Pharmacology of neuronal nicotinic acetylcholine receptors: Effects of acute and chronic nicotine

Nicotine and Tobacco Research

Volumn 1, Issue SUPPL. 2, 1999, Pages

  Kellar, Kenneth J ^a   Dávila García, Martha I ^a   Xiao, Yingxian ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE; NICOTINIC RECEPTOR;

ADOLESCENT; ANIMAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN; DRUG EFFECT; HUMAN; METABOLISM; SPINAL CORD; TOBACCO DEPENDENCE;

ADOLESCENT; ANIMAL; AUTONOMIC NERVOUS SYSTEM; BRAIN; HUMAN; NICOTINE; RECEPTORS, NICOTINIC; SPINAL CORD; SUPPORT, U.S. GOV'T, P.H.S.; TOBACCO USE DISORDER;

EID: 0033302327     PISSN: 14622203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ballivet M, Nef P, Couturier S, Rungger D, Bader CR, Bertrand D, Cooper E. 1988. Electrophysiology of chick neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes after cDNA injection. Neuron 1:847-852.
2. 3H]nicotine binding sites in human brain. Journal of Neurochemistry 50:1243-1247.
3. 3H]nicotine binding in human postmortem brain. Journal of Pharmacology and Experimental Therapeutics 282:7-13.
4. Dávila-García MI, Kellar KJ. 1998. Regulation of nicotinic receptors in superior cervical ganglia, retina and pineal: effects of chronic exposure to nicotine. Society for Neuroscience Abstracts 24:338.
5. Flores CM, Rogers SW, Pabreza LA, Wolfe BB, Kellar KJ. 1992. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Molecular Pharmacology 41:31-37.
6. Flores CM, Dávila-García MI, Ulrich YM, Kellar KJ. 1997. Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration. Journal of Neurochemistry 69:2216-2219.
7. Gopalakrishnan M, Monteggia LM, Anderson DJ, Molinari EJ, Piattoni-Kaplan M, Donnelly-Roberts D, Arneric SP. Sullivan, JP. 1996. Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine α4β2 receptor. Journal of Pharmacology and Experimental Therapeutics 276:289-297.
8. Gopalakrishnan M, Molinari EJ, Sullivan JP. 1997. Regulation of human α4β2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Molecular Pharmacology 52:524-534.
9. Hulihan-Giblin BA, Lumpkin MD, Kellar KJ. 1990a. Acute effects of nicotine on prolactin release in the rat: agonist and antagonist effects of a single injection of nicotine. Journal of Pharmacology and Experimental Therapeutics 252:15-20.
10. Hulihan-Giblin BA, Lumpkin MD, Kellar KJ. 1990b. Effects of chronic administration of nicotine on prolactin release in the rat: inactivation of prolactin release by repeated injections of nicotine. Journal of Pharmacology and Experimental Therapeutics 252:21-25.
11. Luetje CW, Patrick J. 1991. Both α- and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. Journal Neuroscience 11:837-845.
12. Marks MJ, Burch JB, Collins AC. 1983. Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. Journal of Pharmacology and Experimental Therapeutics 226:817-825.
13. Marshall DL, Redfern PH, Wonnacott S. 1997. Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats. Journal of Neurochemistry 68:1511-1519.
14. Papke RL, Heinemann SF. 1994. Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Molecular Pharmacology 45:142-149.
15. Parker MJ, Beck A, Luetje, CW. 1998. Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Molecular Pharmacology 54:1132-1139.
16. Perry DC, Dávila-García MI, Stockmeier CA, Kellar KJ. 1999. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. Journal of Pharmacology and Experimental Therapeutics 289:1545-1552.
17. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio L, Merlo-Pich E, Fuxe K, Changeux JP. 1998. β2-subunit containing acetylcholine receptors are involved in the reinforcing properties of nicotine. Nature 391:173-176.
18. Sargent PB. 1993. The diversity of neuronal nicotinic acetylcholine receptors. Annual Review of Neuroscience 16:403-443.
19. Schwartz RD, Kellar KJ. 1983. Nicotinic cholinergic receptor binding sites in brain: in vivo regulation. Science 220:214-216.
20. Sharp BM, Beyer HS. 1986. Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin. Journal of Pharmacology and Experimental Therapeutics 238:486-491.
21. Stauderman KA, Mahaffy LS, Akong M, Velicelebi G, Chavez-Noriega LE, Crona JH, Johnson EC, Elliott KJ, Gillespie A, Reid RT, Adams P, Harpold MM, Corey-Naeve, J. 1998. Characterization of human recombinant neuronal nicotinic acetycholine receptor subunit combinations α2β4, α3β4, and α4β4 stably expressed in HEK293 cells. Journal of Pharmacology and Experimental Therapeutics 284:777-789.
22. Vernallis AB, Conroy WG, Berg DK. 1993. Neurons assembly acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10:451-464.
23. Wang F, Nelson ME, Kuryatov A, Olale F, Cooper J, Keyser K, Lindstrom J. 1998. Chronic nicotine treatment up-regulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells. Journal of Biological Chemistry 273:28721-8732.
24. Whiting P, Schoepfer R, Lindstrom J, Priestly T. 1991. Structural and pharmacological characterization of the brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Molecular Pharmacology 40:463-472.
25. Wonnacott S. 1997. Presynaptic nicotinic ACh receptors. Trends in Neuroscience 20:92-98.
26. Xiao Y, Meyer EL, Houghtling RA, Thompson JM, Surin A, Wroblewski J, Kellar KJ. 1998. Rat α3β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function. Molecular Pharmacology 54:322-333.
27. Zoli M, Lena C, Picciotto MR, Changeux JP. 1998. Identification of four classes of brain nicotinic receptors using β2 mutant mice. Journal of Neuroscience 18:4461-4472.