Immune pathomechanism of drug hypersensitivity reactions

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 3 SUPPL., 2011, Pages

  Pichler, Werner J ^a   Naisbitt, Dean J ^b   Park, B Kevin ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

dendritic cells; Drug hypersensitivity; hapten; p i concept; prohapten; T lymphocytes

Indexed keywords

ABACAVIR; ALLOPURINOL; AMOXICILLIN; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; BETA LACTAM ANTIBIOTIC; CARBAMAZEPINE; CARRIER PROTEIN; CYTOKINE; FLUCLOXACILLIN; GRANULYSIN; HAPTEN; HLA B ANTIGEN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SULFAMETHOXAZOLE; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHINESE; CONFERENCE PAPER; CYSTIC FIBROSIS; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG BINDING SITE; DRUG HYPERSENSITIVITY; DRUG METABOLISM; HLA SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERSENSITIVITY REACTION; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INFECTIOUS MONONUCLEOSIS; INNATE IMMUNITY; LIVER TOXICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; PHARMACOGENETICS; PRIORITY JOURNAL; RECURRENT INFECTION; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFECTION; RISK FACTOR; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS;

DENDRITIC CELLS; DRUG HYPERSENSITIVITY; FEMALE; HAPTENS; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; MALE; RECEPTORS, ANTIGEN, T-CELL; SEX FACTORS; SKIN DISEASES; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 79952179441     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.11.048     Document Type: Conference Paper

References (57)

1. A. Alfirevic, and M. Pirmohamed Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future Pharmacogenomics 11 2010 497 499
2. W.J. Pichler Delayed drug hypersensitivity reactions Ann Intern Med 139 2003 683 693
3. D.J. Naisbitt, S.F. Gordon, M. Pirmohamed, and B.K. Park Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment Drug Saf 23 2000 483 507 (Pubitemid 32001512)
4. K. Landsteiner, and J. Jacobs Studies on the sensitization of animals with simple chemical compounds J Exp Med 61 1935 643 656
5. B.B. Levine, and Z. Ovary Studies on the mechanism of the formation of the penicillin antigen J Exp Med 114 1961 875 904
6. B.B. Levine, and A.P. Redmond Minor haptenic determinant-specific reagins of penicillin hypersensitivity in man Int Arch Allergy Appl Immunol 35 1969 445 455
7. F.R. Batchelor, J.M. Dewdney, and D. Gazzard Penicillin allergy: the formation of the penicilloyl determinant Nature 206 1965 362 364
8. R.E. Jenkins, X. Meng, V.L. Elliott, N.R. Kitteringham, M. Pirmohamed, and B.K. Park Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo Proteomics Clin Applications 3 2009 720 729
9. H.U. Weltzien, and E. Padovan Molecular features of penicillin allergy J Invest Dermatol 110 1998 203 206 (Pubitemid 28144591)
10. C. Brander, D. Mauri-Hellweg, F. Bettens, H. Rolli, M. Goldman, and W.J. Pichler Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals J Immunol 155 1995 2670 2678
11. R. Megherbi, E. Kiorpelidou, B. Foster, C. Rowe, D.J. Naisbitt, and C.E. Goldring Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 Toxicol Appl Pharmacol 238 2009 120 132
12. M. Mizuashi, T. Ohtani, S. Nakagawa, and S. Aiba Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells J Invest Dermatol 124 2005 579 586 (Pubitemid 40381581)
13. S. Gallucci, M. Lolkema, and P. Matzinger Natural adjuvants: endogenous activators of dendritic cells Nat Med 5 1999 1249 1255 (Pubitemid 29535601)
14. P. Matzinger Tolerance, danger, and the extended family Annu Rev Immunol 12 1994 991 1045 (Pubitemid 24140436)
15. Y. Kano, and T. Shiohara The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug Immunol Allergy Clin North Am 29 2009 481 501
16. S.F. Martin, and T. Jakob From innate to adaptive immune responses in contact hypersensitivity Curr Opin Allergy Clin Immunol 8 2008 289 293
17. R. Rodriguez-Pena, S. Lopez, C. Mayorga, C. Antunez, T.D. Fernandez, and M.J. Torres Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams J Allergy Clin Immunol 118 2006 949 956 (Pubitemid 44498760)
18. J.P. Sanderson, D.J. Naisbitt, J. Farrell, C.A. Ashby, M.J. Tucker, and M.J. Rieder Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling J Immunol 178 2007 5533 5542 (Pubitemid 46674348)
19. A.M. Martin, C.A. Almeida, P. Cameron, A.W. Purcell, D. Nolan, and I. James Immune responses to abacavir in antigen-presenting cells from hypersensitive patients AIDS 21 2007 1233 1244 (Pubitemid 46883477)
20. W. Tang, and A.Y. Lu Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective Drug Metab Rev 42 2010 225 249
21. G.A. Doss, and T.A. Baillie Addressing metabolic activation as an integral component of drug design Drug Metab Rev 38 2006 641 649 (Pubitemid 44903260)
22. A.E. Cribb, and S.P. Spielberg Sulfamethoxazole is metabolized to the hydroxylamine in humans Clin Pharmacol Ther 51 1992 522 526
23. D.J. Naisbitt, P.M. O'Neill, M. Pirmohamed, and B.K. Park Synthesis and reactions of nitroso sulfamethoxazole with biological nucleophiles - implications for immune-mediated toxicity Bioorg Med Chem Let 6 1996 1511 1516 (Pubitemid 27377754)
24. A.E. Cribb, M. Miller, J.S. Leeder, J. Hill, and S.P. Spielberg Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity Drug Metab Dispos 19 1991 900 906
25. T. Manchanda, D. Hess, L. Dale, S.G. Ferguson, and M.J. Rieder Haptenation of sulfonamide reactive metabolites to cellular proteins Mol Pharmacol 62 2002 1011 1026 (Pubitemid 35222492)
26. D.J. Naisbitt, S.J. Hough, H.J. Gill, M. Pirmohamed, N.R. Kitteringham, and B.K. Park Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity Br J Pharmacol 126 1999 1393 1407 (Pubitemid 29142071)
27. H.E. Callan, R.E. Jenkins, J.L. Maggs, S.N. Lavergne, S.E. Clarke, and D.J. Naisbitt Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation Chem Res Toxicol 22 2009 937 948
28. B. Schnyder, C. Burkhart, K. Schnyder-Frutig, S. von Greyerz, D.J. Naisbitt, and M. Pirmohamed Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals J Immunol 164 2000 6647 6654 (Pubitemid 30408852)
29. C. Burkhart, S. von Greyerz, J.P. Depta, D.J. Naisbitt, M. Britschgi, and K.B. Park Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells Br J Pharmacol 132 2001 623 630 (Pubitemid 32165177)
30. A. Nassif, A. Bensussan, L. Boumsell, A. Deniaud, H. Moslehi, and P. Wolkenstein Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells J Allergy Clin Immunol 114 2004 1209 1215 (Pubitemid 39469167)
31. J.L. Castrejon, N. Berry, S. El-Ghaiesh, B.O. Gerber, W.J. Pichler, and B.K. Park Stimulation of T-cells with sulfonamides and sulfonamide metabolites J Allergy Clin Immunol 125 2010 411 418
32. S.N. Lavergne, H. Wang, H.E. Callan, B.K. Park, and D.J. Naisbitt "Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells J Pharmacol Exp Ther 331 2009 372 381
33. J.M. Baron, T. Wiederholt, R. Heise, H.F. Merk, and D.R. Bickers Expression and function of cytochrome p450-dependent enzymes in human skin cells Curr Med Chem 15 2008 2258 2264
34. M.A. Bergstrom, H. Ott, A. Carlsson, M. Neis, G. Zwadlo-Klarwasser, and C.A. Jonsson A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites J Invest Dermatol 127 2007 1145 1153 (Pubitemid 46625132)
35. M.M. Neis, A. Wendel, T. Wiederholt, Y. Marquardt, S. Joussen, and J.M. Baron Expression and induction of cytochrome p450 isoenzymes in human skin equivalents Skin Pharmacol Physiol 23 2010 29 39
36. G. Wermuth, C.R. Ganellin, P. Lindberg, and L.A. Mitscher Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998) Pure Appl Chem 70 1998 1129 1143
37. W.J. Pichler Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept Curr Opin Allergy Clin Immunol 2 2002 301 305 (Pubitemid 36869638)
38. W.J. Pichler Direct T-cell stimulations by drugs - bypassing the innate immune system Toxicology 209 2005 95 100 (Pubitemid 40568634)
39. W.J. Pichler, A. Beeler, M. Keller, M. Lerch, S. Posadas, and D. Schmid Pharmacological interaction of drugs with immune receptors: the p-i concept Allergol Int 55 2006 17 25
40. C.W. Yang, S.I. Hung, C.G. Juo, Y.P. Lin, W.H. Fang, and I.H. Lu HLA-B1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome J Allergy Clin Immunol 120 2007 870 877
41. S. Mallal, D. Nolan, C. Witt, G. Masel, A.M. Martin, and C. Moore Association between presence of HLA-B5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir Lancet 359 2002 727 732 (Pubitemid 34215071)
42. W.H. Chung, S.I. Hung, H.S. Hong, M.S. Hsih, L.C. Yang, and H.C. Ho Medical genetics: a marker for Stevens-Johnson syndrome Nature 428 2004 486
43. A.K. Daly, P.T. Donaldson, P. Bhatnagar, Y. Shen, I. Pe'er, and A. Floratos HLA-B5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin Nat Genet 41 2009 816 819
44. C.B. Man, P. Kwan, L. Baum, E. Yu, K.M. Lau, and A.S. Cheng Association between HLA-B1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese Epilepsia 48 2007 1015 1018 (Pubitemid 46763406)
45. W. Tassaneeyakul, T. Jantararoungtong, P. Chen, P.Y. Lin, S. Tiamkao, and U. Khunarkornsiri Strong association between HLA-B5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population Pharmacogenet Genomics 19 2009 704 709
46. A. Kindmark, A. Jawaid, C.G. Harbron, B.J. Barratt, O.F. Bengtsson, and T.B. Andersson Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis Pharmacogenomics J 8 2008 186 195 (Pubitemid 351712643)
47. D. Chessman, L. Kostenko, T. Lethborg, A.W. Purcell, N.A. Williamson, and Z. Chen Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity Immunity 28 2008 822 832 (Pubitemid 351784513)
48. C. Burkhart, M. Britschgi, I. Strasser, J.P. Depta, S. von Greyerz, and V. Barnaba Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides Clin Exp Allergy 32 2002 1635 1643 (Pubitemid 35370541)
49. S. von Greyerz, G. Bultemann, K. Schnyder, C. Burkhart, B. Lotti, and Y. Hari Degeneracy and additional alloreactivity of drug-specific human alpha beta(+) T cell clones Int Immunol 13 2001 877 885 (Pubitemid 32691109)
50. W.J. Pichler, J. Adam, B. Daubner, T. Gentinetta, M. Keller, and D. Yerly Drug hypersensitivity reactions: pathomechanism and clinical symptoms Med Clin North Am 94 2010 645 664 xv
51. A. Rozieres, M. Vocanson, K. Rodet, J. Benetiere, J. Bienvenu, and F. Berard CD8+ T cells mediate skin allergy to amoxicillin in a mouse model Allergy 65 2010 996 1003
52. W.H. Chung, S.I. Hung, J.Y. Yang, S.C. Su, S.P. Huang, and C.Y. Wei Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis Nat Med 14 2008 1343 1350
53. R. Abe, N. Yoshioka, J. Murata, Y. Fujita, and H. Shimizu Granulysin as a marker for early diagnosis of the Stevens-Johnson syndrome Ann Intern Med 151 2009 514 515
54. C. Koch, K. Hjelt, S.S. Pedersen, E.T. Jensen, T. Jensen, and S. Lanng Retrospective clinical study of hypersensitivity reactions to aztreonam and six other beta-lactam antibiotics in cystic fibrosis patients receiving multiple treatment courses Rev Infect Dis 13 suppl 7 1991 S608 S611
55. R.A. Pleasants, T.R. Walker, and W.M. Samuelson Allergic reactions to parenteral beta-lactam antibiotics in patients with cystic fibrosis Chest 106 1994 1124 1128 (Pubitemid 24309550)
56. A. Beeler, O. Engler, B.O. Gerber, and W.J. Pichler Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions J Allergy Clin Immunol 117 2006 455 462 (Pubitemid 43190160)
57. R. Takahashi, Y. Kano, Y. Yamazaki, M. Kimishima, Y. Mizukawa, and T. Shiohara Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome J Immunol 182 2009 8071 8079