Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling

Stem Cells

Volumn 29, Issue 2, 2011, Pages 320-331

  Moon, Byoung San ^a   Kim, Hyun Yi ^a   Kim, Mi Yeon ^a   Yang, Dong Hwa ^a   Lee, Jong Min ^b   Cho, Kyoung Won ^b   Jung, Han Sung ^b   Choi, Kang Yell ^a  

^a Yonsei University   (South Korea)

^b Yonsei University College of Dentistry   (South Korea)

Author keywords

Differentiation; ERK signaling; Neural stem cells; Neurogenesis; Proliferation; Scaffold protein; Sur8

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COMPLEMENTARY DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SCAFFOLD PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SUR8 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL RENEWAL; CONFOCAL MICROSCOPY; EMBRYO; EMBRYO CULTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; IN SITU HYBRIDIZATION; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUPEPTINS; MAP KINASE SIGNALING SYSTEM; NEURAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

LENTIVIRUS; RATTUS;

EID: 79952144213     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.586     Document Type: Article

References (53)

1. Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003;19: 91-118. (Pubitemid 37487344)
2. Zeke A, Lukacs M, Lim WA et al. Scaffolds: Interaction platforms for cellular signalling circuits. Trends Cell Biol 2009;19:364-374.
3. Rushworth LK, Hindley AD, O'Neill E et al. Regulation and role of Raf-1/B-Raf heterodimerization. Mol Cell Biol 2006;26:2262-2272. (Pubitemid 43346926)
4. Selfors LM, Schutzman JL, Borland CZ et al. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Proc Natl Acad Sci USA 1998;95:6903-6908. (Pubitemid 28278079)
5. Chang C, Hopper NA, Sternberg PW. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO J 2000;19:3283-3294. (Pubitemid 30428206)
6. Rodriguez-Viciana P, Oses-Prieto J, Burlingame A et al. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell 2006;22:217-230.
7. Sieburth DS, Sun Q, Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell 1998;94:119-130. (Pubitemid 28347475)
8. Li W, Han M, Guan KL. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev 2000;14:895-900. (Pubitemid 30252998)
9. Migita H, Kominami K, Higashida M et al. Activation of adenosine A1 receptor-induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways. J Neurosci Res 2008;86:2820-2828.
10. Samuels IS, Karlo JC, Faruzzi AN et al. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 2008;28:6983-6995.
11. Jung GA, Yoon JY, Moon BS et al. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway. BMC Cell Biol 2008; 9:66.
12. Suzuki S, Namiki J, Shibata S et al. The neural stem/progenitor cell marker nestin is expressed in proliferative endothelial cells, but not in mature vasculature. J Histochem Cytochem 2010;58:721-730.
13. Okuno K, Ohta S, Kato H et al. Expression of neural stem cell markers in malignant rhabdoid tumor cell lines. Oncol Rep 2010;23: 485-492.
14. Kim JB, Sebastiano V, Wu G et al. Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136:411-419.
15. Osterberg N, Roussa E. Characterization of primary neurospheres generated from mouse ventral rostral hindbrain. Cell Tissue Res 2009; 336:11-20.
16. Bisson I, Prowse DM. WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 2009;19:683-697.
17. Gage FH. Mammalian neural stem cells. Science 2000;287: 1433-1438. (Pubitemid 30127128)
18. Dull T, Zufferey R, Kelly M et al. A third-generation lentivirus vector with a conditional packaging system. J Virol 1998;72:8463-8471. (Pubitemid 28471781)
19. Follenzi A, Ailles LE, Bakovic S et al. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet 2000;25:217-222. (Pubitemid 30394997)
20. Li Q, Lau A, Morris TJ et al. A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: Analysis by quantitative immunocolocalization. J Neurosci 2004;24:4070-4081. (Pubitemid 38544233)
21. Pepin MC, Beaulieu S, Barden N. Differential regulation by dexamethasone of glucocorticoid receptor messenger RNA concentrations in neuronal cultures derived from fetal rat hypothalamus and cerebral cortex. Cell Mol Neurobiol 1990;10:227-235. (Pubitemid 20295713)
22. Osumi N, Inoue T. Gene transfer into cultured mammalian embryos by electroporation. Methods 2001;24:35-42. (Pubitemid 32846440)
23. Tabocova S, Hunter ES, III, Gladen BC. Developmental toxicity of inorganic arsenic in whole embryo: Culture oxidation state, dose, time, and gestational age dependence. Toxicol Appl Pharmacol 1996; 138:298-307.
24. Reuss B, von Bohlen und Halbach O. Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res 2003; 313:139-157. (Pubitemid 37129946)
25. Chong YK, Toh TB, Zaiden N et al. Cryopreservation of neurospheres derived from human glioblastoma multiforme. Stem Cells 2009;27: 29-39.
26. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-1710.
27. Reynolds BA, Weiss S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 1996;175:1-13. (Pubitemid 26150042)
28. Weiss S, van der Kooy D. CNS stem cells: Where's the biology (a.k.a. beef)? J Neurobiol 1998;36:307-314. (Pubitemid 28363238)
29. McKay RD. Brain stem cells change their identity. Nat Med 1999;5: 261-262.
30. Nakatani Y, Yanagisawa M, Suzuki Y et al. Characterization of GD3 ganglioside as a novel biomarker of mouse neural stem cells. Glycobiology 2010;20:78-86.
31. Cordeddu V, Di Schiavi E, Pennacchio LA et al. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Nat Genet 2009;41: 1022-1026.
32. Flotho C, Batz C, Hasle H et al. Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML. Blood 2010;115: 913.
33. Yi J, Chen M, Wu X et al. Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn 2010;239:2005-2013.
34. Wang P, Chen LL, Yan H et al. Trichosanthin suppresses HeLa cell proliferation through inhibition of the PKC/MAPK signaling pathway. Cell Biol Toxicol 2009;25:479-488.
35. Zhang L, Li X, Zhao L et al. Nongenomic effect of estrogen on the MAPK signaling pathway and calcium influx in endometrial carcinoma cells. J Cell Biochem 2009;106:553-562.
36. Cowley S, Paterson H, Kemp P et al. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994;77:841-852. (Pubitemid 24187682)
37. Fukuda M, Gotoh Y, Tachibana T et al. Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene 1995;11: 239-244.
38. Qui MS, Green SH. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity. Neuron 1992;9:705-717.
39. Vaudry D, Stork PJ, Lazarovici P et al. Signaling pathways for PC12 cell differentiation: Making the right connections. Science 2002;296: 1648-1649. (Pubitemid 34579153)
40. Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976;73:2424-2428.
41. Yamada M, Ikeuchi T, Hatanaka H. The neurotrophic action and signalling of epidermal growth factor. Prog Neurobiol 1997;51:19-37. (Pubitemid 27080813)
42. Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of ERK MAP kinase activity: Mechanisms for providing signaling specificity. J Cell Sci 2005;118:2997-3002. (Pubitemid 41149904)
43. Marshall CJ. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179-185.
44. Klesse LJ, Meyers KA, Marshall CJ et al. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene 1999;18:2055-2068.
45. Santos SD, Verveer PJ, Bastiaens PI. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 2007;9:324-330. (Pubitemid 46344612)
46. Anselmo AN, Bumeister R, Thomas JM et al. Critical contribution of linker proteins to Raf kinase activation. J Biol Chem 2002;277:5940-5943. (Pubitemid 34968374)
47. Schillace RV, Scott JD. Organization of kinases, phosphatases, and receptor signaling complexes. J Clin Invest 1999;103:761-765. (Pubitemid 29152620)
48. Ferrell JE, Jr. What do scaffold proteins really do? Sci STKE 2000; 2000:pe1.
49. Dai P, Xiong WC, Mei L. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem 2006;281:927-933.
50. Levchenko A, Bruck J, Sternberg PW. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci USA 2000;97: 5818-5823. (Pubitemid 30367482)
51. Sun L, Trausch-Azar JS, Ciechanover A et al. Ubiquitin-proteasome- mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. J Biol Chem 2005; 280:26448-26456. (Pubitemid 41022241)
52. Kim SY, Herbst A, Tworkowski KA et al. Skp2 regulates Myc protein stability and activity. Mol Cell 2003;11:1177-1188. (Pubitemid 36645138)
53. Dasgupta B, Gutmann DH. Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo. J Neurosci 2005;25:5584-5594. (Pubitemid 40800650)