Modulating Catalytic Activity by Unnatural Amino Acid Residues in a GSH-Binding Loop of GST P1-1

Journal of Molecular Biology

Volumn 376, Issue 3, 2008, Pages 811-826

  Hegazy, Usama M ^a   Tars, Kaspars ^a   Hellman, Ulf ^a   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

activation energy; GSH binding; GST P1 1 mutant structure; human glutathione transferase P1 1; site specific chemical modification

Indexed keywords

ALANINE; AMINO ACID; CYSTINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE P1 1; S HEXYLGLUTATHIONE; TYROSINE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; ENZYME DENATURATION; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; WILD TYPE;

EID: 38649114683     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.12.013     Document Type: Article

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