Membrane environment exerts an important influence on Rac-mediated activation of phospholipase Cγ2

Molecular and Cellular Biology

Volumn 31, Issue 6, 2011, Pages 1240-1251

  Everett, Katy L ^a   Buehler, Anja ^b   Bunney, Tom D ^a   Margineanu, Anca ^c   Baxendale, Rhona W ^a   Vatter, Petra ^b   Retlich, Michael ^b   Walliser, Claudia ^b   Manning, Hugh B ^c   Neil, Mark A A ^c   Dunsby, Christopher ^c   French, Paul M W ^c   Gierschik, Peter ^b   Katan, Matilda ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C GAMMA2; RAC2 PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; LIPID MEMBRANE; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; HUMANS; PHOSPHOLIPASE C GAMMA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RAC GTP-BINDING PROTEINS;

EID: 79952256065     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01408-10     Document Type: Article

References (43)

1. Albertazzi, L., D. Arosio, L. Marchetti, F. Ricci, and F. Beltram. 2009. Quantitative FRET analysis with the EGFP-mCherry fluorescent protein pair. Photochem. Photobiol. 85:287-297.
2. Borst, J. W., et al. 2008. Structural changes of yellow Cameleon domains observed by quantitative FRET analysis and polarized fluorescence correlation spectroscopy. Biophys. J. 95:5399-5411.
3. Bunney, T. D., and M. Katan. 24 September 2010. PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem. Sci. [Epub ahead of print.] doi:10.1016/j.tibs.2010.08.003.
4. Bunney, T. D., et al. 2009. Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. Mol. Cell 34:223-233.
5. Carpenter, G., and Q. Ji. 1999. Phospholipase C-gamma as a signal-transducing element. Exp. Cell Res. 253:15-24.
6. Cole, C., J. D. Barber, and G. J. Barton. 2008. The Jpred 3 secondary structure prediction server. Nucleic Acids Res. 36:W197-W201.
7. Cremasco, V., et al. 2010. Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One 5:e8909.
8. DeBell, K., et al. 2007. Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain. Mol. Cell. Biol. 27:854-863.
9. Ellis, M. V., et al. 1998. Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1. J. Biol. Chem. 273:11650-11659.
10. Essen, L. O., O. Perisic, R. Cheung, M. Katan, and R. L. Williams. 1996. Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Nature 380:595-602.
11. Everett, K. L., et al. 2009. Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J. Biol. Chem. 284:23083-23093.
12. Gresset, A., S. N. Hicks, T. K. Harden, and J. Sondek. 2010. Mechanism of phosphorylation-induced activation of phospholipase C-{gamma} isozymes. J. Biol. Chem. 285:35836-35847.
13. Groves, J. T., and J. Kuriyan. 2010. Molecular mechanisms in signal transduction at the membrane. Nat. Struct. Mol. Biol. 17:659-665.
14. Guidetti, G. F., et al. 2009. Integrin alpha2beta1 induces phosphorylation-dependent and phosphorylation-independent activation of phospholipase Cgamma2 in platelets: role of Src kinase and Rac GTPase. J. Thromb. Haemost. 7:1200-1206.
15. Gutman, O., C. Walliser, T. Piechulek, P. Gierschik, and Y. I. Henis. 2010. Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. J. Biol. Chem. 285:3905-3915.
16. Harden, T. K., S. N. Hicks, and J. Sondek. 2009. Phospholipase C isozymes as effectors of Ras superfamily GTPases. J. Lipid Res. 50(Suppl.):S243-S248.
17. Hicks, S. N., et al. 2008. General and versatile autoinhibition of PLC isozymes. Mol. Cell 31:383-394.
18. Homma, M. K., M. Yamasaki, S. Ohmi, and Y. Homma. 1997. Inhibition of phosphoinositide hydrolysis and cell growth of Swiss 3T3 cells by myristoylated phospholipase C inhibitor peptides. J. Biochem. 122:738-742. (Pubitemid 27474942)
19. Homma, Y., and T. Takenawa. 1992. Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region. J. Biol. Chem. 267:21844-21849.
20. Horstman, D. A., K. DeStefano, and G. Carpenter. 1996. Enhanced phospholipase C-gamma1 activity produced by association of independently expressed X and Y domain polypeptides. Proc. Natl. Acad. Sci. U. S. A. 93:7518-7521.
21. Jezyk, M. R., et al. 2006. Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nat. Struct. Mol. Biol. 13:1135-1140.
22. Katan, M. 2005. New insights into the families of PLC enzymes: looking back and going forward. Biochem. J. 391:e7-e9.
23. Katan, M., R. Rodriguez, M. Matsuda, Y. M. Newbatt, and G. W. Aherne. 2003. Structural and mechanistic aspects of phospholipase Cgamma regulation. Adv. Enzyme Regul. 43:77-85.
24. Lakowicz, J. R. 2006. Principles of fluorescence spectroscopy, 3rd ed. Springer, New York, NY.
25. Manning, H. B., et al. 2008. A compact, multidimensional spectrofluorometer exploiting supercontinuum generation. J. Biophotonics 1:494-505.
26. Matsuda, M., et al. 2001. Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor. J. Cell Biol. 153:599-612. (Pubitemid 34280145)
27. Merzlyak, E. M., et al. 2007. Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat. Methods 4:555-557. (Pubitemid 47214772)
28. Phillips, R., T. Ursell, P. Wiggins, and P. Sens. 2009. Emerging roles for lipids in shaping membrane-protein function. Nature 459:379-385.
29. Piechulek, T., et al. 2005. Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J. Biol. Chem. 280:38923-38931.
30. Pleines, I., et al. 2009. Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch. 457:1173-1185.
31. Poulin, B., F. Sekiya, and S. G. Rhee. 2005. Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1. Proc. Natl. Acad. Sci. U. S. A. 102:4276-4281.
32. Rodriguez, R., et al. 2001. Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J. Biol. Chem. 276:47982-47992.
33. Shcherbo, D., et al. 2009. Practical and reliable FRET/FLIM pair of fluorescent proteins. BMC Biotechnol. 9:24.
34. Sorli, S. C., T. D. Bunney, P. H. Sugden, H. F. Paterson, and M. Katan. 2005. Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants. Oncogene 24:90-100. (Pubitemid 40143868)
35. Stahelin, R. V., and W. Cho. 2001. Differential roles of ionic, aliphatic, and aromatic residues in membrane-protein interactions: a surface plasmon resonance study on phospholipases A2. Biochemistry 40:4672-4678. (Pubitemid 32374655)
36. Suh, P. G., et al. 2008. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41:415-434.
37. Sultzman, L., C. Ellis, L. L. Lin, T. Pawson, and J. Knopf. 1991. Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2. Mol. Cell. Biol. 11:2018-2025.
38. Visser, A. J., et al. 2010. Time-resolved FRET fluorescence spectroscopy of visible fluorescent protein pairs. Eur. Biophys. J. 39:241-253.
39. Volkmer, A., V. Subramaniam, D. J. Birch, and T. M. Jovin. 2000. One- and two-photon excited fluorescence lifetimes and anisotropy decays of green fluorescent proteins. Biophys. J. 78:1589-1598.
40. Walliser, C., et al. 2008. rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J. Biol. Chem. 283:30351-30362.
41. Wu, B., Y. Chen, and J. D. Muller. 2009. Fluorescence fluctuation spectroscopy of mCherry in living cells. Biophys. J. 96:2391-2404.
42. Zhao, L., and P. K. Vogt. 2008. Class I PI3K in oncogenic cellular transformation. Oncogene 27:5486-5496.
43. Zhao, L., and P. K. Vogt. 2008. Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc. Natl. Acad. Sci. U. S. A. 105:2652-2657.