Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

Protein Science

Volumn 18, Issue 12, 2009, Pages 2454-2470

  Quesada Soriano, Indalecio ^a   Parker, Lorien J ^b,c   Primavera, Alessandra ^d   Casas Solvas, Juan M ^a   Vargas Berenguel, Antonio ^a   Barón, Carmen ^a   Morton, Craig J ^b   Mazzetti, Anna Paola ^d   Lo Bello, Mario ^d   Parker, Michael W ^b,c   García Fuentes, Luis ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Binding; Calorimetry; EA conjugates; Ethacrynic acid; Glutathione S transferase; Thermal stability; X ray crystallography

Indexed keywords

ETACRYNIC ACID; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENTROPY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DIURETICS; ETHACRYNIC ACID; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN BINDING; PROTEIN STABILITY; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; TITRIMETRY;

EID: 73149093229     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.253     Document Type: Article

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