메뉴 건너뛰기




Volumn 55, Issue 3, 2011, Pages 455-466

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells

Author keywords

( ) Epigallocatechin 3 gallate; Breast cancer; Estradiol; Nicotine; Nicotinic acetylcholine receptor

Indexed keywords

ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CATECHIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; ESTROGEN; FLAVONOID; MESSENGER RNA; NACHR ALPHA9; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PHENOL DERIVATIVE; POLYPHENOLS;

EID: 79952124971     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000254     Document Type: Article
Times cited : (77)

References (41)
  • 1
    • 43149104180 scopus 로고    scopus 로고
    • Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
    • Lin, Y., Kikuchi, S., Tamakoshi, K., Wakai, K. et al., Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. J. Epidemiol. 2008, 18, 77-83.
    • (2008) J. Epidemiol. , vol.18 , pp. 77-83
    • Lin, Y.1    Kikuchi, S.2    Tamakoshi, K.3    Wakai, K.4
  • 4
    • 0021266137 scopus 로고
    • Nicotine and carbon monoxide intake from high- and low-yield cigarettes
    • Benowitz, N. L., Jacob, P., 3rd, Nicotine and carbon monoxide intake from high- and low-yield cigarettes. Clin. Pharmacol. Ther. 1984, 36, 265-270.
    • (1984) Clin. Pharmacol. Ther. , vol.36 , pp. 265-270
    • Benowitz, N.L.1    Jacob 3rd, P.2
  • 5
    • 0027216120 scopus 로고
    • Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids
    • Lindell, G., Farnebo, L. O., Chen, D., Nexo, E. et al., Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids. Scand. J. Gastroenterol. 1993, 28, 487-494.
    • (1993) Scand. J. Gastroenterol. , vol.28 , pp. 487-494
    • Lindell, G.1    Farnebo, L.O.2    Chen, D.3    Nexo, E.4
  • 6
    • 0037689101 scopus 로고    scopus 로고
    • Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK
    • Mei, J., Hu, H., McEntee, M., Plummer, H., 3rd et al., Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast Cancer Res. Treat. 2003, 79, 95-105.
    • (2003) Breast Cancer Res. Treat. , vol.79 , pp. 95-105
    • Mei, J.1    Hu, H.2    Mcentee, M.3    Plummer 3rd, H.4
  • 7
    • 43749093726 scopus 로고    scopus 로고
    • Precancerous model of human breast epithelial cells induced by NNK for prevention
    • Siriwardhana, N., Choudhary, S., Wang, H. C., Precancerous model of human breast epithelial cells induced by NNK for prevention. Breast Cancer Res. Treat. 2008, 109, 427-441.
    • (2008) Breast Cancer Res. Treat. , vol.109 , pp. 427-441
    • Siriwardhana, N.1    Choudhary, S.2    Wang, H.C.3
  • 8
    • 0034922748 scopus 로고    scopus 로고
    • Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
    • Heeschen, C., Jang, J. J., Weis, M., Pathak, A. et al., Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat. Med. 2001, 7, 833-839.
    • (2001) Nat. Med. , vol.7 , pp. 833-839
    • Heeschen, C.1    Jang, J.J.2    Weis, M.3    Pathak, A.4
  • 9
    • 0033302327 scopus 로고    scopus 로고
    • Pharmacology of neuronal nicotinic acetylcholine recceptors: effects of acute and chronic nicotine
    • discussion S139-S140.
    • Kellar, K. J., Davila-Garcia, M. I., Xiao, Y., Pharmacology of neuronal nicotinic acetylcholine recceptors: effects of acute and chronic nicotine. Nicotine Tob. Res. 1999, 1, S117-S120; discussion S139-S140.
    • (1999) Nicotine Tob. Res. , vol.1
    • Kellar, K.J.1    Davila-Garcia, M.I.2    Xiao, Y.3
  • 10
    • 0032499397 scopus 로고    scopus 로고
    • Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells
    • Schuller, H. M., Orloff, M., Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochem. Pharmacol. 1998, 55, 1377-1384.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1377-1384
    • Schuller, H.M.1    Orloff, M.2
  • 11
    • 21044454180 scopus 로고    scopus 로고
    • Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation
    • Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell, R. G. et al., Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicol. Appl. Pharmacol. 2005, 205, 133-148.
    • (2005) Toxicol. Appl. Pharmacol. , vol.205 , pp. 133-148
    • Ho, Y.S.1    Chen, C.H.2    Wang, Y.J.3    Pestell, R.G.4
  • 12
    • 67649207405 scopus 로고    scopus 로고
    • Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor
    • Wei, P. L., Chang, Y. J., Ho, Y. S., Lee, C. H. et al., Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor. Ann. Surg. 2009, 249, 978-985.
    • (2009) Ann. Surg. , vol.249 , pp. 978-985
    • Wei, P.L.1    Chang, Y.J.2    Ho, Y.S.3    Lee, C.H.4
  • 13
    • 47849132516 scopus 로고    scopus 로고
    • Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells
    • Chen, R. J., Ho, Y. S., Guo, H. R., Wang, Y. J., Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Toxicol. Sci. 2008, 104, 283-293.
    • (2008) Toxicol. Sci. , vol.104 , pp. 283-293
    • Chen, R.J.1    Ho, Y.S.2    Guo, H.R.3    Wang, Y.J.4
  • 14
    • 78651107917 scopus 로고    scopus 로고
    • Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins
    • in press, DOI: 10.1007/s10549-010-0821-3.
    • Chen, C. S., Lee, C. H., Hsieh, C. D., Ho, C. T. et al., Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast Cancer Res. Treat. 2010, in press, DOI: 10.1007/s10549-010-0821-3.
    • (2010) Breast Cancer Res. Treat.
    • Chen, C.S.1    Lee, C.H.2    Hsieh, C.D.3    Ho, C.T.4
  • 15
    • 75249101732 scopus 로고    scopus 로고
    • Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors
    • Shih, Y. L., Liu, H. C., Chen, C. S., Hsu, C. H. et al., Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors. J. Agric. Food Chem. 2010, 58, 235-241.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 235-241
    • Shih, Y.L.1    Liu, H.C.2    Chen, C.S.3    Hsu, C.H.4
  • 16
    • 0242500949 scopus 로고    scopus 로고
    • Factors affecting the levels of tea polyphenols and caffeine in tea leaves
    • Lin, Y. S., Tsai, Y. J., Tsay, J. S., Lin, J. K., Factors affecting the levels of tea polyphenols and caffeine in tea leaves. J. Agric. Food Chem. 2003, 51, 1864-1873.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 1864-1873
    • Lin, Y.S.1    Tsai, Y.J.2    Tsay, J.S.3    Lin, J.K.4
  • 17
    • 0033925366 scopus 로고    scopus 로고
    • Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate
    • Lin, J. K., Chen, P. C., Ho, C. T., Lin-Shiau, S. Y., Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3, 3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate. J. Agric. Food Chem. 2000, 48, 2736-2743.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 2736-2743
    • Lin, J.K.1    Chen, P.C.2    Ho, C.T.3    Lin-Shiau, S.Y.4
  • 18
    • 34447295657 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
    • Pan, M. H., Lin, C. C., Lin, J. K., Chen, W. J., Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. J. Agric. Food Chem. 2007, 55, 5030-5037.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 5030-5037
    • Pan, M.H.1    Lin, C.C.2    Lin, J.K.3    Chen, W.J.4
  • 19
    • 41749117897 scopus 로고    scopus 로고
    • The combination of raloxifene and epigallocatechin gallate suppresses growth and induces apoptosis in MDA-MB-231 cells
    • Stuart, E. C., Rosengren, R. J., The combination of raloxifene and epigallocatechin gallate suppresses growth and induces apoptosis in MDA-MB-231 cells. Life Sci. 2008, 82, 943-948.
    • (2008) Life Sci. , vol.82 , pp. 943-948
    • Stuart, E.C.1    Rosengren, R.J.2
  • 20
    • 66149149841 scopus 로고    scopus 로고
    • Green tea: nature's defense against malignancies
    • Butt, M. S., Sultan, M. T., Green tea: nature's defense against malignancies. Crit. Rev. Food Sci. Nutr. 2009, 49, 463-473.
    • (2009) Crit. Rev. Food Sci. Nutr. , vol.49 , pp. 463-473
    • Butt, M.S.1    Sultan, M.T.2
  • 21
    • 0038353471 scopus 로고    scopus 로고
    • Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells
    • Pan, M. H., Huang, M. C., Wang, Y. J., Lin, J. K., Lin, C. H., Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. J. Agric. Food Chem. 2003, 51, 3977-3984.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3977-3984
    • Pan, M.H.1    Huang, M.C.2    Wang, Y.J.3    Lin, J.K.4    Lin, C.H.5
  • 22
    • 70349210557 scopus 로고    scopus 로고
    • Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1
    • Chen, L. C., Liu, Y. C., Liang, Y. C., Ho, Y. S., Lee, W. S., Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. J. Agric. Food Chem. 2009, 57, 7331-7337.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 7331-7337
    • Chen, L.C.1    Liu, Y.C.2    Liang, Y.C.3    Ho, Y.S.4    Lee, W.S.5
  • 23
    • 0018872895 scopus 로고
    • Estrogen receptors, breast cancer, and smoking
    • Daniell, H. W., Estrogen receptors, breast cancer, and smoking. N. Engl. J. Med. 1980, 302, 1478.
    • (1980) N. Engl. J. Med. , vol.302 , pp. 1478
    • Daniell, H.W.1
  • 24
    • 33947574564 scopus 로고    scopus 로고
    • Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
    • Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K. et al., Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann. NY Acad. Sci. 2006, 1091, 151-169.
    • (2006) Ann. NY Acad. Sci. , vol.1091 , pp. 151-169
    • Aggarwal, B.B.1    Sethi, G.2    Ahn, K.S.3    Sandur, S.K.4
  • 25
    • 42049108836 scopus 로고    scopus 로고
    • Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium
    • Liu, Z., Yu, X., Shaikh, Z. A., Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol. Appl. Pharmacol. 2008, 228, 286-294.
    • (2008) Toxicol. Appl. Pharmacol. , vol.228 , pp. 286-294
    • Liu, Z.1    Yu, X.2    Shaikh, Z.A.3
  • 26
    • 77956608546 scopus 로고    scopus 로고
    • Overexpression and activation of the α9-nicotinic receptor during tumorigenesis in human breast epithelial cells
    • Lee, C. H., Huang, C. S., Chen, C. S., Tu, S. H. et al., Overexpression and activation of the α9-nicotinic receptor during tumorigenesis in human breast epithelial cells. J. Natl. Cancer Inst. 2010, 102, 1322-1335.
    • (2010) J. Natl. Cancer Inst. , vol.102 , pp. 1322-1335
    • Lee, C.H.1    Huang, C.S.2    Chen, C.S.3    Tu, S.H.4
  • 27
    • 0037251810 scopus 로고    scopus 로고
    • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    • West, K. A., Brognard, J., Clark, A. S., Linnoila, I. R. et al., Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest. 2003, 111, 81-90.
    • (2003) J. Clin. Invest. , vol.111 , pp. 81-90
    • West, K.A.1    Brognard, J.2    Clark, A.S.3    Linnoila, I.R.4
  • 28
    • 78649333587 scopus 로고    scopus 로고
    • Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    • DOI: 10.1007/s10549-010-0916-x., in press
    • Iwasaki, M., Inoue, M., Sasazuki, S., Miura, T. et al., Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study. Breast Cancer Res. Treat. 2010, in press, DOI: 10.1007/s10549-010-0916-x.
    • (2010) Breast Cancer Res. Treat.
    • Iwasaki, M.1    Inoue, M.2    Sasazuki, S.3    Miura, T.4
  • 29
    • 0031980398 scopus 로고    scopus 로고
    • Influence of drinking green tea on breast cancer malignancy among Japanese patients
    • Nakachi, K., Suemasu, K., Suga, K., Takeo, T. et al., Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn. J. Cancer Res. 1998, 89, 254-261.
    • (1998) Jpn. J. Cancer Res. , vol.89 , pp. 254-261
    • Nakachi, K.1    Suemasu, K.2    Suga, K.3    Takeo, T.4
  • 30
    • 77956038678 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma
    • Luo, T., Wang, J., Yin, Y., Hua, H. et al., (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Res. 2010, 12, R8.
    • (2010) Breast Cancer Res. , vol.12
    • Luo, T.1    Wang, J.2    Yin, Y.3    Hua, H.4
  • 31
    • 0036282695 scopus 로고    scopus 로고
    • Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols
    • Weisburger, J. H., Chung, F. L., Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. Food Chem. Toxicol. 2002, 40, 1145-1154.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1145-1154
    • Weisburger, J.H.1    Chung, F.L.2
  • 32
    • 69249138207 scopus 로고    scopus 로고
    • Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha
    • Sun, X., Ritzenthaler, J. D., Zhong, X., Zheng, Y. et al., Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009, 69, 6445-6453.
    • (2009) Cancer Res. , vol.69 , pp. 6445-6453
    • Sun, X.1    Ritzenthaler, J.D.2    Zhong, X.3    Zheng, Y.4
  • 33
    • 34247892269 scopus 로고    scopus 로고
    • Epigallocatechin gallate dose-dependently induces apoptosis or necrosis in human MCF-7 cells
    • Hsuuw, Y. D., Chan, W. H., Epigallocatechin gallate dose-dependently induces apoptosis or necrosis in human MCF-7 cells. Ann. NY Acad. Sci. 2007, 1095, 428-440.
    • (2007) Ann. NY Acad. Sci. , vol.1095 , pp. 428-440
    • Hsuuw, Y.D.1    Chan, W.H.2
  • 34
    • 33644661615 scopus 로고    scopus 로고
    • Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols
    • Lin, J. K., Lin-Shiau, S. Y., Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol. Nutr. Food Res. 2006, 50, 211-217.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 211-217
    • Lin, J.K.1    Lin-Shiau, S.Y.2
  • 35
    • 0032807021 scopus 로고    scopus 로고
    • Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade
    • Lin, J. K., Liang, Y. C., Lin-Shiau, S. Y., Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem. Pharmacol. 1999, 58, 911-915.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 911-915
    • Lin, J.K.1    Liang, Y.C.2    Lin-Shiau, S.Y.3
  • 36
    • 25644447454 scopus 로고    scopus 로고
    • Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells
    • Lee, Y. R., Park, J., Yu, H. N., Kim, J. S. et al., Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells. Biochem. Biophys. Res. Commun. 2005, 336, 1221-1226.
    • (2005) Biochem. Biophys. Res. Commun. , vol.336 , pp. 1221-1226
    • Lee, Y.R.1    Park, J.2    Yu, H.N.3    Kim, J.S.4
  • 37
    • 33751552134 scopus 로고    scopus 로고
    • Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity
    • Likhite, V. S., Stossi, F., Kim, K., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. Mol. Endocrinol. 2006, 20, 3120-3132.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 3120-3132
    • Likhite, V.S.1    Stossi, F.2    Kim, K.3    Katzenellenbogen, B.S.4    Katzenellenbogen, J.A.5
  • 38
    • 42549131382 scopus 로고    scopus 로고
    • Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity
    • Thomas, R. S., Sarwar, N., Phoenix, F., Coombes, R. C., Ali, S., Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity. J. Mol. Endocrinol. 2008, 40, 173-184.
    • (2008) J. Mol. Endocrinol. , vol.40 , pp. 173-184
    • Thomas, R.S.1    Sarwar, N.2    Phoenix, F.3    Coombes, R.C.4    Ali, S.5
  • 39
    • 0037173738 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
    • Chen, D., Washbrook, E., Sarwar, N., Bates, G. J. et al., Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera. Oncogene 2002, 21, 4921-4931.
    • (2002) Oncogene , vol.21 , pp. 4921-4931
    • Chen, D.1    Washbrook, E.2    Sarwar, N.3    Bates, G.J.4
  • 40
    • 0037469744 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene
    • Pasapera Limon, A. M., Herrera-Munoz, J., Gutierrez-Sagal, R., Ulloa-Aguirre, A., The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene. Mol. Cell. Endocrinol. 2003, 200, 199-202.
    • (2003) Mol. Cell. Endocrinol. , vol.200 , pp. 199-202
    • Pasapera Limon, A.M.1    Herrera-Munoz, J.2    Gutierrez-Sagal, R.3    Ulloa-Aguirre, A.4
  • 41
    • 50249163362 scopus 로고    scopus 로고
    • Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer
    • Yamashita, H., Nishio, M., Toyama, T., Sugiura, H. et al., Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer. Endocr. Relat. Cancer 2008, 15, 755-763.
    • (2008) Endocr. Relat. Cancer , vol.15 , pp. 755-763
    • Yamashita, H.1    Nishio, M.2    Toyama, T.3    Sugiura, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.