Diuretic drug binding to human glutathione transferase P1-1: Potential role of Cys-101 revealed in the double mutant C47S/Y108V

Journal of Molecular Recognition

Volumn 24, Issue 2, 2011, Pages 220-234

  Quesada Soriano, Indalecio ^a   Parker, Lorien J ^b,c   Primavera, Alessandra ^d   Wielens, Jerome ^b   Holien, Jessica K ^b   Casas Solvas, Juan M ^a   Vargas Berenguel, Antonio ^a   Aguilera, Ana M ^a   Nuccetelli, Marzia ^d   Mazzetti, Anna P ^d   Bello, Mario Lo ^d   Parker, Michael W ^b,c   García Fuentes, Luis ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

binding; calorimetry; crystallography; docking studies; ethacrynic acid; glutathione transferase; kinetic studies; protein ligand interaction; thermodynamic

Indexed keywords

CYSTEINE; DIURETIC AGENT; ETACRYNIC ACID; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PH; PROTEIN MULTIMERIZATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DIURETICS; ENZYME ACTIVATION; ETHACRYNIC ACID; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 79952151927     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.1040     Document Type: Article

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