Left-right axis determination

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Volumn 1, Issue 2, 2009, Pages 210-219

  Ibañes, Marta ^a   Belmonte, Juan Carlos Izpisúa ^b,c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c CENTER OF REGENERATIVE MEDICINE IN BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA; VERTEBRATA;

ANIMAL; BIOLOGICAL MODEL; EUKARYOTIC FLAGELLUM; GENE REGULATORY NETWORK; GENETIC EPIGENESIS; GENETICS; HUMAN; HYDRODYNAMICS; MORPHOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SYSTEMS BIOLOGY; VERTEBRATE;

ANIMALS; BODY PATTERNING; CILIA; EPIGENESIS, GENETIC; GENE REGULATORY NETWORKS; HUMANS; HYDRODYNAMICS; MODELS, BIOLOGICAL; SYSTEMS BIOLOGY; VERTEBRATES;

EID: 79952116696     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.31     Document Type: Article

References (76)

1. Bisgrove BW, Morelli SH, Yost HJ. Genetics of human laterality disorders: insights from vertebrate model systems. Annu Rev Genomics Hum Genet 2003, 4:1-32.
2. Bisgrove BW, Yost HJ. Classification of left-right patterning defects in zebrafish, mice, and humans. Am J Med Genet 2001, 101:315-323.
3. Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 1995, 82:803-814.
4. Hamada H, Meno C, Watanabe D, Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat Rev Genet 2002, 3:103-113.
5. Capdevila J, Vogan KJ, Tabin CJ, Izpisua Belmonte JC. Mechanisms of left-right determination in vertebrates. Cell 2000, 101:9-21.
6. Hirokawa N, Tanaka Y, Okada Y, Takeda S. Nodal flow and the generation of left-right asymmetry. Cell 2006, 125:33-45.
7. Levin M. Left-right asymmetry in embryonic development: a comprehensive review. Mech Dev 2005, 122:3-25.
8. Lopez-Gracia ML, Ros MA: Left-right asymmetry in vertebrate development. Adv Anat Embryol Cell Biol 2007, 188:1-121, back cover.
9. Mercola M, Levin M. Left-right asymmetry determination in vertebrates. Annu Rev Cell Dev Biol 2001, 17:779-805.
10. Raya A, Belmonte JC. Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nat Rev Genet 2006, 7:283-293.
11. Tabin C. Do we know anything about how left-right asymmetry is first established in the vertebrate embryo? J Mol Histol 2005, 36:317-323.
12. Yost HJ. Establishment of left-right asymmetry. Int Rev Cytol 2001, 203:357-381.
13. Burdine RD, Schier AF. Conserved and divergent mechanisms in left-right axis formation. Genes Dev 2000, 14:763-776.
14. Palmer AR. Symmetry breaking and the evolution of development. Science 2004, 306:828-833.
15. Schlueter J, Brand T. Left-right axis development: examples of similar and divergent strategies to generate asymmetric morphogenesis in chick and mouse embryos. Cytogenet Genome Res 2007, 117:256-267.
16. Speder P, Petzoldt A, Suzanne M, Noselli S. Strategies to establish left/right asymmetry in vertebrates and invertebrates. Curr Opin Genet Dev 2007, 17:351-358.
17. Rasskin-Gutman D, Ibañes M, Izpisúa-Belmonte JC. Modeling developmental asymmetries. In: Laubichler MD, Müller GB, eds. Modeling Biology. Structures, Behaviors, Evolution: Cambridge, MA: MIT Press; 2007, 143-164.
18. Graham JH, FReeman DC, Emlen JM. Antisimmetry, directional asymmetry, and dynamic morphogenesis. Genetica 1993, 89:121-137.
19. Brown NA, Wolpert L. The development of handedness in left/right asymmetry. Development 1990, 109:1-9.
20. Vogan KJ, Tabin CJ. A new spin on handed asymmetry. Nature 1999, 397(:295,):297-298.
21. Afzelius BA. A human syndrome caused by immotile cilia. Science 1976, 193:317-319.
22. Supp DM, Witte DP, Potter SS, BruecknerM.Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature 1997, 389:963-966.
23. Shiratori H, Hamada H. The left-right axis in the mouse: from origin to morphology. Development 2006, 133:2095-2104.
24. Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, et al. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 1998, 95:829-837.
25. Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A 1999, 96:5043-5048.
26. Okada Y, Nonaka S, Tanaka Y, Saijoh Y, Hamada H, et al. Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol Cell 1999, 4:459-468.
27. Takeda S, Yonekawa Y, Tanaka Y, Okada Y, Nonaka S, et al. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol 1999, 145:825-836.
28. Nonaka S, Shiratori H, Saijoh Y, Hamada H. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 2002, 418:96-99.
29. Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, et al. The left-right determinant inversin is a component of node monocilia and other 9+0 cilia. Development 2003, 130:1725-1734.
30. Cartwright JH, Piro O, Tuval I. Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates. Proc Natl Acad Sci U S A 2004, 101:7234-7239.
31. Brokaw CJ. Computer Simulation of flagellar movement: IX. Oscillation and symmetry breaking in a model for short flagella and nodal cilia. Cell Motil Cytoskeleton 2005, 60:35-47.
32. Buceta J, Ibañes M, Rasskin-Gutman D, Okada Y, Hirokawa N, et al. Nodal cilia dynamics and the specification of the left/right axis in early vertebrate embryo development. Biophys J 2005, 89:2199-2209.
33. Nonaka S, Yoshiba S, Watanabe D, Ikeuchi S, Goto T, et al. De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS Biol 2005, 3:e268.
34. Okada Y, Takeda S, Tanaka Y, Belmonte JC, Hirokawa N. Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. Cell 2005, 121:633-644.
35. Cartwright JH, Piro N, Piro O, Tuval I. Embryonic nodal flow and the dynamics of nodal vesicular parcels. J R Soc Interface 2007, 4:49-55.
36. Smith DJ, Gaffney EA, Blake JR. Discrete cilia modelling with singularity distributions: application to the embryonic node and the airway surface liquid. Bull Math Biol 2007, 69:1477-1510.
37. Hilfinger A, Jülicher F: The chirality of ciliary beats. Phys Biol 2008, 5:016003(016012pp).
38. Smith DJ, Blake JR, Gaffney EA. Fluid mechanics of nodal flow due to embryonic primary cilia. J R Soc Interface 2008, 5:567-573.
39. Blake JR. Hydrodynamic calculation on the movements of cilia and flagella. I. Paramecium. J Theor Biol 1974, 45:183-203.
40. Gray J, Hancok GJ. The propulsion of sea-urchin spermatozoa. J Exp Biol 1955, 32:802-814.
41. Sleigh MA. Cilia and Flagella. New York: Academic Press; 1974.
42. Essner JJ, Amack JD, Nyholm MK, Harris EB, Yost HJ. Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 2005, 132:1247-1260.
43. Kawakami Y, Raya A, Raya RM, Rodriguez-Esteban C, Izpisúa Belmonte JC. Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 2005, 435:165-171.
44. Kramer-Zucker AG, Olale F, Haycraft CJ, Yoder BK, Schier AF, et al. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 2005, 132:1907-1921.
45. Schweickert A, Weber T, Beyer T, Vick P, Bogusch S, et al. Cilia-Driven leftward flow determines laterality in Xenopus. Curr Biol 2007, 17:60-66.
46. Danilchik MV, Brown EE, Riegert K. Intrinsic chiral properties of the Xenopus egg cortex: an early indicator of left-right asymmetry? Development 2006, 133:4517-4526.
47. +-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development 2006, 133:1657-1671.
48. Aw S, Adams DS, Qiu D, Levin M. H, K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry. Mech Dev 2008, 125:353-372.
49. +-ATPase and cell membrane potentials comprise a very early step in left-right patterning. Cell 2002, 111:77-89.
50. Fischer A, Viebahn C, Blum M. FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr Biol 2002, 12:1807-1816.
51. Essner JJ, Vogan KJ, Wagner MK, Tabin CJ, Yost HJ. et al. Conserved function for embryonic nodal cilia. Nature 2002, 418:37-38.
52. Cooke J. The evolutionary origins and significance of vertebrate left-right organisation. Bioessays 2004, 26:413-421.
53. Levin M, Palmer AR. Left-right patterning from the inside out: widespread evidence for intracellular control. Bioessays 2007, 29:271-287.
54. McGrath J, Brueckner M. Cilia are at the heart of vertebrate left-right asymmetry. Curr Opin Genet Dev 2003, 13:385-392.
55. Mercola M. Left-right asymmetry: nodal points. J Cell Sci 2003, 116:3251-3257.
56. Wood WB. The left-right polarity puzzle: determining embryonic handedness. PLoS Biol 2005, 3:e292.
57. Levin M. Motor protein control of ion flux is an early step in embryonic left-right asymmetry. Bioessays 2003, 25:1002-1010.
58. Collignon J, Varlet I, Robertson EJ. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 1996, 381:155-158.
59. Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, et al. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 1996, 381:158-161.
60. Brennan J, Norris DP, Robertson EJ. Nodal activity in the node governs left-right asymmetry. Genes Dev 2002, 16:2339-2344.
61. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, et al. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev 2003, 17:1207-1212.
62. Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, et al. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev 2003, 17:1213-1218.
63. Raya A, Kawakami Y, Rodriguez-Esteban C, IbañesM, Rasskin-Gutman D, et al. Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. Nature 2004, 427:121-128.
64. Saijoh Y, Oki S, Ohishi S, Hamada H. Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol 2003, 256:160-172.
65. Raya A, Belmonte JC. Sequential transfer of left-right information during vertebrate embryo development. Curr Opin Genet Dev 2004, 14:575-581.
66. Raya A, Izpisua Belmonte JC. Unveiling the establishment of left-right asymmetry in the chick embryo. Mech Dev 2004, 121:1043-1054.
67. Aizawa H, Goto M, Sato T, Okamoto H. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Dev Cell 2007, 12:87-98.
68. Meinhardt H. Organizer and axes formation as a selforganizing process. Int J Dev Biol 2001, 45:177-188.
69. Nakamura T, Mine N, Nakaguchi E, Mochizuki A, Yamamoto M, et al. Generation of robust left-right asymmetry in the mouse embryo requires a selfenhancement and lateral-inhibition system. Dev Cell 2006, 11:495-504.
70. Meinhardt H. Models of biological pattern formation: from elementary steps to the organization of embryonic axes. Curr Top Dev Biol 2008, 81:1-63.
71. Tanaka Y, Okada Y, Hirokawa N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 2005, 435:172-177.
72. Tabin CJ, Vogan KJ. A two-cilia model for vertebrate left-right axis specification. Genes Dev 2003, 17:1-6.
73. McGrath J, Somlo S, Makova S, Tian X, Brueckner M. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 2003, 114:61-73.
74. Kurpios NA, Ibañes M, Davis NM, Lui W, Katz T, et al. Directional gut looping is mediated by changes in the extracellular matrix and in cell:cell adhesion. Proc Natl Acad Sci U S A 2008, 105:8499-8506.
75. Rasskin-Gutman D, Izpisua-Belmonte JC. Theoretical morphology of developmental asymmetries. Bioessays 2004, 26:405-412.
76. Yashiro K, Shiratori H, Hamada H. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature 2007, 450:285-288.