Detailed mechanism of squalene epoxidase inhibition by terbinafine

Journal of Chemical Information and Modeling

Volumn 51, Issue 2, 2011, Pages 455-462

  Nowosielski, Marcin ^a   Hoffmann, Marcin ^b   Wyrwicz, Lucjan S ^a,c   Stepniak, Piotr ^a   Plewczynski, Dariusz M ^d   Lazniewski, Michal ^d,e   Ginalski, Krzysztof ^d   Rychlewski, Leszek ^a  

^a BIOINFOBANK INSTITUTE   (Poland)

^b A Mickiewicz University in Poznan   (Poland)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d UNIVERSITY OF WARSAW   (Poland)

^e MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

3D MODELING; ALIPHATIC COMPOUNDS; ATOMS; CHOLESTEROL; ENZYMES; HYDROGEN BONDS; MOLECULAR DYNAMICS; YEAST;

ATTRACTIVE INTERACTIONS; CONFORMATIONAL CHANGE; FLAVIN ADENINE DINUCLEOTIDE; INTERACTION ENERGIES; MOLECULAR DYNAMICS SIMULATIONS; QUANTUM INTERACTIONS; THREE DIMENSIONAL (3-D) MODELING; YEAST SACCHAROMYCES CEREVISIAE;

DRUG PRODUCTS;

ENZYME INHIBITOR; NAPHTHALENE DERIVATIVE; SQUALENE MONOOXYGENASE; TERBINAFINE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; MOLECULAR DYNAMICS; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; THERMODYNAMICS;

ENZYME INHIBITORS; MOLECULAR DYNAMICS SIMULATION; NAPHTHALENES; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SQUALENE MONOOXYGENASE; THERMODYNAMICS;

EID: 79952141712     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci100403b     Document Type: Article

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