Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type

Brain Pathology

Volumn 10, Issue 1, 2000, Pages 73-84

  Weber, Tillmann ^a,b   Weber, Ruthild G ^a,d   Kaulich, Kerstin ^c   Actor, Bertrand ^a   Meyer Puttlitz, Birgit ^c   Lampel, Stefan ^a   Buschiges, Rainer ^c   Weigel, Ralf ^b   Deckert Schlüter, Martina ^c   Schmiedek, Peter ^b   Reifenberger, Guido ^c   Lichter, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

ADULT; ARTICLE; B CELL LYMPHOMA; CENTRAL NERVOUS SYSTEM TUMOR; CHROMOSOME 11Q; CHROMOSOME 12P; CHROMOSOME 12Q; CHROMOSOME 16P; CHROMOSOME 17Q; CHROMOSOME 18Q; CHROMOSOME 1P; CHROMOSOME 1Q; CHROMOSOME 22Q; CHROMOSOME 6Q; CHROMOSOME 9P; CHROMOSOME 9Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MALE;

EID: 12944328014     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2000.tb00244.x     Document Type: Article

References (61)

1. Antinori A, Larocca LM, Fassone L, Cattani P, Capello D, Cingolani A, Saglio G, Fadda G, Gaidano G, Ortona L (1999) HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma. Brain Pathol 9:199-208
2. Avet-Loiseau H, Vigier M, Moreau A, Mellerin MP, Gaillard F, Harousseau JL, Bataille R, Milpied N (1997) Comparative genomic hybridization detects genomic abnormalities in 80% of follicular lymphomas. Br J Haematol 97: 119-122
3. Barth TF, Döhner H, Werner CA, Stilgenbauer S, Schlotter M, Pawlita M, Lichter P, Möller P, Bentz M (1998) Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract. Blood 91: 4321-4330
4. Bentz M, Plesch A, Stilgenbauer S, Döhner H, Lichter P (1998) Minimal size of deletions detected by comparative genomic hybridization. Genes Chromosom Cancer 21: 172-175
5. Bentz M, Werner CA, Döhner H, Joos S, Barth TFE, Siebert R, Schröder M, Stilgenbauer S, Fischer K, Möller P, Lichter P (1996) High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma. Blood 88: 1437-1444
6. Chan WY, Wong N, Chan AB, Chow JH, Lee JC (1998) Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach. Am J Pathol 152: 11-16
7. Cobbers JM, Wolter M, Reifenberger J, Ring GU, Jessen F, An HX, Niederacher D, Schmidt EE, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis DN, Collins VP, Reifenberger G (1998) Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL. Brain Pathol 8: 263-276
8. Corboy JR, Garl PJ, Kleinschmidt-DeMasters BK (1998) Human herpesvirus 8 DNA in CNS lymphomas from patients with and without AIDS. Neurology 50: 335-340
9. Cote TR, Manns A, Hardy CR, Yellin FJ, Hartge P (1996) Epidemiology ot brain lymphoma among people with or without acquired immunodeficiency syndrome. AIDS/Cancer Study Group. J Natl Cancer Inst 88: 675-679
10. DeAngelis LM (1991) Primary central nervous system lymphoma: a new clinical challenge. Neurology 41: 619-621
11. Deckert-Schluter M, Rang A, Wiestler OD (1998) Apoptosis and apoptosis-related gene products in primary non-Hodgkin's lymphoma of the central nervous system. Acta Neuropathol (Berl) 96: 157-162
12. Dierlamm J, Rosenberg C, Stul M, Pittaluga S, Wlodarska I, Michaux L, Dehaen M, Verhoef G, Thomas J, de Kelver W, Bakker-Schut T, Cassiman JJ, Raap AK, De Wolf-Peeters C, Van den Berghe H, Hagemeijer A (1997) Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia 11: 747-758
13. Du Manoir S, Schröck E, Bentz M, Speicher MR, Joos S, Ried T, Lichter P, Cremer T (1995) Quantitative analysis of comparative genomic hybridization. Cytometry 19: 27-41
14. Du Manoir S, Speicher MR, Joos S, Schröck E, Popp S, Döhner H, Kovacs G, Robert-Nicoud M, Lichter P, Cremer T (1993) Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet 90: 590-610
15. Eby NL, Grufferman S, Flannelly CM, Schold SCJ, Vogel FS, Burger PC (1988) Increasing incidence of primary brain lymphoma in the US. Cancer 62: 2461-2465
16. Gaidano G, Capello D, Pastore C, Antinori A, Gloghini A, Carbone A, Larocca LM, Saglio G (1997) Analysis of human herpesvirus type 8 infection in AIDS-related and AIDS-unrelated primary central nervous system lymphoma. J Infect Dis 175: 1193-1197
17. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, de Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Müller-Hermelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA (1994) A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group. Blood 84: 1361-1392
18. Hatta Y, Yamada Y, Tomonaga M, Miyoshi I, Said JW, Koeffler HP (1999) Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia. Blood 93: 613-
19. Ichimura K, Schmidt EE, Goike HM, Collins VP (1996) Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene 13: 1065-1072
20. Itoyama T, Sadamori N, Tsutsumi K, Tokunaga Y, Soda H, Tomonaga M, Yamamori S, Masuda Y, Oshima K, Kikuchi M (1994) Primary central nervous system lymphomas Immunophenotypic, virologic, and cytogenetic findings of three patients without immune defects. Cancer 73: 455-463
21. Jellinger KA, Paulus W (1995) Primary central nervous system lymphomas - new pathological developments. J Neurooncol 24: 33-36
22. Joos S, Otano-Joos MI, Ziegler S, Brüderlein S, du Manoir S, Bentz M, Möller P, Lichter P (1996) Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood 87: 1571-1578
23. Joos S, Scherthan H, Speicher MR, Schlegel J, Cremer T, Lichter P (1993) Detection of amplified genomic sequences by reverse chromosome painting using genomic tumor DNA as probe. Hum Genet 90: 584-589
24. Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258: 818-821
25. Kallioniemi O-P, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW, Pinkel D (1994) Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosom. Cancer 10: 231-243
26. Kramer MHH, Hermans E, Wijburg K, Philippe E, Geelen E, van Krieken JHJM, de Jong D, Maartense E, Schuuring E, Kluin PM (1998) Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood 9: 3152-3162
27. Kuukasjarvi T, Tanner M, Pennanen S, Karhu R, Kallioniemi O-P, Isola J (1997) Genetic changes in intraductal breast cancer detected by comparative genomic hybridization. Am J Pathol 150: 1465-1471
28. Larocca LM, Capello D, Rinelli A, Nori S, Antinori A, Gloghini A, Cingolani A, Migliazza A, Saglio G, Cammilleri-Broet S, Raphael M, Carbone A, Gaidano G (1998) The molecular and phenotypic profile of primary central nervous system lymphoma identifies distinct categories of the disease and is consistent with histogenetic derivation from germinal center-related B cells. Blood 92: 1011-1019
29. Levine EG, Arthur DC, Machnicki J, Frizzera G, Hurd D, Peterson B, Gajl-Peczalska KJ, Bloomfield C (1989) Four new recurring translocations in non-Hodgkin lymphoma. Blood 74: 1796-1800
30. Lichter P, Bentz M, Joos S (1995) Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization. Methods Enzym 254: 334-359
31. Liu J, Johnson RM, Traweek ST (1993) Rearrangement of the BCL-2 gene in follicular lymphoma. Detection by PCR in both fresh and fixed tissue samples. Diagn Mol Pathol 2: 241-247
32. Merup M, Moreno TC, Heyman M, Ronnberg K, Grander D, Detlofsson R, Rasool O, Liu Y, Soderhall S, Juliusson G, Gahrton G, Einhorn S (1998) 6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas. Blood 91: 3397-3400
33. Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis DN, Cohen H (1994) Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The Massachusetts General Hospital experience 1958-1989. Cancer 74: 1383-1397
34. Monni O, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S (1997) BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 90: 1168-1174
35. Monni O, Joensuu H, Franssila K, Knuutila S (1996) DNA copy number changes in diffuse large B-cell lymphoma - comparative genomic hybridization study. Blood 87: 5269-5278
36. Morgello S (1995) Pathogenesis and classification of primary central nervous system lymphoma: an update. Brain Pathol 5: 383-393
37. Morgello S, Tagliati M, Ewart MR (1997) HHV-8 and AIDS-related CNS lymphoma. Neurology 48: 1333-1335
38. Offit K, Parsa NZ, Gaidano G, Filippa DA, Louie D, Pan D, Jhanwar SC, Dalla-Favera R, Chaganti RSK (1993) 6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma. Blood 82: 2157-2162
39. Ott G, Katzenberger T, Greiner A, Kalla J, Rosenwald A, Heinrich U, Ott MM, Müller-Hermelink HK (1997) The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT-) type. Cancer Res 57: 3944-3948
40. Paietta E, Van-Ness B, Le Beau MM, Bennett J, Cassileth P, Wiernik PH (1992) Translocation (2;9)(p12;p23) in a case of acute leukemia with t(4;11)(q21;q23). Lack of rearrangement of the kappa and interferon gene loci. Cancer Genet Cytogenet 60: 82-85
41. Pinkel D, Straume T, Gray JW (1986) Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83: 2934-2938
42. Piper J, Rutovitz D, Sudar D, Kallioniemi A, Kallioniemi O-P, Waldman FM, Gray JW, Pinkel D (1995) Computer image analysis of comparative genomic hybridization. Cytometry 19: 10-26
43. Rao PH, Houldsworth J, Dyomina K, Parsa NZ, Cigudosa JC, Louie DC, Popplewell L, Offit K, Jhanwar SC, Chaganti RS (1998) Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood 92: 234-240
44. Reifenberger J, Ring GU, Gies U, Cobbers JMJL, Oberstraß J, An H-X, Niederacher D, Wechsler W, Reifenberger G (1996) Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. J Neuropathol Exp Neurol 55:822-831
45. Rimokh R, Gadoux M, Bertheas M-F, Berger F, Garoscio M, Deleage G, Germain D, Magaud J-P (1993) FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Blood 81: 136-142
46. Schouten HC, Sanger WG, Weisenburger DD, Armitage JO (1990) Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma. Nebraska Lymphoma Study Group. Cancer Genet Cytogenet 47: 73-82
47. Schütz BR, Scheurlen W, Krauss J, du Manoir S, Joos S, Bentz M, Lichter P (1996) Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization. Genes Chromosom Cancer 16: 196-203
48. Solinas-Toldo S, Lampel S, Stilgenbauer S, Nickolenko J, Benner A, Döhner H, Cremer T, Lichter P (1997) Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances. Genes Chromosom Cancer 20: 399-407
49. Speicher MR, Jauch A, Walt H, du Manoir S, Ried T, Jochum W, Sulser T, Cremer T (1995) Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics. Am J Pathol 146: 1332-1340
50. Tanaka S, Louie DC, Kant JA, Reed JC (1992) Frequent incidence of somatic hypermutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Blood 79: 229-237
51. Telenius H, Carter NP, Bebb CE, Nordenskjöld M, Ponder BAJ, Tunnacliffe A (1992) Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer. Genomics 13: 718-725
52. Volpe G, Vitolo U, Carbone A, Pastore C, Bertini M, Botto B, Audisio E, Freilone R, Novero D, Cappia S, De Giuli P, Mazza U, Resegotti L, Palestro G, Saglio G, Gaidano G (1996) Molecular Heterogeneity of B-lineage diffuse large cell lymphoma. Genes Chromosom Cancer 16: 21-30
53. Weber RG, Boström J, Wolter M, Baudis M, Collins VP, Reifenberger G, Lichter P (1997) Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningioma progression. Proc Natl Acad Sci USA 94: 14719-14724
54. Weber RG, Scheer M, Born IA, Joos S, Cobbers JM, Hofele C, Reifenberger G, Zöller JE, Lichter P (1998) Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization. Am J Pathol 153: 295-303
55. Werner CA, Döhner H, Barth TF, Stilgenbauer S, Plesch A, Lichter P, Bentz M (1998) Molecular cytogenetic analysis of low-grade B-cell neoplasias: a comparative genomic hybridization study. Recent Results Cancer Res 144: 53-60
56. Werner CA, Döhner H, Joos S, Trümper LH, Baudis M, Barth TFE, Ott G, Möller P, Lichter P, Bentz M (1997) High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. Am J Pathol 151: 335-342
57. Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (1999) Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96: 35-45
58. Wiltshire RN, Duray P, Bittner ML, Visakorpi T, Meltzer PS, Tuthill RJ, Liotta LA, Trent JM (1995) Direct visualization of the clonal progression of primary cutaneous melanoma: Application of tissue microdissection and comparative genomic hybridization. Cancer Res 55: 3954-3957
59. Younes A, Pugh W, Goodacre A, Katz R, Rodriguez MA, Hill D, Cabanillas F, Andreeff M (1994) Polysomy of chromosome 12 in 60 patients with non-Hodgkin's lymphoma assessed by fluorescence in situ hybridization: differences between follicular and diffuse large cell lymphoma. Genes Chromosom Cancer 9: 161-167
60. Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW (1999) Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet 22: 63-68
61. Zhang SJ, Endo S, Ichikawa T, Washiyama K, Kumanishi T (1998) Frequent deletion and 5′ CpG island methylation of the p16 gene in primary malignant lymphoma of the brain. Cancer Res 58: 1231-1237