Determination of 3′,4′,5′,5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection

Biomedical Chromatography

Volumn 23, Issue 4, 2009, Pages 335-339

  Cai, Hong ^a   Brown, Karen ^a   Steward, William P ^a   Gescher, Andreas J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

3 ,4 ,5 ,5 7 pentamethoxyflavone; Cancer chemoprevention; High performance liquid chromatography

Indexed keywords

MAMMALS;

3′,4′,5′,5′7-PENTAMETHOXYFLAVONE; CANCER CHEMOPREVENTION; CONDITION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC ANALYSIS; HPLC METHOD; INTESTINAL MUCOSA; MEASUREMENTS OF; MICE PLASMA; UV DETECTION;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

3',4',5',5',7 PENTAMETHOXYFLAVONE; FLAVONE; FLAVONE DERIVATIVE; ORGANIC SOLVENT; PROTEIN; TRICIN; UNCLASSIFIED DRUG; 5,7,3',4',5' PENTAMETHOXYFLAVONE; 5,7,3',4',5'-PENTAMETHOXYFLAVONE; FLAVONOID;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE MUCOSA; MOUSE; NONHUMAN; PRECIPITATION; SOLID PHASE EXTRACTION; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; FEEDING BEHAVIOR; HUMAN; METHODOLOGY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

MUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; FOOD HABITS; HUMANS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; SENSITIVITY AND SPECIFICITY;

EID: 65249118879     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1120     Document Type: Article

References (10)

1. Cai H, Steward WP and Gescher AJ. Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV-visible detection. Biomedical Chromatography. 2005a; 19: 518-522.
2. Min mice. Molecular Cancer Therapy 2005b; 4: 1287-1292.
3. Cai H, Boocock DJ, Steward WP and Gescher AJ. Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. Cancer Chemotherapy and Pharmacology 2007; 60: 257-266.
4. min/+ mice by green tea polyphenols (Polyphenon E) and individual catechins. Nutrition and Cancer 2007; 59: 62-69.
5. Kinoshita T and Firman K. Myricetin 5,7,3′,4′,5′-pentamethyl ether and other methylated flavonoids from Murraya paniculata. Phytochemistry 1997; 45: 179-181.
6. Lamaritiniere CA, Zhang JX and Cotroneo MS. Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. American Journal of Clinical Nutrition 1998; 68: 1400S-1405S.
7. Shukla S, MacLennan GT, Flask CA, Fu P, Mishra A, Resnick MI and Gupta S. Blockade of β-catenin signalling by plant flavonoids apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Research 2007; 14: 6925-6935.
8. Tomazela DM, Pupo MT, Passador EAP, da Silva MF, Vieira PC, Fernandes JB, Fo ER, Oliva G and Pirani JR. Pyrano chalcones and a flavone from Neoraputia mangnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. Phytochemistry. 2000; 55: 643-651.
9. Walle UK and Walle T. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. Drug Metabolism and Disposition 2007; 35: 1985-1989.
10. Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T and Wallace J. United Kingdom Coordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). British Journal of Cancer 1998; 77: 1-30.