NF-κB-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro

Genes and Development

Volumn 10, Issue 1, 1996, Pages 37-49

  Pazin, Michael J ^a   Sheridan, Philip L ^b   Cannon, Keith ^b   Cao, Zhaodan ^c   Keck, James G ^c   Kadonaga, James T ^a   Jones, Katherine A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c AMGEN INC   (United States)

Author keywords

chromatin structure; HIV 1 enhancer; NF B; transcription

Indexed keywords

COMPLEMENTARY DNA; OLIGODEOXYNUCLEOTIDE; RECOMBINANT PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; VIRUS DNA;

ARTICLE; CHROMATIN STRUCTURE; ENHANCER REGION; GENE EXPRESSION REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENETICS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029671333     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.1.37     Document Type: Article

References (62)

1. Archer, T.K., P. Lefevre, R.G. Wolford, and G.L. Hager 1992. Transcription factor loading on the MMTV promoter: A bimodal mechanism for promoter activation. Science 255: 1573-1576.
2. Baeuerle, P.A. and T Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12: 141-179.
3. Ballard, D.W., E.P. Dixon, N.J. Peffer, H. Bogerd, S. Doerre, B. Stein, and W.C. Greene. 1992. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. 89: 1875-1879.
4. Barton, M.C., N. Madani, and B.M. Emerson. 1993. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled β-globin genes. Genes & Dev. 7: 1796-1809
5. Beg, A.A., W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the ReIA component of NF-κB. Nature 376: 167-170.
6. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of I κ B-α proteolysis by site-specific, signal-induced phosphorylation. Science 267: 1485-1488.
7. Bulger, M. and J.T. Kadonaga. 1994. Biochemical reconstitution of chromatin with physiological nucleosome spacing. Methods Mol. Genet. 5: 241-262.
8. Crabtree, G. and N. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63: 1045-1083.
9. Croston, G.E., P.J. Laybourn, S.M. Paranjape, and J.T. Kadonaga. 1992. Mechanism of transcriptional antirepression by GAL4-VP16. Genes & Dev. 6: 2270-2281.
10. Di Donato, J.A., F. Mercurio, and M. Karin. 1995. Phosphorylation of I κ B α precedes but is not sufficient for its dissociation from NF-κ B. Mol. Cell. Biol 15: 1302-1311.
11. Duckett, C.S., N.D. Perkins, T.F. Kowalik, R.M. Schmid, E.S. Huang, A.S. Baldwin Jr., and G.J. Nabel. 1993. Dimerization of NF-κB2 with RelA (p65) regulates DNA binding, transcriptional activation, and inhibition by an I κ B-α (MAD-3). Mol. Cell Biol. 13: 1315-1322.
12. El Kharroubi, A. and E. Verdin. 1994. Protein-DNA interactions within the DNase I-hypersensitive sites located downstream of the HIV-1 promoter. J. Biol. Chem. 269: 19916-19924.
13. Elroy-Stein, O. and B. Moss. 1992. Gene expression using the vaccinia virus / T7 polymerase hybrid system. In Current protocols in molecular biology (ed. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl), pp. 16.19.1-16.19.12. Greene Publishing Associates/ Wiley Interscience, New York, NY.
14. Felsenfeld, G. 1992. Chromatin as an essential part of the transcriptional mechanism. Nature 355: 219-224.
15. Fujita, T., G.P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes &. Dev. 6: 775-787.
16. Ganchi, P.A., S.-C. Sun, W.C. Greene, and D. Ballard. 1993 A novel NF-κB complex containing p65 homodimers: Implications for transcriptional control at the level of subunit dimerization. Mol. Cell. Biol. 13: 7826-7835.
17. Gross, D.S. and W.T. Garrard. 1988. Nuclease hypersensitive sites in chromatin. Annu. Rev. Biochem. 57: 159-197.
18. Hirschhorn, J.N., A.L. Bortvin, S.L. Ricupero-Hovasse, and F. Winston. 1995 A new class of histone H2A mutations in Saccharomyces cerevisiae causes specific transcriptional defects in vivo. Mol. Cell. Biol. 15: 1999-2009.
19. Izban, M. and D. Luse. 1991. Transcription of nucleosomal templates by RNA polymerase II in vitro: Inhibition of elongation with enhancement of sequence-specific pausing. Genes & Dev. 5: 683-696.
20. Jeang, K.-T., B. Berkhout, and B. Dropulic. 1993. Effects of integration and replication on transcription of the HIV-1 long terminal repeat. J. Biol. Chem. 268: 24920-24949.
21. Jones, K.A. and B.M. Peterlin. 1994. Control of RNA initiation and elongation at the HIV-1 promoter. Annu. Rev. Biochem. 63: 717-743.
22. Kamakaka, R.T., M. Bulger, and J.T. Kadonaga. 1993. Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly. Genes & Dev. 7: 1779-1795.
23. Kerr, L., L. Ransone, P. Wamsley, M. Schmitt, T. Boyer, Q. Zhou, A Berk, and I. Verma. 1993. Association between proto-oncoprotein /Rel and TATA-binding proteins mediates transcriptional activation by NF-κB. Nature 338: 39-44.
24. Kim, J.Y.H., F. Gonzalez-Scarano, S.L. Zeichner, and J.C. Alwine. 1993. Replication of type I human immunodeficiency viruses containing linker substitution mutations in the -201 to -130 region of the long terminal repeat. J. Virol. 67: 1658-1662.
25. Kretzschmar, M., M. Meisteremst, C. Scheidereit, G. Li, and R.G. Roeder. 1992 Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes & Dev. 6: 761-774.
26. Laybourn, P.J. and J.T. Kadonaga. 1991. Role of nucleosomal cores and histone HI in regulation of transcription by RNA polymerase II. Science 254: 238-245.
27. _. 1992. Threshold phenomena and long-distance activation of transcription by RNA polymerase II. Science 257: 1682-1685.
28. Li, Y., G. Mak, and B.R. Franza Jr. 1994. In vitro study of functional involvement of Sp1, NF-κB/Rel, and AP1 in phorbol 12-myristate 13-acetate-mediated HIV-1 long terminal repeat activation. J. Biol. Chem. 269: 30616-30619.
29. Lin, R., D. Gewert, and J. Hiscott. 1995. Differential transcriptional activation in vitro by NF-kappa B/Rel proteins. J. Biol. Chem. 270: 3123-3131.
30. Liou, H.-C. and D. Baltimore. 1993. Regulation of the NF-κB/rel transcription factor and the IκB inhibitor system. Curr. Opin. Cell Biol. 5: 477-487.
31. Mackett, M., G.L. Smitch, and B. Moss. 1984. General method for production and selection of infectious vaccinia virus recombinants for expressing foreign genes. J. Virol. 49: 857-864.
32. Miyamoto, S. and I.M. Verma. 1995. Rel/NF-κB/IκB Story. Adv. Cancer Res. 66: 255-292.
33. Moore, P.A., S.M. Ruben, and C.A Rosen. 1993. Conservation of transcriptional activation functions of the NF-κB p50 and p65 subunits in mammalian cells and Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 1666-1674.
34. Morse, R.H. 1993. Nucleosome disruption by transcription factor binding in yeast. Science 262: 1563-1566.
35. Moss, B., O. Elroy-Stein, T. Mizukami, W.A. Alexander, and T.R. Fuerst. 1990. New mammalian expression vectors. Nature 348: 91-92.
36. Mymryk, J.S. and T.K. Archer. 1995. Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo. Genes &. Dev. 9: 1366-1376.
37. Nedospasov, S.A. and G.P. Georgiev. 1980. Non-random cleavage of SV40 DNA in the compact minichromosome and free in solution by micrococcal nuclease. Biochem. Biophys. Res. Commun. 92: 532-539.
38. Noll, M. and R.D. Kornberg. 1977. Action of micrococcal nuclease on chromatin and the location of histone H1. J. Mol. Biol 109: 393-404.
39. Paranjape, S.M., R.T. Kamakaka, and J.T. Kadonaga. 1994. Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu. Rev. Biochem. 63: 265-297.
40. Pazin, M.J., R.T. Kamakaka, and J.T. Kadonaga. 1994. ATP-dependent nucleosome reconfiguration and transcriptional activation from preassembled chromatin templates. Science 266: 2007-2011.
41. Perkins, N.D., R.M. Schmid, C.S. Duckett, K. Leung, N.R. Rice, and G.J. Nabel. 1992. Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. 89: 1529-1533.
42. Perkins, N.D., N.L. Edwards, C.S. Duckett, A.B. Agranoff, R.M. Schmid, and G.J. Nabel. 1993. A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12: 3551-3558.
43. Perkins, N.D., A.B. Agranoff, E. Pascal, and G.J. Nabel. 1994. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol. Cell. Biol. 14: 6570-6583.
44. Qian, J., V. Bours, J. Manischewitz, R. Blackburn, U. Siebenlist, and H. Golding. 1994. Chemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-κB DNA binding proteins. J. Immunol. 152: 4183-4191.
45. Richard-Foy, H. and G. Hager. 1987. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO J. 6: 2321-2328.
46. Ron, D. and H. Dressler. 1992. pGSTag - A versatile bacterial expression plasmid for enzymatic labelling of recombinant proteins. BioTechnology 13: 866-869.
47. Ross, E.K., A.J Buckler-White, A.B. Rabson, G Englund, and M.A. Martin. 1991. Contribution of NF-κB and Sp1 binding motifs to the replicative capacity of the human immunodeficiency virus type 1: Distinct patterns of viral growth are determined by T-cell types. J. Virol 65: 4350-4358.
48. Schmid, R., S. Liptay, J. Betts, and G. Nabel. 1994. Structural and functional analysis of NF-κB. J. Biol. Chem. 269: 32162-32167.
49. Schmitz, M. and P. Baeuerle. 1991 The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10: 3805-3817.
50. Schmitz, M., M. dos Santos Silva, H. Altmann, M. Czisch, T. Holak, and P. Baeuerle. 1994. Structure and functional analysis of the NF-κB p65 C terminus. J. Biol Chem. 269: 25613-25620.
51. Schmitz, M., G. Stelzer, H. Altmann, M. Meisterernst, and P. Baeuerle. 1995. Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding proteins, transcription factor IIB, and coactivators. J. Biol. Chem. 270: 7219-7226.
52. Sha, W.C., H.-C Liou, E.I. Toumanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80: 321-330.
53. Sheridan, P.L., C.T. Sheline, K. Cannon, M.L. Voz, M.J. Pazin, J.T. Kadonaga, and K.A. Jones. 1995. Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA m vitro. Genes & Dev. 9: 2090-2104.
54. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation, and function of NF-κB. Annu. Rev. Cell Biol. 10: 405-455.
55. Sif, S. and T.D. Gilmore. 1994. Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1. J. Virol. 68: 7131-7138.
56. Tsukiyama, T., P.B. Becker, and C. Wu. 1994. ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367: 525-532.
57. Verdin, E. 1991. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1. J. Virol. 65: 6790-6799.
58. Verdin, E., P. Paras Jr., and C. Van Lint. 1993. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during trancriptional activation. EMBO J. 12: 3249-3259.
59. Waterman, M.L and K.A. Jones. 1990. Purification of TCF-1α, a T-cell-specific transcription factor that activates the T-cell receptor Cα gene enhancer in a context-dependent manner. New Biol 2: 621-636.
60. Workman, J.L., I.C.A. Taylor, and R.E. Kingston. 1991. Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes. Cell 64: 533-544
61. Wu, C. 1980. The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286: 854-860.
62. Xu, X., C. Prorock, H. Ishikawa, E. Maldonado, Y. Ito, and C. Gelinas. 1993. Functional interaction of the v- Rel and c-Rel oncoproteins and association with transcription factor IIB. Mol. Cell. Biol. 13: 6733-6741.