Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase

Journal of Medicinal Chemistry

Volumn 49, Issue 16, 2006, Pages 5018-5022

  Rejman, Dominik ^a,d   Olesiak, Magda ^a   Chen, Liqiang ^a   Patterson, Steven E ^a   Wilson, Daniel ^a   Jayaram, Hiramagalur N ^b   Hedstrom, Lizbeth ^c   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRANDEIS UNIVERSITY   (United States)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINATE DEHYDROGENASE; MIZORIBINE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N6 DIBENZOYL 2',3' O DIBENZOYL 5' YL (O BENZYL)HYDROXYMETHYLPHOSPHONATE; P1 [7 HYDROXY 6 (ETHYL 2 YL) 5 METHOXY 4 METHYLPHTHALAN 1 ONE]METHYLENEPHOSPHO P2 (ADENOSIN 5' YL)PHOSPHONATE; RIBAVIRIN; TIAZOFURIN; UNCLASSIFIED DRUG;

ARTICLE; DEPROTECTION REACTION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; OXIDATION;

ADENINE NUCLEOTIDES; ADENOSINE MONOPHOSPHATE; HUMANS; IMP DEHYDROGENASE; MYCOPHENOLIC ACID; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746911968     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060479r     Document Type: Article

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