HSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

Nucleic Acids Research

Volumn 39, Issue 5, 2011, Pages 1692-1702

  Richard, Derek J ^a   Savage, Kienan ^a   Bolderson, Emma ^a   Cubeddu, Liza ^c   So, Sairei ^d   Ghita, Mihaela ^b   Chen, David J ^d   White, Malcolm F ^e   Richard, Kerry ^f   Prise, Kevin M ^b   Schettino, Giuseppe ^b   Khanna, Kum Kum ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF ST ANDREWS   (United Kingdom)

^f ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HSSB1 PROTEIN; SINGLE STRANDED DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; INTERPHASE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

CELL CYCLE PROTEINS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HUMANS; NUCLEAR PROTEINS; RADIATION, IONIZING;

EID: 79952233616     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq1098     Document Type: Article

References (33)

1. Lieber M.R. (2008) The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283 1-5.
2. Saleh-Gohari N. and Helleday T. (2004) Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res. 32 3683-3688. (Pubitemid 39157716)
3. Saintigny Y. Delacote F. Boucher D. Averbeck D. and Lopez B.S. (2007) XRCC4 in G1 suppresses homologous recombination in S/G2 in G1 checkpoint-defective cells. Oncogene 26 2769-2780. (Pubitemid 46663830)
4. Lee J.H. and Paull T.T. (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 551-554. (Pubitemid 40570585)
5. D'Amours D. and Jackson S.P. (2002) The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell. Biol. 3 317-327. (Pubitemid 34619266)
6. Rass E. Grabarz A. Plo I. Gautier J. Bertrand P. and Lopez B.S. (2009) Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat. Struct. Mol. Biol. 16 819-824.
7. Xie A. Kwok A. and Scully R. (2009) Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat. Struct. Mol. Biol. 16 814-818.
8. Iftode C. Daniely Y. and Borowiec J.A. (1999) Replication protein A (RPA): the eukaryotic SSB. Crit. Rev. Biochem Mol. Biol. 34 141-180. (Pubitemid 29326003)
9. Wold M.S. (1997) Replication protein A: a heterotrimeric single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66 61-92. (Pubitemid 27274652)
10. Zou Y. Liu Y. Wu X. and Shell S.M. (2006) Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J. Cell. Physiol. 208 267-273. (Pubitemid 43993416)
11. Richard D.J. Bolderson E. Cubeddu L. Wadsworth R.I. Savage K. Sharma G.G. Nicolette M.L. Tsvetanov S. McIlwraith M.J. Pandita R.K. et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453 677-681. (Pubitemid 351769294)
12. Richard D.J. Bolderson E. and Khanna K.K. (2009) Multiple human single-stranded DNA binding proteins function in genome maintenance: structural biochemical and functional analysis. Crit. Rev. Biochem. Mol. Biol. 1-19.
13. Wadsworth R.I. and White M.F. (2001) Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus. Nucleic Acids Res. 29 914-920. (Pubitemid 32162259)
14. Skaar J.R. Richard D.J. Saraf A. Toschi A. Bolderson E. Florens L. Washburn M.P. Khanna K.K. and Pagano M. (2009) INTS3 controls the hSSB1-mediated DNA damage response. J. Cell. Biol. 187 25-32.
15. Li Y. Bolderson E. Kumar R. Muniandy P.A. Xue Y. Richard D. Seidman M. Pandita T.K. Khanna K.K. and Wang W. (2009) hSSB1 and hSSB2 form similar multi-protein complexes that participate in DNA damage response. J. Biol. Chem. 284 23525-23531.
16. Dupre A. Boyer-Chatenet L. and Gautier J. (2006) Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat. Struct. Mol. Biol. 13 451-457. (Pubitemid 43881586)
17. Lee J.H. and Paull T.T. (2004) Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304 93-96. (Pubitemid 38451463)
18. Uematsu N. Weterings E. Yano K. Morotomi-Yano K. Jakob B. Taucher-Scholz G. Mari P.O. van Gent D.C. Chen B.P. and Chen D.J. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J. Cell. Biol. 177 219-229. (Pubitemid 46658634)
19. Prise K.M. Schettino G. Vojnovic B. Belyakov O. and Shao C. (2009) Microbeam studies of the bystander response. J. Radiat. Res. 50(Suppl. A) A1-A6.
20. Huang J. Gong Z. Ghosal G. and Chen J. (2009) SOSS complexes participate in the maintenance of genomic stability. Mol. Cell 35 384-393.
21. Li Y. Bolderson E. Kumar R. Muniandy P.A. Xue Y. Richard D.J. Seidman M. Pandita T.K. Khanna K.K. and Wang W. (2009) HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J. Biol. Chem. 284 23525-23531.
22. Baillat D. Hakimi M.A. Naar A.M. Shilatifard A. Cooch N. and Shiekhattar R. (2005) Integrator a multiprotein mediator of small nuclear RNA processing associates with the C-terminal repeat of RNA polymerase II. Cell 123 265-276. (Pubitemid 41457216)
23. Paull T.T. Rogakou E.P. Yamazaki V. Kirchgessner C.U. Gellert M. and Bonner W.M. (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10 886-895. (Pubitemid 30647617)
24. Tomimatsu N. Mukherjee B. and Burma S. (2009) Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep. 10 629-635.
25. Bolderson E. Tomimatsu N. Richard D.J. Boucher D. Kumar R. Pandita T.K. Burma S. and Khanna K.K. (2010) Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 38 1821-1831.
26. Delia D. Piane M. Buscemi G. Savio C. Palmeri S. Lulli P. Carlessi L. Fontanella E. and Chessa L. (2004) MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Hum. Mol. Genet. 13 2155-2163. (Pubitemid 39377837)
27. Gatei M. Young D. Cerosaletti K.M. Desai-Mehta A. Spring K. Kozlov S. Lavin M.F. Gatti R.A. Concannon P. and Khanna K. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25 115-119. (Pubitemid 30257049)
28. Cubeddu L. and White M.F. (2005) DNA damage detection by an archaeal single-stranded DNA-binding protein. J. Mol. Biol. 353 507-516. (Pubitemid 41414730)
29. Zou L. and Elledge S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 1542-1548. (Pubitemid 36682880)
30. Sartori A.A. Lukas C. Coates J. Mistrik M. Fu S. Bartek J. Baer R. Lukas J. and Jackson S.P. (2007) Human CtIP promotes DNA end resection. Nature 450 509-514. (Pubitemid 350190253)
31. Raderschall E. Golub E.I. and Haaf T. (1999) Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc. Natl Acad. Sci. USA 96 1921-1926. (Pubitemid 29117843)
32. Schlegel B.P. Jodelka F.M. and Nunez R. (2006) BRCA1 promotes induction of ssDNA by ionizing radiation. Cancer Res. 66 5181-5189. (Pubitemid 43844941)
33. West S.C. (2003) Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell. Biol. 4 435-445. (Pubitemid 36648589)