Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo

Journal of Applied Toxicology

Volumn 17, Issue 1, 1997, Pages 75-79

  Springate, James E ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b CHILDREN S HOSPITAL OF BUFFALO   (United States)

Author keywords

Chloroacetaldehyde; Glutathione; Ifosfamide; Lipid peroxidation; Nephrotoxicity; Sodium 2 mercaptoethanesulfonate

Indexed keywords

CHLOROACETALDEHYDE; DRUG METABOLITE; GLUTATHIONE; IFOSFAMIDE; MALONALDEHYDE; MESNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FUNCTION; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETALDEHYDE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; GLYCOSURIA; IFOSFAMIDE; KIDNEY; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; MESNA; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY; SODIUM;

ANIMALIA; GLOMERULUS;

EID: 0031041912     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199701)17:1<75::AID-JAT397>3.0.CO;2-C     Document Type: Article

References (24)

1. R Skinner, I. Sharkey, A Pearson and A Craft, Ifosfamide, mesna and nephrotoxicity in children J. Clin. Oncol. 11, 173-190 (1993).
2. B. Raney, L. Ensign, J. Foreman, F. Khan, W. Newton, J. Ortega, A. Ragab, M. Wharam, E. Wiener and H. Maurer, Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor Am. J Pediatr. Hematol. Oncol. 16, 286-295 (1994).
3. T. Wagner, Ifosfamide clinical pharmacokmetics Clin. Pharmacokinet. 26, 439-456 (1994).
4. M. Zamlauski-Tucker, M Morris and J Sprmgate, Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney Toxicol. Appl. PharmaCol 129, 170-175 (1994).
5. C Sood and P O'Brien, Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes Biochem. Pharmacol. 46, 1621-1626 (1993)
6. M. Lind, A. McGown, J. Hadfield, N Thatcher, D Crowther and B Fox, The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo Biochem Pharmacol 38, 1835-1840 (1989)
7. T Meier, A. Allenbacher, E Mueller, G Multhoff, M Wiesnet and R Issels, Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna Anti-Cancer Drugs 5, 403-409 (1994).
8. J Fuhr, J Kacmarczyk and C Kruttgen, Eine einfache colorimetirische methode zur inulin bestimmung fur nieren-clearance-Untersuchungen bei stoffwechsel-gelsunden und diabetekern Pfflugers Arch 267, 128-137 (1955)
9. H Smith, N Finkelstein, L. Aliminosa, B. Crawford and M. Graber, The renal clearance of substituted hippuric acid derivatives and other aromatic acids in dog and man J. Clin. Invest 24, 388-404 (1945).
10. J Cho, R. Galaske, H Arbesman and J. Van Liew, Renal albumin reabsorption in normal and sodium maleatetreated rats Renal Physiol 8, 8-18 (1985)
11. H Ohkawa, N. Ohishi and K Yabi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95, 351-358 (1979)
12. 1 cells by metabolites of ifosfamide Renal Physiol Biochem 15, 289 301 (1992).
13. M Mohrmann. S Ansorge, U Schmich, B. Schonfeld and M Brandis, Toxicity of ifosfamide. cyclophosphamide and their metabolites in renal tubular cells in culture Pediatr Nephrol 8, 157-163 (1994)
14. L Dworkin and B Brenner, The renal circulations In The Kidney, ed. by B. Brenner and F. Rector, pp. 179-182 W. B. Saunders Co , Philadelphia, PA (1991).
15. M. Mohrmann, N. Kupper, B. Schonfeld and M Brandis, Ifosfamide and mesna: effects on the Na/H exchanger in renal epithelial cells in culture. Renal Physiol Biochem 18, 118-127 (1995)
16. C. Sood and P. O'Brien, Chloroacetaldehyde-induced hepatocyte cytotoxicity: mechanisms for cytoprotection. Biochem. Pharmacol 48, 1025-1032 (1994).
17. S. Somani, R. Ravi and L. Rybak, Diethyldithiocarbamate protection against ciplatin nephrotoxicity. antioxidant system. Drug Chem. Toxicol. 18, 151-170 (1995).
18. 1 cells mechanisms of injury Am J. Physiol. 265, F377-F384 (1993).
19. 1) cell injury. Am. J. Physiol. 268, F30-F38 (1995).
20. A Sheridan, S. Fitzpatrick, C. Wang, D. Wheeler and W Lieberthal, Lipid peroxidation contributes to hydrogen peroxide induced cytotoxicity in renal epithelial cells. Kidney Int. 49, 88-93 (1996).
21. K Ormstad, S. Orrenius, T Lastbom, N. Uehara, J Pohl, J. Stekar and N. Brock, Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat. Cancer Res. 43, 333-338 (1983)
22. K Ormstad and N Uehara, Renal transport and disposition of Na-2-mercaptoethane sulfonate disulfide (dimesna) in the rat. FEBS Lett. 150, 354-358 (1982).
23. N. Brock, P. Hilgard, J. Pohl and J. Stekar, Pharmacokinetics and mechanism of action of detoxifying low-molecular-weight thiols. J. Cancer Res. Clin. Oncol. 108, 87-97 (1984).
24. 1 cells. Pediatr. Nephrol. 8, 458-465 (1994).