Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population

Journal of Neuro-Oncology

Volumn 100, Issue 2, 2010, Pages 187-192

  Kurzwelly, Delia ^a   Knop, Stefan ^b   Guenther, Markus ^c   Loeffler, Juergen ^b   Korfel, Agnieszka ^d   Thiel, Eckhard ^d   Hebart, Holger ^e   Simon, Matthias ^a   Weller, Michael ^f   Linnebank, Michael ^f   Herrlinger, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c KLINIKUM STUTTGART   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e Klinikum Schwaebisch Gmuend Stauferklinik   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

DNA methylation; Folate; Genetic polymorphism; Methionine; PCNSL

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; METHIONINE; THYMIDYLATE SYNTHASE; TRANSCOBALAMIN II;

ADULT; AGED; ALLELE; AMINO ACID METABOLISM; ARTICLE; CANCER INCIDENCE; CONTROLLED STUDY; FEMALE; FOLATE METABOLISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; POPULATION GENETICS; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; RETROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; CENTRAL NERVOUS SYSTEM NEOPLASMS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HUMANS; INCIDENCE; LYMPHOMA; MALE; METHIONINE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79952193944     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0154-4     Document Type: Article

References (24)

1. Montesinos-Rongen M, Küppers R, Schlüter D, Spieker T, Van Roost D, Schaller C, Reifenberger G, Wiestler OD, Deckert-Schlüter M (1999) Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. Am J Pathol 155:2077-2086
2. Kurzwelly D, Müller CA, Korfel A, Thiel E, Linnebank M, Weller M, Herrlinger U (2008) Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients. J Neurooncol 90:53-55
3. Weber T, Weber RG, Kaulich K, Actor B, Meyer-Puttlitz B, Lampel S, Büschges R, Weigel R, Deckert-Schlüter M, Schmiedek P, Reifenberger G, Lichter P (2000) Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. Brain Pathol 10:73-84 (Pubitemid 30056395)
4. Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159:423-443 (Pubitemid 38280289)
5. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 96:12810-12815 (Pubitemid 29513584)
6. Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, Kondoh E, Maeda S, Asakura S, Kaba S, Nakamura S, Seto M, Morishima Y, Tajima K (2001) Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 97:3205-3209
7. Ma J, Stampfer MJ, Christensen B, Giovannucci E, Hunter DJ, Chen J, Willett WC, Selhub J, Hennekens CH, Gravel R, Rozen R (1999) A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocysteine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 8:825-829 (Pubitemid 29445020)
8. Lincz LF, Scorgie FE, Kerridge I, Potts R, Spencer A, Enno A (2003) Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma. Br J Haematol 120:1051-1054 (Pubitemid 36411565)
9. Linnebank M, Schmidt S, Kölsch H, Linnebank A, Heun R, Schmidt-Wolf IG, Glasmacher A, Fliessbach K, Klockgether T, Schlegel U, Pels H (2004) The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma. Br J Cancer 90:1969-1971 (Pubitemid 38746338)
10. Semmler A, Simon M, Moskau S, Linnebank M (2006) The methionine synthase polymorphism c.2756A > G alters susceptibility to glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 15:2314-2316
11. Semmler A, Simon M, Moskau S, Linnebank M (2008) Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation. J Neurosurg 108:999-1004 (Pubitemid 351656849)
12. Moskau S, Golla A, Grothe C, Boes M, Pohl C, Klockgether T (2005) Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families. Stroke 36:5-8 (Pubitemid 40054167)
13. Linnebank M, Moskau S, Farmand S, Fliessbach K, Kölsch H, Bös M, Grothe C, Becker D, Harbrecht U, Pohl C, Wüllner U, Klockgether T (2006) Homocysteine and carotid intima-media thickness in a German population: lack of clinical relevance. Stroke 37:2840-2842 (Pubitemid 44922549)
14. Afman LA, Lievers KJ, van der Put NM, Trijbels FJ, Blom HJ (2002) Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet 10:433-438
15. Harmon DL, Shields DC, Woodside JV, McMaster D, Yarnell JW, Young IS, Peng K, Shane B, Evans AE, Whitehead AS (1999) Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 17:298-309 (Pubitemid 29522203)
16. Linnebank M, Homberger A, Junker R, Nowak-Goettl U, Harms E, Koch HG (2001) High prevalence of the I278T mutation of the human cystathionine β-synthase detected by a novel screening application. Thromb Haemost 85:986-988 (Pubitemid 32573747)
17. Johnson WG, Stenroos ES, Spychala JR, Chatkupt S, Ming SX, Buyske S (2004) New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet A 124:339-345
18. Winkelmayer WC, Eberle C, Sunder-Plassmann G, Fodinger M (2003) Effects of the glutamate carboxypeptidase II (GCP2 1561C > T) and the reduced folate carrier (RFC1 80G > A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 63:2280-2285 (Pubitemid 36605843)
19. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113
20. van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62:1044-1051
21. Linnebank M, Fliessbach K, Kolsch H, Rietschel M, Wullner U (2005) The methionine synthase polymorphism c.2756A > G (D919G) is relevant for disease-free longevity. Int J Mol Med 16:759-761
22. Linnebank M, Homberger A, Nowak-Gottl U, Marquardt T, Harms E, Koch HG (2000) Linkage disequilibrium of the common mutations 677C > T and 1298A > C of the human methylenetetrahydrofolate reductase gene as proven by the novel polymorphisms 129C > T, 1068C > T. Eur J Pediatr 159:472-473 (Pubitemid 30329117)
23. Henao OL, Piyathilake CJ, Waterbor JW, Funkhouser E, Johanning GL, Heimburger DC, Partridge EE (2005) Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. Int J Cancer 113:991-997 (Pubitemid 40096879)
24. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF, United Kingdom Childhood Cancer Study investigators (2001) Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 98:4004-4009 (Pubitemid 32249888)