Lei, M.; Thai, V.; Kerns, S. J.; Karplus, M.; Kern, D. Nature 2007, 450, 913-916
15. Labeikovsky, W.; Eisenmesser, E. Z.; Bosco, D. A.; Kern, D. J. Mol. Biol. 2007, 367, 1370-1381
16. Grunberg, R.; Leckner, J.; Nilges, M. Structure 2004, 12, 2125-2136
17. Koshland, D. E. Proc. Natl. Acad. Sci. U.S.A 1958, 44, 98-104
18. Boehr, D. D.; Nussinov, R.; Wright, P. E. Nat. Chem. Biol. 2009, 5, 789-796
19. Csermely, P.; Palotai, R.; Nussinov, R. Trends Biochem. Sci. 2010, 35, 539-546
20. Lillig, C. H.; Berndt, C.; Holmgren, A. Biochim. Biophys. Acta 2008, 1780, 1304-1317
21. Yang, Y.; Jao, S.; Nanduri, S.; Starke, D. W.; Mieyal, J. J.; Qin, J. Biochemistry 1998, 37, 17145-17156
22. Srinivasan, U.; Mieyal, P. A.; Mieyal, J. J. Biochemistry 1997, 36, 3199-3206
23. Jensen, K. S.; Hansen, R. E.; Winther, J. R. Antioxid. Redox. Signal. 2009, 11, 1047-1058
24. Delaglio, F.; Grzesiek, S.; Vuister, G. W.; Zhu, G.; Pfeifer, J.; Bax, A. J. Biomol. NMR 1995, 6, 277-293
25. Sun, C.; Holmgren, A.; Bushweller, J. H. Protein Sci. 1997, 6, 383-390
26. Robinson, G.; Kuchel, P. W.; Chapman, B. E.; Doddrell, D. M.; Irving, M. G. J. Magn. Reson. 1985, 63, 314-319
27. Loria, J. P.; Rance, M.; Palmer, A. G. J. Am. Chem. Soc. 1999, 121, 2331-2332
28. Tollinger, M.; Skrynnikov, N. R.; Mulder, F. A.; Forman-Kay, J. D.; Kay, L. E. J. Am. Chem. Soc. 2001, 123, 11341-11352
29. Iversen, R.; Andersen, P. A.; Jensen, K. S.; Winther, J. R.; Sigurskjold, B. W. Biochemistry 2010, 49, 810-820
30. Led, J. J.; Gesmar, H.; Abildgaard, F. Methods Enzymol. 1989, 176, 311-329
31. Rabenstein, D. L.; Millis, K. K. Biochim. Biophys. Acta 1995, 1249, 29-36
32. Millet, O.; Loria, J. P.; Kroenke, C. D.; Pons, M.; Palmer, A. G. J. Am. Chem. Soc. 2000, 122, 2867-2877
33. Beach, H.; Cole, R.; Gill, M. L.; Loria, J. P. J. Am. Chem. Soc. 2005, 127, 9167-9176
34. Kelley, J. J., III; Caputo, T. M.; Eaton, S. F.; Laue, T. M.; Bushweller, J. H. Biochemistry 1997, 36, 5029-5044
35. Brath, U.; Akke, M. J. Mol. Biol. 2009, 387, 233-244