The discodermia calyx toxin calyculin A enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells

Toxins

Volumn 3, Issue 1, 2011, Pages 105-119

  Edelson, Jessica R ^a   Brautigan, David L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Calyculin A; Cantharidin; Cyclin D1; Okadaic acid; Phosphatases; Toxins

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALYCULIN A; CANTHARIDIN; CYCLIN D1; CYCLIN D3; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MYOSIN LIGHT CHAIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROGESTERONE RECEPTOR; PROTEIN SERINE THREONINE KINASE; S6 KINASE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SPONGE (PORIFERA);

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL CYCLE CHECKPOINTS; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MARINE TOXINS; MCF-7 CELLS; OXAZOLES; PHOSPHORYLATION; PORIFERA; PROTEIN ARRAY ANALYSIS; PROTEOLYSIS;

DISCODERMIA CALYX;

EID: 79952155653     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3010105     Document Type: Article

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