Gene expression profile of vascular endothelial growth factor (VEGF) and its receptors in various cell types of the canine lymph node using laser capture microdissection (LCM)

Veterinary Immunology and Immunopathology

Volumn 140, Issue 3-4, 2011, Pages 207-214

  Jais, Alexander ^a   Klein, Dieter ^a   Wolfesberger, Birgitt ^a   Walter, Ingrid ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Canine; Gene expression; Laser dissection microscopy; Lymph node; VEGF

Indexed keywords

BETA 2 MICROGLOBULIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; RIBOSOME RNA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ACCURACY; ANALYZER; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL ISOLATION; CELL TYPE; DOG; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; LASER CAPTURE MICRODISSECTION; LYMPH NODE; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MICROENVIRONMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DOGS; GENE EXPRESSION PROFILING; LASERS; LYMPH NODES; MICRODISSECTION; POLYMERASE CHAIN REACTION; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 79952193035     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2010.12.005     Document Type: Article

References (44)

1. Al-Dissi A.N., Haines D.M., et al. Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor associated with tumour cell proliferation in canine cutaneous squamous cell carcinomas and trichoepitheliomas. Vet. Pathol. 2007, 44(6):823-830.
2. Andersen C.L., Jensen J.L., et al. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004, 64(15):5245-5250.
3. Barleon B., Sozzani S., et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996, 87(8):3336-3343.
4. Berse B., Brown L.F., et al. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumours. Mol. Biol. Cell 1992, 3(2):211-220.
5. Blakey G.L., Laszik Z.G. Laser-assisted microdissection of the kidney: fundamentals and applications. J. Mol. Histol. 2004, 35(6):581-587.
6. Byrne A.M., Bouchier-Hayes D.J., et al. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell Mol. Med. 2005, 9(4):777-794.
7. Chung E.S., Chauhan S.K., et al. Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. Am. J. Pathol. 2009, 175(5):1984-1992.
8. Connolly D.T., Olander J.V., et al. Human vascular permeability factor. Isolation from U937 cells. J. Biol. Chem. 1989, 264(33):20017-20024.
9. Ferrara N. Vascular endothelial growth factor. Eur. J. Cancer 1996, 32A(14):2413-2422.
10. Ferrara N., Gerber H.P., et al. The biology of VEGF and its receptors. Nat. Med. 2003, 9(6):669-676.
11. Gabrilovich D., Ishida T., et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoetic lineages in vivo. Blood 1998, 1(29):4150-4166.
12. Haroon Z.A., Raleigh J.A., et al. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann. Surg. 2000, 231(1):137-147.
13. Hiratsuka S., Minowa O., et al. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. U.S.A. 1998, 95(16):9349-9354.
14. Houck K.A., Leung D.W., et al. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 1992, 267(36):26031-26037.
15. Huang Y., Chen X., et al. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 2007, 110(2):624-631.
16. Jingjing L., Srinivasan B., et al. Vascular endothelial growth factor is increased following coronary artery occlusion in the dog heart. Mol. Cell Biochem. 2000, 214(1-2):23-30.
17. Kerman I.A., Buck B.J., et al. Combining laser capture microdissection with quantitative real-time PCR: effects of tissue manipulation on RNA quality and gene expression. J. Neurosci. Methods 2006, 153(1):71-85.
18. Kim K.J., Li B., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 362(6423):841-844.
19. Klein D. Quantification using real-time PCR technology: applications and limitations. Trends Mol. Med. 2002, 8(6):257-260.
20. Klein D., Janda P., et al. Proviral load determination of different feline immunodeficiency virus isolates using real-time polymerase chain reaction: influence of mismatches on quantification. Electrophoresis 1999, 20(2):291-299.
21. Kolm G., Klein D., et al. Lactoferrin expression in the horse endometrium: relevance in persisting mating-induced endometritis. Vet. Immunol. Immunopathol. 2006, 114(1-2):159-167.
22. Kvanta A., Sarman S., et al. Expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in inflammation-associated corneal neovascularization. Exp. Eye Res. 2000, 70(4):419-428.
23. Leek R.D., Hunt N.C., et al. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 2000, 190(4):430-436.
24. Li R., Wheeler T.M., et al. Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in human prostate. Prostate 2004, 1(58):193-199.
25. Matiasek L.A., Platt S.R., et al. Ki-67 and vascular endothelial growth factor expression in intracranial meningiomas in dogs. J. Vet. Intern. Med. 2009, 23(1):146-151.
26. Maruyama K., Li M., et al. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J. Clin. Invest. 2005, 115(9):2363-2372.
27. Mor F., Quintana F.J., et al. Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J. Immunol. 2004, 172(7):4618-4623.
28. Muller Y.A., Li B., et al. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc. Natl. Acad. Sci. U.S.A. 1997, 94(14):7192-7197.
29. Peters I.R., Peeters D., et al. Development and application of multiple internal reference (housekeeper) gene assays for accurate normalization of canine gene expression studies. Vet. Immunol. Immunopathol. 2007, 117(1-2):55-66.
30. Pfaffl M.W., Horgan G.W., et al. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002, 30(9):e36.
31. Ramakers C., Ruijter J.M., et al. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci. Lett, 2003, 339(1):62-66.
32. Restucci B., Maiolino P., et al. Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry. J. Comp. Pathol. 2003, 128(4):252-259.
33. Restucci B., Papparella S., et al. Expression of vascular endothelial growth factor in canine mammary tumours. Vet. Pathol. 2002, 39(4):488-493.
34. Sawano A., Iwai S., Sakurai Y., Ito M., Shitara K., Nakahata T., Shibuya M. Flt-1, vascular endothelial growth factor receptor 1 is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001, 97(3):785-791.
35. Skobe M., Hamberg L.M., et al. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am. J. Pathol. 2001, 159(3):893-903.
36. Scheidegger P., Weiglhofer W., et al. Vascular endothelial growth factor (VEGF) and its receptors in tumour-bearing dogs. Biol. Chem. 1999, 380(12):1449-1454.
37. Schoppmann S.F., Birner P., et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am. J. Pathol. 2002, 161(3):947-956.
38. Senger D.R., Galli S.J., et al. Tumour cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219(4587):983-985.
39. Swift M.E., Kleinman H.K., et al. Impaired wound repair and delayed angiogenesis in aged mice. Lab. Invest. 1999, 79(12):1479-1487.
40. Uchida N., Nagai K., et al. Distribution of VEGF and flt-1 in the normal dog tissues. J. Vet. Med. Sci. 2008, 70(11):1273-1276.
41. Vandesompele J., De Preter K., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3(7). RESEARCH0034.
42. Waltenberger J., Claesson-Welsh L., et al. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 1994, 269(43):26988-26995.
43. Wolfesberger B., Guija de Arespacohaga A., et al. Expression of vascular endothelial growth factor and its receptors in canine lymphoma. J. Comp. Pathol. 2007, 137(1):30-40.
44. Yang Z.F., Poon R.T., et al. Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. J. Immunol. 2004, 173(4):2507-2515.